ID A0A2K5ZBS6_MANLE Unreviewed; 3675 AA.
AC A0A2K5ZBS6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=BRCA2 DNA repair associated {ECO:0000313|Ensembl:ENSMLEP00000025266.1};
GN Name=BRCA2 {ECO:0000313|Ensembl:ENSMLEP00000025266.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000025266.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000025266.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9568.ENSMLEP00000025266; -.
DR Ensembl; ENSMLET00000048796.1; ENSMLEP00000025266.1; ENSMLEG00000036824.1.
DR GeneTree; ENSGT00390000003602; -.
DR OMA; CWYTKLG; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0033593; C:BRCA2-MAGE-D1 complex; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1990391; C:DNA repair complex; IEA:Ensembl.
DR GO; GO:0000800; C:lateral element; IEA:Ensembl.
DR GO; GO:0000152; C:nuclear ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:Ensembl.
DR GO; GO:0010484; F:histone H3 acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0010485; F:histone H4 acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
DR GO; GO:0090398; P:cellular senescence; IEA:Ensembl.
DR GO; GO:0051298; P:centrosome duplication; IEA:Ensembl.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0070200; P:establishment of protein localization to telomere; IEA:Ensembl.
DR GO; GO:0008585; P:female gonad development; IEA:Ensembl.
DR GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
DR GO; GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR GO; GO:0007141; P:male meiosis I; IEA:Ensembl.
DR GO; GO:1990426; P:mitotic recombination-dependent replication fork processing; IEA:Ensembl.
DR GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:Ensembl.
DR GO; GO:0001556; P:oocyte maturation; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR GO; GO:0010225; P:response to UV-C; IEA:Ensembl.
DR GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR CDD; cd04495; BRCA2DBD_OB3; 1.
DR Gene3D; 6.10.70.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR Pfam; PF00634; BRCA2; 8.
DR Pfam; PF21318; BRCA2DBD_OB2; 1.
DR Pfam; PF09121; Tower; 1.
DR PIRSF; PIRSF002397; BRCA2; 2.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 10.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 1007..1041
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1216..1250
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1424..1458
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1520..1554
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1667..1701
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1840..1874
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 1974..2008
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 2055..2089
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 2228..2262
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT REPEAT 2309..2343
FT /note="BRCA2"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00032"
FT DOMAIN 3089..3130
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 40..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1726..1749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2686..2706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3648..3675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3675 AA; 412687 MW; FF19EA84D246DBC4 CRC64;
MSIGSKERPT FFEIFKTRCN KADLGPISLN WFEELSSEAA PYNSEPAEDS EHKNNSYEPN
LFKTPQRKPS YNQLASTPII FKERGLTLPP YQSPVKELDT FRLDLGRNVP SSRHKSLRTV
KAEMHQADDV TCPLLNSCLS ESPVVLQCTH VTPQRNKSVV CGSLFHTPKF VKGRQTPKHI
SESLGAEVDP DMSWSSSLAT PPTLSSTVLI VRNEEASETL FPHDTTANVK SYFSNHDKSL
KKNDRCIPSV TDSENTNQRE ATSHRFGRTL GNSFKVNSCK DHIGKSMPNV LEDEVYETVV
DTSEEDSFSL CFSKCRTGNL QKVRTSKTRK KIFREANADE CEKSKNQVKE KYSFVSEMES
