ID   A0A2K5ZQI3_MANLE        Unreviewed;       839 AA.
AC   A0A2K5ZQI3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Desmocollin 3 {ECO:0000313|Ensembl:ENSMLEP00000030076.1};
GN   Name=DSC3 {ECO:0000313|Ensembl:ENSMLEP00000030076.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000030076.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000030076.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5ZQI3; -.
DR   Ensembl; ENSMLET00000053638.1; ENSMLEP00000030076.1; ENSMLEG00000039218.1.
DR   GeneTree; ENSGT01030000234624; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 3.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR014868; Cadherin_pro_dom.
DR   PANTHER; PTHR24027:SF80; CADHERIN-13; 1.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   Pfam; PF00028; Cadherin; 4.
DR   Pfam; PF08758; Cadherin_pro; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   PRINTS; PR01820; DESMOCOLLIN.
DR   SMART; SM00112; CA; 5.
DR   SMART; SM01055; Cadherin_pro; 1.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..839
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014475233"
FT   TRANSMEM        691..715
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          136..243
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          244..355
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          356..475
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          472..577
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          594..676
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   839 AA;  93254 MW;  5E55CA5E64CBB6DC CRC64;
     MAAAGLRRSV RGAACRQLLL TLVIFSLAGE ACKKVILNVP SKLEADKIIG RVNLEECFRS
     ADLIQSSDPD FRVLSDGSVY TARAVVLSDE KRSFTIRLSD KRKQTQKEVT VLLEHQKKVL
     KTRHTRETVL RRAKRRWAPI PCSMQENSLG PFPLFLQQVE SDAAQNYTVF YSISGRGVDQ
     EPLNLFYIER DTGNLFCTQP VDREEYDVFD LIAYASTADG YSADLPLPLP IRVEDENDNH
     PVFTEAIYNF EVSESSRLGT TVGVVCATDR DEPDTMHTRL KYSILQQTPR SPGLFSVHPS
     TGVITTVSHY LDREVVDKYS LIMKVQDMDG QFFGLIGTST CIITVTDSND NAPTFRQNAY
     EAFVEENAFN VEILRIPVED KDLINTANWR VNFTILKGNE NGHFKISTDK ETNEGVLCVV
     KPLNYEENHQ VNLEIGVNNE APFTRDIPRV TALNRALVTV HVRDLDEGPE CTPAAQYVRI
     KENLAVGSKI NGYKAYDPET RNGNGLRYKK LHDPKGWITI DEISGSIITS KILDREVETP
     KNELYNITVL AIDKDNRSCT GTLAVDIEDV NDNPPEILQE YVVICKPKMG YTDILAVDPD
     EPVHGAPFYF SLPNTSPEIS RLWSLTKVND TAARLSYQKN AGFQEYTIPI TVKDRAGQAA
     TKLLRVNLCE CTHPAQCRVT SRSAGVVLGK WAILAILLGI ALLFSVLLTL VCGVLGATKG
     KRFPEDLAQQ NLIISNTEAP GDDRVCSANG FMTQTANNSS QGFCGTMGSG MKNGGQETIE
     MMKGGNQTLE SCRGAGHHHT LDSCRGGHTE VDNCRYTYSE WHSFTQPRLG EESIRGHTG
//