ID A0A2K5ZRZ9_MANLE Unreviewed; 380 AA.
AC A0A2K5ZRZ9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698};
GN Name=SEPTIN1 {ECO:0000313|Ensembl:ENSMLEP00000030566.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000030566.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000030566.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Filament-forming cytoskeletal GTPase.
CC {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SUBUNIT: Septins polymerize into heterooligomeric protein complexes
CC that form filaments. {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}.
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DR AlphaFoldDB; A0A2K5ZRZ9; -.
DR STRING; 9568.ENSMLEP00000030566; -.
DR Ensembl; ENSMLET00000054132.1; ENSMLEP00000030566.1; ENSMLEG00000039481.1.
DR GeneTree; ENSGT00940000161794; -.
DR OMA; EMKGSIP; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0072687; C:meiotic spindle; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0051311; P:meiotic metaphase chromosome alignment; IEA:Ensembl.
DR GO; GO:0007056; P:spindle assembly involved in female meiosis; IEA:Ensembl.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF6; SEPTIN-1; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006698};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR006698};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR006698-
KW 2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR006698-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 69..309
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 313..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 191
FT /note="Important for dimerization"
FT /evidence="ECO:0000256|PIRSR:PIRSR006698-2"
SQ SEQUENCE 380 AA; 42876 MW; 3E1332CC6140609E CRC64;
MSHHDNGVTV GLGIQMCERW RVEAALSFLP HQRKWGETAG AVMAGGVMDK EYVGFAALPN
QLHRKSVKKG FDFTLMVAGE SGLGKSTLIN SLFLTNLYED RQVPEASARL TQTLAIERRG
VEIEEGGVKV KLTLVDTPGF GDSVDCSDCW LPVVKFIEEQ FEQYLRDESG LNRKNIQDSR
VHCCLYFISP FGRGLRPLDV AFLRAVHEKV NIIPVIGKAD ALMPQETQAL KQKESIPFAV
VGSCEVVRDG GKRPVRGRRY SWGTVEVENP HHCDFLNLRR MLVQTHLQDL KEVTHDLLYE
GYRARCLQSL ARPGARDRAS RSKLSRQSAT EIPLPMLPLA DTEKLIREKD EELRRMQEML
EKMQAQMQQS QAQGEQSDTL
//
