ID A0A2K5ZXC9_MANLE Unreviewed; 4546 AA.
AC A0A2K5ZXC9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=LDL receptor related protein 1 {ECO:0000313|Ensembl:ENSMLEP00000032442.1};
GN Name=LRP1 {ECO:0000313|Ensembl:ENSMLEP00000032442.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000032442.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000032442.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9568.ENSMLEP00000032442; -.
DR Ensembl; ENSMLET00000056019.1; ENSMLEP00000032442.1; ENSMLEG00000039373.1.
DR GeneTree; ENSGT00940000157899; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0016964; F:alpha-2 macroglobulin receptor activity; IEA:Ensembl.
DR GO; GO:0034185; F:apolipoprotein binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0032050; F:clathrin heavy chain binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0150094; P:amyloid-beta clearance by cellular catabolic process; IEA:Ensembl.
DR GO; GO:0150093; P:amyloid-beta clearance by transcytosis; IEA:Ensembl.
DR GO; GO:0006909; P:phagocytosis; IEA:Ensembl.
DR GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
DR GO; GO:1905167; P:positive regulation of lysosomal protein catabolic process; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 30.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 29.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR032485; LRP1-like_beta_prop.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF16472; DUF5050; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 28.
DR Pfam; PF00058; Ldl_recept_b; 11.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 26.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00192; LDLa; 30.
DR SMART; SM00135; LY; 34.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 29.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 16.
DR PROSITE; PS50068; LDLRA_2; 30.
DR PROSITE; PS51120; LDLRB; 25.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..4546
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014457504"
FT TRANSMEM 4416..4436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 334..377
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 378..421
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 570..612
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 613..658
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 659..709
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 710..753
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1308..1354
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1355..1397
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1398..1444
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1445..1489
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1626..1668
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1669..1712
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1713..1752
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1933..1975
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1976..2018
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2019..2062
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2063..2106
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2343..2387
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2388..2430
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 2970..3005
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 3057..3101
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3102..3144
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3145..3188
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3189..3231
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3962..4004
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4005..4048
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4188..4221
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4224..4260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4261..4293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4296..4332
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4367..4401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 853..865
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 860..878
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 894..906
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 901..919
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 935..947
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 942..960
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 983..1001
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 995..1010
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1014..1026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1021..1039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1081..1096
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1124..1139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2531..2549
