ID A0A2K5ZM88_MANLE Unreviewed; 3277 AA.
AC A0A2K5ZM88;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Laminin subunit alpha 3 {ECO:0000313|Ensembl:ENSMLEP00000028909.1};
GN Name=LAMA3 {ECO:0000313|Ensembl:ENSMLEP00000028909.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000028909.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000028909.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; XP_011843472.1; XM_011988082.1.
DR Ensembl; ENSMLET00000052463.1; ENSMLEP00000028909.1; ENSMLEG00000038499.1.
DR GeneID; 105545233; -.
DR CTD; 3909; -.
DR GeneTree; ENSGT00940000155638; -.
DR OrthoDB; 90222at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 14.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 12.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF365; NETRIN-A-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 12.
DR Pfam; PF02210; Laminin_G_2; 5.
DR Pfam; PF06008; Laminin_I; 2.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 14.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 9.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..3277
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014429600"
FT DOMAIN 43..298
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 426..469
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 491..535
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 536..588
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 631..683
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1266..1311
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1356..1404
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1405..1455
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1476..1653
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1687..1733
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1734..1786
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2334..2535
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2542..2704
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2711..2871
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2930..3094
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3101..3274
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 1853..1915
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1965..2006
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2042..2113
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2269..2327
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 445..454
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 491..503
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 511..520
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 536..548
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 538..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 557..566
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 654..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1266..1278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1268..1285
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1287..1296
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1380..1389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1405..1417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1407..1424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1426..1435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1706..1715
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1734..1746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1757..1766
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 3277 AA; 360125 MW; AC36DE6ED8F6EEF9 CRC64;
