ID A0A2K5ZMA4_MANLE Unreviewed; 318 AA.
AC A0A2K5ZMA4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=ArfGAP with dual PH domains 1 {ECO:0000313|Ensembl:ENSMLEP00000028915.1};
GN Name=ADAP1 {ECO:0000313|Ensembl:ENSMLEP00000028915.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000028915.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000028915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5ZMA4; -.
DR STRING; 9568.ENSMLEP00000028915; -.
DR Ensembl; ENSMLET00000052469.1; ENSMLEP00000028915.1; ENSMLEG00000038652.1.
DR GeneTree; ENSGT00940000155698; -.
DR OMA; YMAIRCA; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IEA:InterPro.
DR CDD; cd13252; PH1_ADAP; 1.
DR CDD; cd01251; PH2_ADAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037849; PH1_ADAP.
DR InterPro; IPR037851; PH2_ADAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46021:SF5; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46021; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..98
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 196..300
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 318 AA; 37151 MW; 7D4023132C728146 CRC64;
PDWASYTLGV FICLSCSGIH RNIPQVSKVK SVRLDAWDEA QVEFLASHGN DAARARFESK
VPSFYYRPTP SDCQLLREQW IRAKYERQEF IYPEKQEPYS AGYREGFLWK RGRDNGQFLS
RKFVLTEREG ALKYFNRNDA KEPKAVMKIE HLNATFQPAK IGHPHGLQVT YLKDNSTRNI
FIYHEDGKLV PKLSRNYLKE GYMEKTGPKQ TEGFRKRWFT MDDRRLMYFK DPLDAFARGE
VFIGSKESGY TVLHGFPPST QGHHWPHGIT IVTPDRKFLF ACETESDQRE WVAAFQKAVD
RPMLPQEYAV EAHFKHKP
//
