ID A0A2K5ZGT0_MANLE Unreviewed; 371 AA.
AC A0A2K5ZGT0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=G protein-coupled receptor 17 {ECO:0000313|Ensembl:ENSMLEP00000027026.1};
GN Name=GPR17 {ECO:0000313|Ensembl:ENSMLEP00000027026.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000027026.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000027026.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_011835878.1; XM_011980488.1.
DR AlphaFoldDB; A0A2K5ZGT0; -.
DR STRING; 9568.ENSMLEP00000027026; -.
DR Ensembl; ENSMLET00000050569.1; ENSMLEP00000027026.1; ENSMLEG00000037712.1.
DR GeneID; 105540000; -.
DR KEGG; mleu:105540000; -.
DR CTD; 2840; -.
DR GeneTree; ENSGT01100000263537; -.
DR OMA; TCLNGAM; -.
DR OrthoDB; 5383533at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IEA:Ensembl.
DR CDD; cd15161; 7tmA_GPR17; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24232; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24232:SF44; URACIL NUCLEOTIDE_CYSTEINYL LEUKOTRIENE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01157; P2YPURNOCPTR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..329
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 41340 MW; E1CE07F4AB5ECA51 CRC64;
MSKRSWWAGS RQPPRETLKL SGSYPGSDSS QSMNGLEVAP SGLITNFSLA TAEQCGQETP
LENMLFASFY LLDFILAFVG NTLALWLFIR DHKSGTPANV FLMHLAVADL SCVLVLPTRL
VYHFSGNHWP FGEIACRLTG FLFYLNMYAS IYFLTCISAD RFLAIVHPVK SLKLRRPLYA
HLACAFLWVV VAVAMAPLLV NQQTVQTNHT VVCLQLYREK ASHHALVSLA VAFTFPFVTT
VTCYLLIIRS LRQGLRVEKR LKSKAVRMIA IVLAIFLVCF VPYHVNRSVY VLHYRSGGTS
CATQRVLALG NRITSCLTSL NGALDPIMYF FVAEKFRHAL CNLLCGKRLK GPPPSFEGKT
NESSLSAKSE L
//
