ID A0A2K5ZQN0_MANLE Unreviewed; 136 AA.
AC A0A2K5ZQN0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Interleukin-4 {ECO:0000256|ARBA:ARBA00019467};
DE AltName: Full=B-cell stimulatory factor 1 {ECO:0000256|ARBA:ARBA00031287};
DE AltName: Full=Lymphocyte stimulatory factor 1 {ECO:0000256|ARBA:ARBA00030247};
GN Name=IL4 {ECO:0000313|Ensembl:ENSMLEP00000030114.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000030114.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000030114.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family.
CC {ECO:0000256|ARBA:ARBA00009855}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5ZQN0; -.
DR Ensembl; ENSMLET00000053676.1; ENSMLEP00000030114.1; ENSMLEG00000039248.1.
DR GeneTree; ENSGT00390000013108; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; INTERLEUKIN-4; 1.
DR PANTHER; PTHR47401:SF1; INTERLEUKIN-4; 1.
DR Pfam; PF00727; IL4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 3: Inferred from homology;
KW B-cell activation {ECO:0000256|ARBA:ARBA00022936};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..136
FT /note="Interleukin-4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014361444"
FT REGION 68..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 136 AA; 14678 MW; 868020B9421386FF CRC64;
MGLTSQLLPP LFFLLACAGN FAHGHNCHIA LREIIETLNS LTEQKTLCTK LTITDILAAS
KQHACLPTSR HSGSICRPPP ARVPSTSTRP QSTERTQLRR KPSAGLRLCS GSSTATMRRT
LAAWVRLHSS STGTSS
//
