ID A0A2K5ZRP9_MANLE Unreviewed; 434 AA.
AC A0A2K5ZRP9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Methylcrotonyl-CoA carboxylase subunit 1 {ECO:0000313|Ensembl:ENSMLEP00000030492.1};
GN Name=MCCC1 {ECO:0000313|Ensembl:ENSMLEP00000030492.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000030492.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000030492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5ZRP9; -.
DR Ensembl; ENSMLET00000054057.1; ENSMLEP00000030492.1; ENSMLEG00000039351.1.
DR GeneTree; ENSGT00940000156941; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 10..434
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 129..326
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 434 AA; 48161 MW; 1C566884AB30AF3A CRC64;
MKYTTTTGRN ITKVLIANRG EIACRVMRTA RKLGVQSVAV YSEADRNSMH VDMADEAYSI
GPAPSQQSYL SMEKIIQVAK TSAAQAIHPG YGFLSENMEF AELCKQEGII FIGPSPSAIR
DMGIKSTSKS IMAAAGVPVV EGYHGEDQSD QCLKEHAGRI GYPVMIKAVR GGGGKGMRIV
RSEQEFQEQL ESARREAKKS FSDDAVLIEK FVDTPRHVEV QVFGDHHGNA VYLFERDCSV
QRRHQKIIEE APAPGIKPEV RKKLGEAAVR AAKAVNYVGA GTVEFIMDSK HNFYFMEMNT
RLQVEHPVTE MITGTDLVEW QLRIAAGEKI PLSQEEITLQ GHAFEARIYA EDPSNNFMPG
AGPLVHLSTP RADPSTRIET GVRQGDEVSV HYDPMIAKLV VWAADRQAAL TKLRYSLRQY
NINSLHFHLA VEED
//
