ID A0A2K5ZDH8_MANLE Unreviewed; 1587 AA.
AC A0A2K5ZDH8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSMLEP00000025884.1};
GN Name=ADGRB2 {ECO:0000313|Ensembl:ENSMLEP00000025884.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000025884.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000025884.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 9568.ENSMLEP00000025884; -.
DR Ensembl; ENSMLET00000049418.1; ENSMLEP00000025884.1; ENSMLEG00000036379.1.
DR GeneTree; ENSGT00940000160103; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR CDD; cd15988; 7tmB2_BAI2; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1587
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014459943"
FT TRANSMEM 936..957
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 969..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1038..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1076..1103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1124..1142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1154..1174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1181..1201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 521..591
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 932..1206
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 229..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1358..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1422..1454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1500..1587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1587 AA; 172706 MW; 95CB412F21D8F188 CRC64;
MENTGWMGKG HRMTPACPLL LSVILSLRLA AAFDPAPSAC SALASGVLYG AFSLQDLFPT
IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL DHYLVNFTCL RPSPEEAVAQ
AESEVGRPEE EEAEAAAGLE LCSGSGPFTF LHFDKNFVQL CLSAEPSEAP RLLAPAALAF
RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSATTTSPG
PPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP
GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR ETRPCNNSAT
CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA CEGPELQTKL CSMAACPVEG
QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG PAWATCTGAL TDTRECSNLE CPATDSKWGP
WNAWSLCSKT CDTGWQRRFR MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM
LMTWKKAAAG EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR
EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF KRATYVPSAD
DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED FIHLVGDALK AFQSSLIVTD
NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRHSEDRLF LPKEVLSLSS PGKPATSGAA
GSPGRGRGPG TVPPGPGHSH QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR
VMTVTVRPPT QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ
AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL LAIYAAFWRF
IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA AFLHFFFLSS FCWVLTEAWQ
SYLAVIGRMR TRLVRKRFLC LGWGLPALVV AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF
VGPAAVIVLV NMLIGIIVFN KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP
LLSSASARNA MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA
VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA CQTVLFKEVN
TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG NILVPMAASP GLGEPPPPQE
ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS LQPGGGGGGG EDAPRARPEG
TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE
RSRTMPRTVP GSTMKMGSLE VRGCREWGVC LRLCKVMHTR KRHSELYHEL NQKFHTFDRY
RSQSTAKREK RWSVSSGGAA ERSVCTDKPS PGERPSLSQH RRHQSWSTFK SMTLGSLPPK
PRERLTLHRT AAWEPTEPPD GDFQTEV
//
