ID A0A2K5ZKM8_MANLE Unreviewed; 937 AA.
AC A0A2K5ZKM8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=NLR family pyrin domain containing 4 {ECO:0000313|Ensembl:ENSMLEP00000028379.1};
GN Name=NLRP4 {ECO:0000313|Ensembl:ENSMLEP00000028379.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000028379.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000028379.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR AlphaFoldDB; A0A2K5ZKM8; -.
DR STRING; 9568.ENSMLEP00000028379; -.
DR Ensembl; ENSMLET00000051932.1; ENSMLEP00000028379.1; ENSMLEG00000038409.1.
DR GeneTree; ENSGT00940000162284; -.
DR OMA; THPDCRV; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0045824; P:negative regulation of innate immune response; IEA:Ensembl.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF6; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 8.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 1..94
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 149..281
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 937 AA; 107305 MW; AC7680EDF9596246 CRC64;
MAASFFSDFG LMWYLEELKK EEFRKFKEYL KQMTLHLELK QIPWTEVKKA SREELANLLI
KHYEEQQAWN ITLRIFQKMD RKDLCMKVMR ERTGYTQTYQ AHAKRKFSHL WASKSVTEIH
LYFQEEVKQE ECEHLDHLFA PKETGKQPRT VIIQGPQGIG KTTLLMKLLM AWSDNRIFRD
RFLYTFYFCC RELRELPATS LADLISREWP DPAAPVTEIV SQPERLLFVI DSFEELKDGL
NEPDSALCDD VTEKRPVQVL LSSLLRKKVL PEASLLVAVQ PVCPKELRDR VAISEIYEPR
GFNESDRLVY FCCFFKDPKR AMEAFSVVRE SEQLFSICQI PLLCWILCTS LKQEMQKGKD
LTLTCQSTTS VYSCFIFNLF TPEGAEGPTP QSQRQLKALC SLAAEGMWTD TFEFREDDLR
RNGVVDTDIP ALLGTKVLLK YGERESSYVF LHACIQEFCA ALFYLLRSHL DHPHPAVRSV
QELLVANFEK TRRARWIFLG CFLTGLLNRQ EQQKLDAFFG FQLSQEIKQQ LHQCLKSLGE
HGDPLGQVDS LAIFYCLFEM QDPAFVKQAV NLLQKADFHI IDNADLVVSA YCLKYCSSLR
KLSFSVQNVF KKEDEHSSTS DYSLVCWHHI CSVLTTSGHL TELQVQDSTL SESTFVTWCN
QLRHPSCRLQ RLGINNVSFS GPSGQLFEVL FYQPDLKYLS FTLTKLSRDD VRSLCDALNY
PAGNVKELAL VDCFLSPIDC EVLACLLTNN KKLTYLNVSC NDLDAGLPLL CEALCNPDTV
LVYLMLAYCH LSEQCCEYIS EMLLHNKSVR YLDLGANVLK DEGLKTLCEA LKRPDCRLDS
LCLVKCFITV AGCEDLASAL ISNQNLKILQ IGCNEIGDVG VKLLCGALTH PNCRLEVLGL
RKTDFDEETQ ALLMAEEERN PNLTITDDCD TVTRVEI
//
