ID   A0A2K5ZW29_MANLE        Unreviewed;       674 AA.
AC   A0A2K5ZW29;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Dynein cytoplasmic 1 heavy chain 1 {ECO:0000313|Ensembl:ENSMLEP00000032020.1};
GN   Name=DYNC1H1 {ECO:0000313|Ensembl:ENSMLEP00000032020.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000032020.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000032020.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K5ZW29; -.
DR   Ensembl; ENSMLET00000055595.1; ENSMLEP00000032020.1; ENSMLEG00000040100.1.
DR   GeneTree; ENSGT00940000156103; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF12777; MT; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          1..56
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          144..475
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   DOMAIN          504..655
FT                   /note="Dynein heavy chain ATP-binding dynein motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12781"
FT   COILED          148..196
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          345..442
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   674 AA;  77708 MW;  0BA988B270D85C85 CRC64;
     MNGLSVYQIK VHRKYTGEDF DEDLRTVLRR SGCKNEKIAF IMDESNVLDS GFLDKMDLEK
     PNYIVPDYMP VVYDKLPQPP SHREAIVNSC VFVHQTLHQA NARLAKRGGR TMAITPRHYL
     DFINHYANLF HEKRSELEEQ QMHLNVGLRK IKETVDQVEE LRRDLRIKSQ ELEVKNAAAN
     DKLKKMVKDQ QEAEKKKVMS QEIQEQLHKQ QEVIADKQMS VKEDLDKVEP AVIEAQNAVK
     SIKKQHLVEV RSMANPPAAV KLALESICLL LGESTTDWKQ IRSIIMRENF IPTIVNFSAE
     EISDAIREKM KKNYMSNPSY NYEIVNRASL ACGPMVKWAI AQLNYADMLK RVEPLRNELQ
     KLEDDAKDNQ QKANEVEQMI RDLEASIARY KEEYAVLISE AQAIKADLAA VEAKVNRSTA
     LLKSLSAERE RWEKTSETFK NQMSTIAGDC LLSAAFIAYA GYFDQQMRQN LFTTWSHHLQ
     QANIQFRTDI ARTEYLSNAD ERLRWQASSL PADDLCTENA IMLKRFNRYP LIIDPSGQAT
     EFIMNEYKDR KITRTSFLDD AFRKNLESAL RFGNPLLVQD VESYDPVLNP VLNREVRRTG
     GRVLITLGDQ DIDLSPSFVI FLSTRDPTVE FPPDLCSRVT FVNFTVTRSS LQSQCDLTCV
     PELHPCRPYF HRRL
//