ID   A0A2K5ZGD9_MANLE        Unreviewed;       804 AA.
AC   A0A2K5ZGD9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN   Name=AMPD2 {ECO:0000313|Ensembl:ENSMLEP00000026858.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000026858.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000026858.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
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DR   RefSeq; XP_011824085.1; XM_011968695.1.
DR   AlphaFoldDB; A0A2K5ZGD9; -.
DR   SMR; A0A2K5ZGD9; -.
DR   Ensembl; ENSMLET00000050401.1; ENSMLEP00000026858.1; ENSMLEG00000037617.1.
DR   GeneID; 105530946; -.
DR   CTD; 271; -.
DR   GeneTree; ENSGT00950000183011; -.
DR   OrthoDB; 20951at2759; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF3; AMP DEAMINASE 2; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  92918 MW;  753154327F2740E4 CRC64;
     MWQSQAPAGA AQTPPLSPPW SQPWHPIHLA LASPRPNIPL RSGPACRPPL QLQELFTRSL
     AESELRSAPY EFPEESPIEQ LEERRQRLER QISQDVKLEP DILLRAKQDF LKTDSDSDLQ
     LYKEQGEGQG DRSLRERDVL EREFQRVTIS GEEKCGVPFT DLLDAAKSVV RALFIREKYM
     ALSLQSFCPT TRRYLQQLAE KPLETRTYEQ GPDTPVSADA PVHPPALEQH PYEHCEPSTM
     PGDLGLGLRM VRGVVHVYTR REPDEHCSEV ELPYPDLQEF VADVNVLMAL IINGPIKSFC
     YRRLQYLSSK FQMHVLLNEM KELAAQKKVP HRDFYNIRKV DTHIHASSCM NQKHLLRFIK
     RAMKRHLEEI VHVEQGREQT LREVFESMNL TAYDLSVDTL DVHADRNTFH RFDKFNAKYN
     PIGESVLREI FIKTDNRVSG KYFAHIIKEV MSDLEESKYQ NAELRLSIYG RSRDEWDKLA
     RWAVMHRVHS PNVRWLVQVP RLFDVYRTKG QLANFQEMLE NIFLPLFEAT VHPASHPELH
     LFLEHVDGFD SVDDESKPEN HVFNLESPLP EAWVEEDNPP YAYYLYYTFA NMAMLNHLRR
     QRGFHTFVLR PHCGEAGPIH HLVSAFMLAE NISHGLLLRK APVLQYLYYL AQIGIAMSPL
     SNNSLFLSYH RNPLPEYLSR GLMVSLSTDD PLQFHFTKEP LMEEYSIATQ VWKLSSCDMC
     ELARNSVLMS GFSHKVKSHW LGPNYTKEGP EGNDIRRTNV PDIRVGYRYE TLCQELALIT
     QAVQSEMLET IPEEAGITMS PGPQ
//