SDTDPLDSNV ANQKPFESGS DKISKEVVPS LACEWSQLTL SGLDGTQMEK IPLLHISSCD
QNNSEKDLLN TENERKKDFL TSENSLPHIS SLPKSEKPLN EETVVNKRDE EQHLESHRDY
ILAVKQAVSE TSPMASSFQG IKKSIFRIRE SPKEIFNASF SGHVTDPNFK KETKASESGL
EIHTVCSRKD DSLCPNSIDN GSWPAATTQT SVASKNAGLI STLKKKTNKF IYAIHDETSY
QGKKMPKDQK SELMNCSAQF EANAFEAPLT FANADSGLFH SSVKRSCSQN YSEEPTLSLT
SSFGTILRKC SRNETCSSNN TIISQDLDYK EAKCNKKELQ LFITPEADSL SFLQEGQYEN
DPKSRKVSDI KEEVLAAAHH PVQHSKAEYS DTDFQSQESP LYDHENASTL ILTPTSKDVL
SNLVMISRGK ESYKMSDELK GNNYESDFEL TKNIPMEKNQ DVCALSENSK HVELLPPEKY
IRVASPSRKV QFNQNTNLRV IQKDQEEPTL IPKITVNPDS EELFSDNENN FVFQVVNERN
NFALGNTKEL HETDLTCVNE PIFKNSTMVL YADIGDKQAT QVSIKKDLDS SNIVYDLAEE
NKNSVKQHLK MTLGQDLQPD ILNIDKIADK NNDCMDKWAG PLDPISNHSF GGSFRTASNK
EIKVSEHNIK KSKMFFKDIE EQYPTSLACV EIVNTLALDN QKKLSKPQSI NTVSAQIQSS
VVVSDCKNSH ITPQMSFSKQ DFNSNHNLTP SQKAEITELS TILEESGSQF EFTQFRKPSY
ILQKNTFEVP ENQVTILNTT SAENRDAGLV IMNAPSIGQV DSSKQFEGTV GIKQKFAGLL
KNDCNKSASG YLTDENEVEF RGFYSAHGVK LNVSTEALQK AVKLFSDIEN ISEETSAEVD
PISLSSSKFH DSVVSMFKIE NHNDKTVSGK NKCQLMLQNN IEMTTGTFVE EITENYKINT
ENEDNKYTAA SRNSRNLEFV GSDSSKNDTV CIHKDEKDLP FTDQHNICLK LSGQFMKEGN
TQIKEGLSHL TFLEVVKAQE TCHGNTSNKE QLTATKTEQN IKDFETFDIS FQTASGKNIS
VTKESFNKIV NFFDPKPEEL HNFSLNSKLH SDIRKNKMDI LSHEETDTVK NKILKESVPV
GTGNQLVTFQ ERPQGDEKIK EPTLLGFHTA SGKKVKITKE SLDKVKNLFD EKEQGASEIT
SFSHQWAKTL KYREACKDLE LACETVEITT APKCKEMQNS LNNDKNLVSI ETVVPPKLLS
DHLCRQTENL KTSKSIFLKV KVHENVEKET AKSPATCYTN QSPYSVIENS ALAFYTSCSR
KRSVSQTSLL EAKQWLREGI FDDQPERINT ADYVGNSLYE NNSKNTIAES DKNHPSKKQD
TTLNNSSMSN SYSYLSDEVY SDSGYLSKNK LDSGIEPVLK KVEDQKNTSF SKVISSVKDA
NTYPQTVNEG ICVEELVTSS SPCKNKNAAI KVSISNCNNF EVGPPAFSTA SGKIICVSHE
TIKKVKEIFT DSFGKVIKEN NENKSNICQT KIVAGRYEAL DDSEDIFHNS LDSDECSMHS
HKVFADIQSE EILQHNQNMS GLEQVSKVSP CDVSLETSDI CKCSIGKFPK SVPSTNICGI
FSTASGKSVQ VSDASLQKAR QVFSEIKDST KQVCSKVLFK SNEHSDQLTR EENTTIHTPK
HLISSQKDFS YNVVNSSVFS GFSTASGKQV SISESSLHKV KGMLEEFDII RTEHSLHYSP
TSRQNVSKIL PCVDKRTPEH CVNSEMEKAC SKEFNLSNNF NVEGGSSENN HSIKVSPSLS
QFKQDKQQLC SMHSHKVFAD IQSEEILQHN QNMSGLEQVS KVSPCDVSLE TSDICKCSIG
KFPKSVPSTN ICGIFSTASG KSVQVSDASL QKARQVFSEI KDSTKQVCSK VLFKSNEHSD
QLTREENTTI HTPKHLISSQ KDFSYNVVNS SVFSGFSTAS GKQVSISESS LHKVKGMLEE
FDIIRTEHSL HYSPTSRQNV SKILPCVDKR TPEHCVNSEM EKACSKEFNL SNNFNVEGGS
SENNHSIKVS PSLSQFKQDK QQLVLGTKVS LVENIHVLGK EQASPENVKM EIGKTEAFSD
VPVKTNIEVC STYSKDSENY FETEAVEIAK AFMEDGELTD SELPSHATHS LFTRPQNEEM
VLSNSRIGKR RGEALISAGE PPIKRNLLNE FDRIIENQEK SLKPSKSTPD GTIKDRRLFM
HHVSLEPITC VPFCTTKERQ EIQNPNFTAP GQEFLSKSHL YEHLTLEKSS SNLAVSGHPF
YQVSATRNEK MRHLITTGKP TKVFIPPFKT KSHFHRDEQC VRNINLEENK QKQNIDGHGS
GDSKNKINDN EIHHFNKNNS NQAATVIFTK CEEEPLDLIT SLQNARDIQD MRIKKKQRQR
IFPQPGSLYL AKTSTLPRIS LKAAVGGQVP SACSHKQLYM YGVSKHCIKI NSKNAESFQF
YTQDYFGKES LWAGKGIQLA DGGWLIPSND GKAGKEEFYR ALCDTPGVDP KLISRIWVYN
HYRWIIWKLA AMECAFPKEF ANRCLSPERV LLQLKYRYDM EIDRSRRSAI KKIMERDDTA
AKTLVLCVSD IISLSANISE TSSNKTSSAD TQKVAIIELT DGWYAVKAQL DPPLLAVLKN
GRVTVGQKII LHGAELVGSP DACTPLEAPA SLMLKISANS TRPARWYTKL GFFPDPRPFP
LPLSSLFSDG GNVGCVDVII QRAYPIQWME KTSSGLYIFR NEREEEKEAA KYVEAQQKRL
EALFTKIQEE FEEHEENTTK PYLPSRALTR QQVRALQDGA ELYEAVKNAA DPAYLEGYFS
EEQLRALNNH RQMLNDKKQA QIQLEIRKAM ESAEQKEQGL SRDVTTVWKL RIVSYSKKEK
DSVILSIWRP SSDLYSLLTE GKRYRIYHLA TSKSKSKSER ANIQLAATKK TQYQQLPVSD
EILFQVYQPR EPLHFSKFLD PDFQPSFSEV DLIGFVVSVV KKTGLAPFIY LSDECYNLLA
IKFWIDLNED IIKPHMLIAA SNLQWRPESK SGLPTLFAGD FSVFSTSPKE GHFQETFNKM
KNTVENIDIL CNEAENKLMH ILHANDPKWS TPIKDWTSES YTAQIIPGTG NKLLISSPNC
ELYYQSPLSL CMAKRKSVST PVSAQITSKS CEGEKEIDDQ KSCKRRRALD FLSRLPLPPP
VSPICTFVSP AAQKAFQPPR SCGTKYQTPI KKKELNSPQM TPFKKFNEIS LSESNSIADE
ELALINTQAL LSGSTGEKQF ISVSESTRTT PTSSEDYLRR KRRCATSLIK EQERSRSGKE
ECENNRQDTI TAKKY
//
