ID   A0A2K5ZK51_MANLE        Unreviewed;       375 AA.
AC   A0A2K5ZK51;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Potassium channel subfamily K member {ECO:0000256|PIRNR:PIRNR038061};
GN   Name=KCNK3 {ECO:0000313|Ensembl:ENSMLEP00000028197.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000028197.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000028197.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|PIRNR:PIRNR038061}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|PIRNR:PIRNR038061}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC       ECO:0000256|RuleBase:RU003857}.
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DR   AlphaFoldDB; A0A2K5ZK51; -.
DR   STRING; 9568.ENSMLEP00000028197; -.
DR   Ensembl; ENSMLET00000051749.1; ENSMLEP00000028197.1; ENSMLEG00000038319.1.
DR   GeneTree; ENSGT00940000158248; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005252; F:open rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0022841; F:potassium ion leak channel activity; IEA:Ensembl.
DR   GO; GO:0044548; F:S100 protein binding; IEA:Ensembl.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR005406; KCNK3.
DR   PANTHER; PTHR11003:SF138; POTASSIUM CHANNEL SUBFAMILY K MEMBER 3; 1.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PIRSF; PIRSF038061; K_channel_subfamily_K_type; 1.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   PRINTS; PR01584; TASK1CHANNEL.
DR   PRINTS; PR01095; TASKCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003857};
KW   Ion transport {ECO:0000256|PIRNR:PIRNR038061,
KW   ECO:0000256|RuleBase:RU003857};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038061};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|PIRNR:PIRNR038061};
KW   Potassium channel {ECO:0000256|ARBA:ARBA00022826,
KW   ECO:0000256|PIRNR:PIRNR038061};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|PIRNR:PIRNR038061};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003857};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR038061}.
FT   TRANSMEM        59..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        92..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        135..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          58..113
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   DOMAIN          148..224
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
SQ   SEQUENCE   375 AA;  41493 MW;  659E5B3AE765516C CRC64;
     ARSQYIRNLG TAVLFFQGRQ RLELRQQELR ARYNLSQGGY EELERVVLRL KPHKAGVQWR
     FAGSFYFAIT VITTIGYGHA APSTDGGKVF CMFYALLGIP LTLVMFQSLG ERINTLVRYL
     LHRAKKGLGM RRADVSMANM VLIGFFSCIS TLCIGAAAFS HYEHWTFFQA YYYCFITLTT
     IGFGDYVALQ KDQALQTQPQ YVAFSFVYIL TGLTVIGAFL NLVVLRFMTM NAEDEKRDAE
     HRALLTRNGQ VGCGGGGGSA HTTDTASSTA AAGGGGFRNV YAEVLHFQSM CSCLWYKSRE
     KLQYSIPMII PRDLSTSDTC VEQSHSSPGA GGRYSDTPSR RCLCSGAPRS AISSVSTGLH
     SLSTFRGLMK RRSSV
//