ID A0A2K5ZPE1_MANLE Unreviewed; 94 AA.
AC A0A2K5ZPE1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Mammalian defensins domain-containing protein {ECO:0000259|PROSITE:PS00269};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000029692.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000029692.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the alpha-defensin family.
CC {ECO:0000256|ARBA:ARBA00006519}.
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DR RefSeq; XP_011851060.1; XM_011995670.1.
DR AlphaFoldDB; A0A2K5ZPE1; -.
DR STRING; 9568.ENSMLEP00000029692; -.
DR Ensembl; ENSMLET00000053251.1; ENSMLEP00000029692.1; ENSMLEG00000039048.1.
DR GeneID; 105550687; -.
DR GeneTree; ENSGT00940000153268; -.
DR OMA; CHCSRTF; -.
DR OrthoDB; 4705779at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_N.
DR InterPro; IPR006080; Beta/alpha-defensin_C.
DR PANTHER; PTHR11876; ALPHA-DEFENSIN 1; 1.
DR PANTHER; PTHR11876:SF6; DEFENSIN-5; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM01418; Defensin_propep; 1.
DR SMART; SM00048; DEFSN; 1.
DR SUPFAM; SSF57392; Defensin-like; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 3: Inferred from homology;
KW Antibiotic {ECO:0000256|ARBA:ARBA00023022};
KW Antimicrobial {ECO:0000256|ARBA:ARBA00022529};
KW Defensin {ECO:0000256|ARBA:ARBA00022940};
KW Fungicide {ECO:0000256|ARBA:ARBA00022577};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..94
FT /note="Mammalian defensins domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014442309"
FT DOMAIN 65..93
FT /note="Mammalian defensins"
FT /evidence="ECO:0000259|PROSITE:PS00269"
SQ SEQUENCE 94 AA; 10468 MW; B1C5667CAC53E3D2 CRC64;
MRTLAILAAI LLFALQAQAE SLQERADEAA TQEQPGEDDQ DLAVSFEENG LSTLRASGSQ
ARRTCYCRTG RCYTPEFHSG KCLFKGRTYK LCCR
//
