ID   A0A2K5ZG78_MANLE        Unreviewed;      1268 AA.
AC   A0A2K5ZG78;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
GN   Name=DCTN1 {ECO:0000313|Ensembl:ENSMLEP00000026837.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000026837.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000026837.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00011010}.
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DR   AlphaFoldDB; A0A2K5ZG78; -.
DR   Ensembl; ENSMLET00000050380.1; ENSMLEP00000026837.1; ENSMLEG00000037196.1.
DR   GeneTree; ENSGT00940000155378; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR   InterPro; IPR036859; CAP-Gly_dom_sf.
DR   InterPro; IPR000938; CAP-Gly_domain.
DR   InterPro; IPR022157; Dynactin.
DR   PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR   PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR   Pfam; PF01302; CAP_GLY; 1.
DR   Pfam; PF12455; Dynactin; 1.
DR   SMART; SM01052; CAP_GLY; 1.
DR   SUPFAM; SSF74924; Cap-Gly domain; 1.
DR   PROSITE; PS00845; CAP_GLY_1; 1.
DR   PROSITE; PS50245; CAP_GLY_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          48..90
FT                   /note="CAP-Gly"
FT                   /evidence="ECO:0000259|PROSITE:PS50245"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          941..1032
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1268 AA;  140258 MW;  552FDB072AE1E290 CRC64;
     MAQSKRHVYS RTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV
     ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE
     GTDTTAKTSK LVSGLGPTRP ASTGVAGASS SLGPSGSASA GELSSSEPST PAQTPLAAPI
     IPTPALTSPG AVPPLPSPSK EEEGLRAQVR DLEEKLETLR LKRAEDKAKL KELEKHKIQL
     EQVQEWKSKM QEQQADLQRR LKEARKEAKE ALEAKERYME EMADTADAIE MATLDKEMAE
     ERAESLQQEV EALKERVDEL TTDLEILKAE IEEKGSDGAA SSYQLKQLEE QNARLKDALV
     RMRDLSSSEK QEHVKLQKLM EKKNQELEVV RQQRERLQEE LSQAESTIDE LKEQVDAALG
     AEEMVEMLTD RNLNLEEKVR ELRETVGDLE AMNEMNDELQ ENARETELEL REQLDMAGAR
     VREAQKRVEA AQETVADYQQ TIKKYRQLTA HLQDVNRELT NQQEASVERQ QQPPPETFDF
     KIKFAETKAH AKAIEMELRQ MEVAQANRHM SLLTAFMPDS FLRPGGDHDC VLVLLLMPRL
     ICKAELIRKQ AQEKFELSEN CSERPGLRGA AGEQLSFAAG LVYSLSLLQA TLHRYEHALS
     QCSVDVYKKV GSLYPEMSAH ERSLDFLIEL LHKDQLDETV NVEPLTKAIK YYQHLYSIHL
     AEQPEDCTMQ LADHIKFTQS ALDCMSVEVG RLRAFLQGGQ EATDIALLLR DLETSCSDIR
     QFCKKIRRRM PGTDAPGIPA ALAFGPQVSD TLLDCRKHLT WVVAVLQEVA AAAAQLIAPL
     AENEGLPVAA LEELAFKASE QVGLNGWAEG QGGWRFPWRS CRELLLVVGG QGDRRKKAGF
     PCNWISLKGP PPVELRAAAL RAEITDAEGL GLKLEDRETV IKELKKSLKI KGEELSEANV
     RLSLLEKKLD SAAKDADERI EKVQTRLEET QALLRKKEKD FEETMDALQA DIDQLEAEKT
     ELKQRLNSQS KRTIEGLRSP PPSGIATLVS GIAGGEYSGI GAVPGQAPGS VPGPGLVKDS
     PLLLQQISAM RLHISQLQHE NNILKGAQMK ASLASLPPLH VAKLSHEGPG SELPAGALYR
     KTSQLLETLN QLSTHTHVVD ITRTSPATKS PSAQLMEQVA QLKSLSDTIE KLKDEVLKET
     VSQRPGATVP TDFATFPSSA FLRAKEEQQD DTVYMGKVTF SCAAGLGQRH RLVLTQEQLH
     QLHSRLIS
//