ID A0A2K5Z770_MANLE Unreviewed; 476 AA.
AC A0A2K5Z770;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Caspase 10 {ECO:0000313|Ensembl:ENSMLEP00000023580.1};
GN Name=CASP10 {ECO:0000313|Ensembl:ENSMLEP00000023580.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000023580.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000023580.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR RefSeq; XP_011829898.1; XM_011974508.1.
DR AlphaFoldDB; A0A2K5Z770; -.
DR Ensembl; ENSMLET00000047096.1; ENSMLEP00000023580.1; ENSMLEG00000035963.1.
DR GeneID; 105535423; -.
DR CTD; 843; -.
DR GeneTree; ENSGT00940000160994; -.
DR OMA; CRDCISH; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08814; DED_Caspase_10_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR035701; CASP10_DED2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF5; CASPASE 10; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 15..93
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 110..183
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 236..359
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 384..467
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 476 AA; 53906 MW; 2BFF676BD2A92EFD CRC64;
MKSQGSSSDK NCKVSFRKKL LIIDSDLGVE DVERLKFLCI GLVPNKKLEK SSSASDVFEH
LLAEDLLSEG DSFFLAELLY IIGQKKLLQY LNYTEEKVEQ LLPIQGKVSL FRNLLYELSQ
GIDSEDLKNM IFLLNDSLPK TEMTSLSFLA LLEKQDKIDE DNLTCLEDLC EMVVPKFLRN
IEKYKREKAA QIVTPPVDKE AESLYQGEEE LVSQTDIKTF LEALPWAPTY RMNRNHRGLC
VIVNNHRFIS LRDRRGTHKD AEILTGVFQW LGFTVHIYND VTKGEMEEVL QKEKCNPAHA
DGDCFVFCIL THGEDGAVYS SDEALIPIRE IMSHFTALQC PGLAEKPKLF FIQACQGEKI
QLSKSIEADA LNPEQAPTSL QDSIPVEADF LLGLATVPGY VSFRHVEEGS WYIQSLCNHL
KVLVPREEDI LSILTAVNDD VSRRVDKEGT KKQMPQPAFT LRKKLVFPVP LDALSL
//
