ID A0A2K5ZFX1_MANLE Unreviewed; 177 AA.
AC A0A2K5ZFX1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Interleukin-7 {ECO:0000256|ARBA:ARBA00019460, ECO:0000256|PIRNR:PIRNR001942};
DE Short=IL-7 {ECO:0000256|PIRNR:PIRNR001942};
GN Name=IL7 {ECO:0000313|Ensembl:ENSMLEP00000026635.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000026635.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000026635.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Hematopoietic cytokine that plays an essential role in the
CC development, expansion, and survival of naive and memory T-cells and B-
CC cells thereby regulating the number of mature lymphocytes and
CC maintaining lymphoid homeostasis. {ECO:0000256|PIRNR:PIRNR001942}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR001942}.
CC -!- SIMILARITY: Belongs to the IL-7/IL-9 family.
CC {ECO:0000256|ARBA:ARBA00007621, ECO:0000256|PIRNR:PIRNR001942}.
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DR RefSeq; XP_011844456.1; XM_011989066.1.
DR AlphaFoldDB; A0A2K5ZFX1; -.
DR SMR; A0A2K5ZFX1; -.
DR STRING; 9568.ENSMLEP00000026635; -.
DR Ensembl; ENSMLET00000050176.1; ENSMLEP00000026635.1; ENSMLEG00000037494.1.
DR GeneID; 105545992; -.
DR KEGG; mleu:105545992; -.
DR CTD; 3574; -.
DR GeneTree; ENSGT00390000004451; -.
DR OMA; NMSAEYR; -.
DR OrthoDB; 4630779at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR Gene3D; 1.20.1250.50; -; 1.
DR InterPro; IPR001181; IL-7.
DR InterPro; IPR038325; IL7_sf.
DR PANTHER; PTHR48404; INTERLEUKIN-7; 1.
DR PANTHER; PTHR48404:SF1; INTERLEUKIN-7; 1.
DR Pfam; PF01415; IL7; 1.
DR PIRSF; PIRSF001942; IL-7; 1.
DR PRINTS; PR00435; INTERLEUKIN7.
DR SMART; SM00127; IL7; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR001942};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001942-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR001942};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001942};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..177
FT /note="Interleukin-7"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014371558"
FT DISULFID 27..166
FT /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
FT DISULFID 59..154
FT /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
FT DISULFID 72..117
FT /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
SQ SEQUENCE 177 AA; 20230 MW; 11D6717E8B633424 CRC64;
MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD SMKEIGSNCL
NNEFNFFKRH LCDDNKEGMF LFRAARKLRQ FLKMNSTGDF DLHLLKVSEG TTILLNCTGK
VKGRKPAALG EPQPTKSLEE NKSLKEQKKL NDSCFLKRLL QKIKTCWNKI LMGTKEH
//