MAAAARPRGR APGPVLPPTP LLLLVLQLLP AWGATARDPR AAAGLSLHPP YFNLAEAARI
WATATCGERG PSERRPRPEL YCKLVGGPTA PGSGHTIQGQ FCDYCNSEDP RKAHPVTNAI
DGSERWWQSP PLSSGTQYNR VNLTLDLGQL FHVAYILIKF ANSPRPDLWV LERSVDFGST
YSPWQYFAHS KVDCLKEFGQ EANMAVTRDD DVLCVTEYSR IVPLENGEVV VSLINGRPGA
KNFTFSHTLR EFTKATNIRL RFLRTNTLLG HLISKAQRDP TVTRRYYYSI KDISIGGRCV
CNGHAEVCNA NNPEKLFRCQ CQHHTCGETC DRCCTGYNQR RWRPAAWEQS HECEACNCHG
HASDCYYDSD IERQQASLNT QGIYAGGGVC INCQHNTAGV NCEQCAKGYY RPYGVPVDAP
DGCIPCSCDP EHADGCEQGS GRCHCKPNFH GDNCEKCAAG YYNFPFCLKI PIFPVSTPSP
EDPVAGDIRG CDCNLEGVLP EICDAHGRCL CRPGVEGPRC DTCRSGFYSF PICQACWCSA
LGSYQMPCSS VTGQCECRPG VTGQRCDRCL SGAYDFPHCQ GSSSACDPAG TIDSNLGSCP
CKLHVEGPTC SICKPLYWNL DKENPNGCSE CQCHKAGTVS GTGECRQGDG DCHCKSHVGG
DSCDTCEDGY FALEKSNYFG CQGCQCDIGG ALSSVCSGPS GVCQCREHVV GKACQRPENN
YYFPDLHHMK YEIEDGSTPN GRDLRFGFDP LAFPGFSWRG YAQMTSVQND VRITLNVGKS
SGSLFHVILR YINPGTEAVS GHITIYPSWG AAQSKEIIFL PSKEPAFVTV PGNGFADPFS
ITPGIWVACI KAEGVLLDYL VLLPRDYYEA SVLQLPVTEP CAYAGPPQEN CLLYQHLPVT
RFPCTLACEA RHFLLDGEPR PVAVRQPTPA HPVMVDLSGR EVELHLRLHV PQVGRYVVVL
EYSTEAAQLF VADVNVKSSG SVLAGQVNIY SCKYSVLCRS AVIDHMSRIA VYELLADADI
QLKGHMARFL LHQVCVIPIE EFSAEYVRPQ VHCIASYRPF VNQSATCVSL AHETPPTALI
LDVVSGRPFP HLPQQSSPSV DVLPGVTLKA PQNQVTLRGR APHLGRYVFV IHFYQAAHPT
FPAQVSVDGG WPRAGSFRAS FCPHVLGCRD QVIAEGQIEF DISEPEVAAT VKVPEGKSLV
LVRILMVPIE NYDYQILHKK SMDKSLEFIT NCGKNSFYID PQTASRFCKN SARSLVAFYH
KGALPCECHP AGATSPHCSP EGGQCPCRPN VIGRQCTRCA TGHYGFPHCK PCSCGLRLCE
EMTGQCRCPP RTVRPQCEVC ETHSFSFHPM AGCEGCNCSR RGTSEAAMLE CDRDSGQCRC
KPRITGRQCD RCASGFYRFP ECVPCNCNRD GTEPGVCDPG TGVCLCKENV EGTECNVCRE
GSFHLDPANP KGCTSCFCFG VNNQCHSSHK RRAKFVDMLG WRLETADRMD IPVSFNPGSN
SMVADLQELP ATVHSASWVA PASYLGDKVS SYGGYLTYQA KSFGLPSDMV LLEKKPDVQL
TGHHMSVIYE ETNTPRPDRL HHGRVQVVEG NFRHASSRAP VSRQELMTVL SRLADMRIQG
LYFTETQRLT LSEVGLEEAS DTGSGRIAYA VEMCACPPAY AGDSCQGCSP GYYRDHKGLY
TGRCVPCNCN GHSNRCQDGS GICVNCQHNT AGEHCERCQE GYYGNAVHGS CRACPCPHTN
RFATGCVVNG GDVRCSCKAG YTGTQCERCA PGYFGNPQKF GGSCQPCSCN NNGQLGSCDP
LTGDCINQEP KDSSPAEECD DCDSCVMTLL NDLATMGEQL RLVKSQLQGL SASAGLLEQM
RHVETQAKDL RNQLLNYRST ISNHGSKIEG LERELTDLNQ EFETLQEKAQ VNSRKAQTLY
NNVNRAIQSA KELDMKIKTV IRNVHMLNRI RTWQKTHQGE NNGLANSIRD SLNEYEAKLS
DLRARLQEAA ARAKQANGLN QENERALGAI QRQVKEINSL QSDFTKYLTS ADSSLLQTNI
ALQLMEKSQK EYEKLAASLN EARQELSDKV RELSRSAGKT SLVEEAEKHA QSLQELAKQL
EEIKRNASGD ELVRCAVDAA TAYENILNAI KAAEDAANRA ASASESALQT VIKEDLPRKA
KTLSTNSDKL LNEAKMTQKK LKQEVSPALS NLQQTLNIVT VQREVIATNL TTLRDGLRGI
QRGDIDAMIS SAKSMVRKAN DITDEVLDGL NPIQTDVERI KDTYGSTQNE DFKKALTDAD
NSVNKLTNKL PDLWRKIESI NQQLLPLGNI SDNMDRIREL IQQARDAASK VAVPMRFNGK
SGVEVRLPND LEDLKGYTSL SLFLQRPNSR ENGGTENMFV MYLGNKDASR DYIGMAVVDG
QLTCVYNLGD HETELQVDQI LTESETQEAV MDRVKFQRIY QFARLNYTKG ATSSKPEIPG
VYDMDGRNSN TLLNLDPENV VFYVGGYPPD FKLPSRLRFP PYKGCIELDD LNENVLSLYN
FKKTFNLNTT EVEPCRRRKE ESDKNYFEGT GYARVPTQPH ASIPTFGQTI QTTVDRGLLF
FAENGDRFIS LNIEDGKLMV RYKLNSEPPK ERGVGDAINN GRDHSIQIKI GKVQKRMWIN
VDFQNTIIDG EVFDFSTYYL GGIPIAIRER FNISTPAFRG CMKNLKKTSG VVRLNDTVGV
TKKCSEDWKL VRSASFSRGG QLSFTNLGSP LTDHLQASFG FQTFQPSGIL LSHQTWTSTL
QVTLEDGHIE LSTRDSGSPI FKSPQTYMDG LLHYVSVISD NSGLRLLIDD QPLRNNQRPN
RISSSQQSLR LGGSNFEGCI SNVFVQRLSV SPEVLDLASN SLKRDVSLGG CSLNKPPFLM
LLQGSTRFNK AKTSRINQLL QDTPVASPGS MKVWQDACSP LPRTQANHGA LQFGDIPTSH
LLFKLPQELL KPRSQFAVDV QTTSSRGLVF HTGTKNSFMA LYLSKGRLVF ALGTDGKKLR
IKSKEKCNDG KWHTVVFGHD GEKGRLVVDG LRAREGSLPG NSTISIRGPV YLGSPPSGKP
KSLPTNSFVG CLKNFQLDSK PLDTPSSSFG VSSCLGGPLE KGIYFSEEGG HVILAHSVLL
GPEFKLVFSI RPRSLTGILI HIGSQPGKHL CVYLEAGKVT ASMDSGAGGT STSVTPKQSL
CDGQWHSVAV TIKQHILHLE LDTDSSYTAG QIPFPPASTQ EPLHLGGAPA NLTTLRIPVW
KSFFGCLRNI FVNHIPVPVT EALEVQGPVS LNGCPDH
//
