ID A0A2K5ZGA3_MANLE Unreviewed; 1625 AA.
AC A0A2K5ZGA3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 1 {ECO:0000313|Ensembl:ENSMLEP00000026823.1};
GN Name=TRPM1 {ECO:0000313|Ensembl:ENSMLEP00000026823.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000026823.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000026823.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_011855961.1; XM_012000571.1.
DR Ensembl; ENSMLET00000050366.1; ENSMLEP00000026823.1; ENSMLEG00000037517.1.
DR GeneID; 105554211; -.
DR CTD; 4308; -.
DR GeneTree; ENSGT00940000155024; -.
DR OMA; IHTEYTS; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF13; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 853..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 920..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 950..968
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 988..1009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1072..1097
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..357
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 864..1106
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1201..1256
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 425..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1353..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1570..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1365..1401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1625 AA; 184712 MW; A91B831AB0CBD47D CRC64;
MGQKSWIEKT FCKRECIFVI PSTKDPNRCC CGQFTNQHIP PLPSATPSKN EEENKQVETQ
PEKWSVAKHT QSYPTDSYGV LEFQGGGYSN KAMYIRVSYD TKPDSLLHLM VKDWQLELPK
LLISVHGGLQ NFEMQPKLKQ VFGKGLIKAA MTTGAWIFTG GVSTGVISHV GDALKDHSSK
SRGRVCAIGI APWGIVENKE DLVGKDVTRV YQTMSNPLSK LSVLNNSHTH FILADNGTLG
KYGAEVKLRR LLEKHISLQK INTRLGQGVP LVGLVVEGGP NVVSIVLEYL REEPPVPVVI
CDGSGRASDI LSFAHKYCEE GGIINESLRE QLLVTIQKTF NYNKAQSHQL LAIIMECMKK
KELVTVFRMG SEGQQDIEMA ILTALLKGTN ASAPDQLSLA LAWNRVDIAR SQIFVFGPHW
PPLGSLAPPT DSKATEKEKK PATATTKGGR GKGKGKKKGK VKEEAEEETD PRKIELLNWV
NALEQAMLDA LVLDRVDFVK LLIENGVNMQ HFLTIPRLEE LYNTRLGPPN TLHLLVRDVK
KSNLPPDYHI SLIDIGLVLE YLMGGAYRCN YTRKNFRTLY NNLFGPKRPK ALKLLGMEDD
EPPAKGKKKK KKKKEEEIDI DVDDPAVSRF QYPFHELMVW AVLMKRQKMA VFLWQRGEES
MAKALVACKL YKAMAHESSE SDLVDDISQD LDNNSKDFGQ LALELLDQSY KHDEQIAMKL
LTYELKNWSN STCLKLAVAA KHRDFIAHTC SQMLLTDMWM GRLRMRKNPG LKVIMGILLP
PTILFLEFRT YDDFSYQTSK ENEDGKEKEE ENTDANADAG SRKGDEENEH KKQRSIPIGT
KICEFYNAPI VKFWFYTISY LGYLLLFNYV ILVRMDGWPS LQEWIVISYI VSLALEKIRE
ILMSEPGKLS QKIKVWLQEY WNITDLVAIS TFMIGAILRL QNQPYMGYGR VIYCVDIIFW
YIRVLDIFGV NKYLGPYVMM IGKMMIDMLY FVVIMLVVLM SFGVARQAIL HPEEKPSWKL
ARNIFYMPYW MIYGEVFADQ IDLYAMEINP PCGENLYDEE GKRLPPCIPG AWLTPALMAC
YLLVANILLV NLLIAVFNNT FFEVKSISNQ VWKFQRYQLI MTFHDRPVLP PPMIILSHIY
IIIMRLSGRC KKKREGDQEE RDRGLKLFLS DEELKRLHEF EEQCVQEHFR EKEDEQQSSS
DERIRVTSER VENMSMRLEE INERETFMKT SLQTVDLRLA QLEELSNRMV NALENLVGID
RSDLIQARSR ASSECEATYL LRQSSINSAD GYSLYRYHFN GEELLCEDTS LSMSPGTGVR
KKTCSFRIKE EKDGKTHLVP ECQNSLHLSL GTSTSATPDG SHLAADDLKN AEESKLGPDI
GISKEDDERQ TDSKKEETIS PSLSKTDVIH GQDKSDVQNT QLTVETTNIE GTISYPLEET
KITRYYPDET FNACKTMKSR SFVYSRGRKL VSGVNQDVEY SSIMDQQWTT EWQCQVQKIT
RSHSTDIPYI VSEAAVQAKH KEQFTDMEDE HHVAEATPRI PRLSLTITDR NGMENLLSVK
PDQTLGFPSL RSKSLHGHPR NVKSVQGKLD RSGHASSVSS LVIVSGMTAE EKKVKKEKAS
AETEC
//
