ID   A0A2K5ZFT8_MANLE        Unreviewed;       347 AA.
AC   A0A2K5ZFT8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Proline rich transmembrane protein 2 {ECO:0000313|Ensembl:ENSMLEP00000026686.1};
GN   Name=PRRT2 {ECO:0000313|Ensembl:ENSMLEP00000026686.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000026686.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000026686.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CD225/Dispanin family.
CC       {ECO:0000256|ARBA:ARBA00006843}.
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DR   AlphaFoldDB; A0A2K5ZFT8; -.
DR   STRING; 9568.ENSMLEP00000026686; -.
DR   Ensembl; ENSMLET00000050227.1; ENSMLEP00000026686.1; ENSMLEG00000037542.1.
DR   GeneTree; ENSGT00940000161103; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0043679; C:axon terminus; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
DR   GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
DR   GO; GO:0017075; F:syntaxin-1 binding; IEA:Ensembl.
DR   GO; GO:1905513; P:negative regulation of short-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0035544; P:negative regulation of SNARE complex assembly; IEA:Ensembl.
DR   GO; GO:0050884; P:neuromuscular process controlling posture; IEA:Ensembl.
DR   GO; GO:0150037; P:regulation of calcium-dependent activation of synaptic vesicle fusion; IEA:Ensembl.
DR   GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IEA:Ensembl.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   PANTHER; PTHR14948; NG5; 1.
DR   PANTHER; PTHR14948:SF20; PROLINE-RICH TRANSMEMBRANE PROTEIN 2; 1.
DR   Pfam; PF04505; CD225; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        268..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        313..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..161
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..211
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   347 AA;  35653 MW;  B3898B9202749765 CRC64;
     MAASSSEVSE MKGVEESPEV PGKGPGHSEA ETGPPQVLAG VPDQPEAPQP GPDTTAALVD
     SGPKAGLAPE TPETPAGASE TAQATDLSLS PGGESKANCS PKQPCQETVS KPEVSKEATA
     DQGSRLESAA PPEPAPEPAP QPDPQPDSQP TPKPAIQPAL PTQEDPTPEI LSESVEEKQE
     NGAVVPLQAG DGEEGPAPEP HSPPSKKSPP ANGAPPRVLQ QLVEEDRMGR AHSGHPGSPR
     GSLSRHPSSQ LAGPGVEGGE GTQKPRDYII LAILSCFCPM WPVNIVAFAY AVMSRNSLQQ
     GDVDGAQRLG RVAKLLSIVA LVGGVLIIIA SCVINLGVYR HEPLHPA
//