ID A0A2K5ZG54_MANLE Unreviewed; 1116 AA.
AC A0A2K5ZG54;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=MDS1 and EVI1 complex locus {ECO:0000313|Ensembl:ENSMLEP00000026778.1};
GN Name=MECOM {ECO:0000313|Ensembl:ENSMLEP00000026778.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000026778.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000026778.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A2K5ZG54; -.
DR Ensembl; ENSMLET00000050321.1; ENSMLEP00000026778.1; ENSMLEG00000037568.1.
DR GeneTree; ENSGT00940000157208; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24393:SF15; IP01201P-RELATED; 1.
DR PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 85..113
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 139..166
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 167..194
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 195..224
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 225..252
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 253..280
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 282..309
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 798..825
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 826..854
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 855..882
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 387..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..971
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 125834 MW; B8DDFE1A1078822F CRC64;
MILDEFYNVK FCIDASQPDV GSWLKYIRFA GCYDQHNLVA CQINDQIFYR VVADIAPGEE
LLLFMKSEDY PHETMAPDIH EERQYRCEDC DQLFESKADL ADHQKFPCST PHSAFSMVEE
DFQQKLESEN DLQEIHTIQE CKECDQVFPD LQSLEKHMLS HTEEREYKCD QCPKAFNWKS
NLIRHQMSHD SGKHYECENC AKQVFTDPSN LQRHIRSQHV GARAHACPEC GKTFATSSGL
KQHKHIHSSV KPFICEVCHK SYTQFSNLCR HKRMHADCRT QIKCKDCGQM FSTTSSLNKH
RRFCEGKNHF AAGGFFGQGI SLPGTPAMDK TSMVNMSHAN PGLADYFGAN RHPAGLTFPT
APGFSFSFPG LFPSGLYHRP PLIPASSPVK GLSSTEQTNK SQSPLMTHPQ ILPATQDILK
ALSKHPSVGD NKPVELQPER SSEERPLEKI SDQSESSDLD DVSTPSGSDL ETTSGSDLES
DIESDKEKFK ENGKMFKDKV SPLQNLASIN NKKEYSNHSI FSPSLEEQTA VSGAVNDSIK
AIASIAEKYF GSTGLVGLQD KKVGALPYPS MFPLPFFPAF SQSMYPFPDR DLRSLPLKME
PQSPGEVKKL QKGSSESPFD LTTKRKDEKP LTPVPSKPPV TPATSQDQPL DLSMGSRSRA
SGTKLTEPRK NHVFGEKKGS NVESRPASDG SLQHARPTPF FMDPIYRVEK RKLTDPLEAL
KEKYLRPSPG FLFHPQFQLP DQRTWMSAIE NMAEKLESFS ALKPEASELL QSVPSMFNFR
APPSALPENL LRKGKERYTC RYCGKIFPRS ANLTRHLRTH TGEQPYRCKY CDRSFSISSN
LQRHVRNIHN KEKPFKCHLC DRCFGQQTNL DRHLKKHENG NMSGTATSSP HSELESTGAI
LDDKEDAYFT EIRNFIGNSN HSSQSPRNVE ERMNGSHFKD EKALVTSQNS DLLDDEEVED
EVLLDEEDED NDITGKTGKE PVTSNLHEGN PEDDYEETSA LEMSCKTSPV RYKEEEYKSG
LSALDHIRHF TDSLKMRKME DNQYSEAELS SFSTSHVPEE LKQPLHRKSK SQAYAMMLSL
SDKESLHSTS HSSSNVWHSM ARAAAESSAI QSISHV
//
