ID A0A2K5ZQA0_MANLE Unreviewed; 734 AA.
AC A0A2K5ZQA0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Rho related BTB domain containing 2 {ECO:0000313|Ensembl:ENSMLEP00000029980.1};
GN Name=RHOBTB2 {ECO:0000313|Ensembl:ENSMLEP00000029980.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000029980.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000029980.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011824207.1; XM_011968817.1.
DR AlphaFoldDB; A0A2K5ZQA0; -.
DR Ensembl; ENSMLET00000053542.1; ENSMLEP00000029980.1; ENSMLEG00000039169.1.
DR GeneID; 105531025; -.
DR KEGG; mleu:105531025; -.
DR CTD; 23221; -.
DR GeneTree; ENSGT00940000158918; -.
DR OrthoDB; 2898387at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd18531; BACK_RHOBTB2; 1.
DR CDD; cd18356; BTB1_POZ_RHOBTB2; 1.
DR CDD; cd18359; BTB2_POZ_RHOBTB2; 1.
DR CDD; cd01873; RhoBTB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR PANTHER; PTHR24072:SF137; RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00651; BTB; 3.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00225; BTB; 2.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54695; POZ domain; 2.
DR PROSITE; PS50097; BTB; 2.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 273..449
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 507..574
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 313..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 83426 MW; E1F7EB376A49C5EE CRC64;
MKAWSRLMDS DMDYERPNVE TIKCVVVGDN AVGKTRLICA RACNATLTQY QLLATHVPTV
WAIDQYRVCQ EVLERSRDVV DDVSVSLRLW DTFGDHHKDR RFAYGRSDVV VLCFSIANPN
SLHHVKTMWY PEIKHFCPRA PVILVGCQLD LRYADLEAVN RARRPLARPI KPNEILPPEK
GREVAKELGI PYYETSVVAQ FGIKDVFDNA IRAALISRRH LQFWKSHLRN VQRPLLQAPF
LPPKPPPPII VVPDPPSSSE ECPAHLLEDP LCADVILVLQ ERVRIFAHKI YLSTSSSKFY
DLFLMDLSEG ELGGPSGPGG ACPEDHQGHP DQHHHHHHHH HGRDFLLRAA SFDVCESVDE
PGGSGPAGLR ASTSDGILRG NGTGYLPGRG RVLSSWSRAF VSIQEEMAED PLTYKSRLMV
VVKMDNSIQP GPFRAVLKYL YTGELDENER DLMHIAHIAE LLEVFDLRMM VANILNNEAF
MNQEITKAFH VRRTNRVKEC LAKGTFSDVT FILDDGTISA HKPLLISSCD WMAAMFGGPF
VESSTREVVF PYTSKSCMRA VLEYLYTGMF TSSPDLDDMK LIILANRLCL PHLVALTEQY
TVTGLMEATQ MMVDIDGDVL VFLELAQFHC AYQLADWCLH HICTNYNNVC RKFPRDMKAM
SPENQEYFEK HRWPPVWYLK EEDHYQRARK EREKEDYLHL KRQPKRRWLF WNSPSSPSSS
AASSSSPSSS SAVV
//
