ID   A0A2K5Z6K4_MANLE        Unreviewed;      1238 AA.
AC   A0A2K5Z6K4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Rho guanine nucleotide exchange factor 10 like {ECO:0000313|Ensembl:ENSMLEP00000023454.1};
GN   Name=ARHGEF10L {ECO:0000313|Ensembl:ENSMLEP00000023454.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000023454.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000023454.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5Z6K4; -.
DR   Ensembl; ENSMLET00000046970.1; ENSMLEP00000023454.1; ENSMLEG00000035543.1.
DR   GeneTree; ENSGT00940000153798; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          275..462
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1094..1122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1145..1167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          442..475
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        29..46
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..194
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1238 AA;  135596 MW;  480807C64C07E78B CRC64;
     MASSNPPPQP AIGDQLVPGA PGPSSEAEDD PGEAFEFDDS DDEEDTSAVL GVPSLAPKRD
     TDPPLIHFDS IPVTDPDPAA APPSTEVPAW VSNGDAADAA FSGARHSSWK RKSSRRIDRF
     TFPALEEDVI YDDVPCESPD AHQPGAERNL LYEDAHRAGA PRQAEDLGWS SSEFESYSED
     SGEEAKPEVE PTKHRVSFQP KMTQLMKAAK SGTKDGLEKT RMAVMRKVSF LHRKDVLGDS
     EEEDMGLLEV SVSDIKPPAP ELGPMPEGLS PQQVVRRHIL GSIVQSEGSY VESLKRILQD
     YRNPLMEMEP KALSARKCQV VFFRVKEILH CHSMFQIALS SRVAEWDSTE KIGDLFVASF
     SKSMVLDVYS DYVNNFTSAM SIIKKACLTK PAFLEFLKRR QVCSPDRVTL YGLMVKPIQR
     FPQFILLLQD MLKNTPRGHP DRLSLQLALT ELETLAEKLN EQKRLADQVA EIQQLTKSVS
     DRSSLNKLLT SGQRQLLLCE TLTETVYGDR GQLIKSKERR VFLLNDMLVC ANINFKPANH
     RGQLEISSLV PLGPKYVVKW NTALPQVQVV EVGQDGGTYD KDNVLIQHAG AKKASTSGQA
     QNKVYLGPPR LFQELQDLQK DLAVVEQITL LISTLHGTYQ NLNMTVAQDW CLALQRLMRV
     KEEEIHSANK CRLRLLLPGK PDKSGRPISF MVVFITPNPL SKISWVNRLH LAKLGLREEN
     QPGWLCPDED KKSKAPFWCP ILACCIPAFS SRALSLQLGA LVHSPVNCPL LGFSAVSTSL
     PQGYLWVGGG QEGAGGQVEI FSLNRPSPRT VKSFPLAAPV LCMEYIPELE EEAESRDESR
     TAADPSATVH PTICLGLQDG SILLYGSVDT GTQCLATCRS PGLQPVLCLR HSPFHLLAGL
     QDGTLAAYPR TSGGVLWDLE SPPVCLTVGP GPVRTLLSLE DAVWASCGPR VSVLEATTLQ
     PQQSFEAHQD EAVSVTHMVK AGSGVWMAFS SGTSIRLFHT ETLEHLQEIN IATRTTFLLP
     GQKHLCVTSL LICQGLLWVG TDQGVIVLLP VPRLEGIPKI TGKGMVSLNG HCGPVAFLAV
     ATSILAPDIL RSDQEEAEGP RAEEDKPDGQ AHEPVPDSHV GRELTRKKGI LLQYRLRSTA
     HLPGPLLSMR EPAPADGAAL EHSEEDGSIY EMADDPDVWV RSRPCARDAH RKEICSVAII
     SGGQGYRNFG SPLGSSGRPA PCGETDSTLL IWQVPLML
//