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2599..2617
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2611..2626
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2661..2676
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2684..2696
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2691..2709
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2703..2718
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2722..2734
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2729..2747
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2806..2818
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2813..2831
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2846..2858
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2900..2918
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2912..2927
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2974..2984
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3322..3334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3329..3347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3366..3378
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3373..3391
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3385..3400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3425..3440
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3528..3540
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3535..3553
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3547..3562
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3567..3579
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3574..3592
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3586..3601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3605..3617
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3612..3630
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3624..3639
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3646..3658
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3653..3671
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3708..3723
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3741..3759
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3753..3768
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4192..4202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4228..4238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4250..4259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4264..4274
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4300..4310
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4322..4331
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4369..4379
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4391..4400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4546 AA; 505087 MW; F61D97958B6A234C CRC64;
GDLRPWLSST LHLYPLSFLA LAPKTCSPKQ FACRDQITCI SKGWRCDGER DCPDGSDEAP
EICPQSKAQR CQPNEHNCLG TELCVPMSRL CNGVQDCMDG SDEGPHCREL RGNCSRLGCQ
HHCVPTLDGP TCYCNSSFQL QADSKTCKDF DECSVYGTCS QLCTNTDGSF ICGCVEGYLL
QPDNRSCKAK NEPVDRPPVL LIANSQNILA TYLSGAQVST ITPTSTRQTT AMDFSYANET
VCWVHVGDNA AQTQLKCARM PGLKGFVDEH TINISLSLHH VEQMAIDWLT GNFYFVDDID
DRIFVCNRNG DTCVTLLDLE LYNPKGIALD PAMGKVFFTD YGQIPKVERC DMDGQNRTKL
VDSKIVFPHG ITLDLVSRLV YWADAYLDYI EVVDYEGKGR QTIIQGILIE HLYGLTVFEN
YLYATNSDNA NAQQKTSVIR VNRFNSTEYQ VVTRVDKGGA LHIYHQRRQP RVRSHACEND
QYGKPGGCSD ICLLANSHKA RTCRCRSGFS LGSDGKSCKK PEHELFLVYG KGRPGIIRGM
DMGAKVPDEH MIPIENLMNP RALDFHAETG FIYFADTTSY LIGRQKIDGT ERETILKDGI
HNVEGVAVDW MGDNLYWTDD GPKKTISVAR LEKAAQTRKT LIEGKMTHPR AIVVDPLNGW
MYWTDWEEDP KDSRRGRLER AWMDGSHRDI FVTSKTVLWP NGLSLDIPAG RLYWVDAFYD
RIETILLNGT DRKIVYEGPE LNHAFGLCHH GNYLFWTEYR SGSVYRLERG VGGAPPTVTL
LRSERPPIFE IRMYDAQQQQ VGTNKCRVNN GGCSSLCLAT PGSRQCACAE DQVLDADGVT
CLANPSYVPP PQCQPGEFAC ANSRCIQERW KCDGDNDCLD NSDEAPALCH QHTCPSDRFK
CENNRCIPNR WLCDGDNDCG NSEDESNATC SARTCPPNQF SCASGRCIPI SWTCDLDDDC
GDRSDESASC AYPTCFPLTQ FTCNNGRCIN INWRCDNDND CGDNSDEAGC SHSCSSTQFK
CNSGRCIPEH WTCDGDNDCG DYSDETHANC TNQATRPPGG CHTDEFQCRL DGLCIPLRWR
CDGDTDCMDS SDEKSCEGVT HVCDPSVKFG CKDSARCISK AWVCDGDNDC EDNSDEENCE
SLACRPPSHP CANNTSVCLP PDKLCDGNDD CGDGSDEGEL CDQCSLNNGG CSHNCSVAPG
EGIVCSCPLG MELGPDNHTC QIQSYCAKHL KCSQKCDQNK FSVKCSCYEG WVLEPDGESC
RSLDPFKPFI IFSNRHEIRR IDLHKGDYSV LVPGLRNTIA LDFHLSQSAL YWTDVVEDKI
YRGKLLDNGA LTSFEVVIQY GLATPEGLAV DWIAGNIYWV ESNLDQIEVA KLDGTLRTTL
LAGDIEHPRA IALDPRDGIL FWTDWDASLP RIEAASMSGA GRRTVHRETG SGGWPNGLTV
DYLEKRILWI DARSDAIYSA RYDGSGHMEV LRGHEFLSHP FAVTLYGGEV YWTDWRTNTL
AKANKWTGHN VTVVQRTNTQ PFDLQVYHPS RQPMAPNPCE ANGGRGPCSH LCLINYNRTV
SCACPHLMKL HKDKTTCYEF KKFLLYARQM EIRGVDLDAP YYNYIISFTV PDIDNVTVLD
YDAREQRVYW SDVRTQAIKR AFINGTGVET VVSADLPNAH GLAVDWVSRN LFWTSYDTNK
KQINVARLDG SFKNAVVQGL EQPHGLVVHP LRGKLYWTDG DNISMANMDG SNRTLLFSGQ
KGPVGLAIDF PESKLYWISS GNHTINRCNL DGSGLEVIEA MRSQLGKATA LAIMGDKLWW
ADQVSEKMGT CSKADGSGSV VLRNSTTLVM HMKVYDESIQ LDHKGTNPCS VNNGDCSQLC
LPTSETTRSC MCTAGYSLRS GQQACEGVGS FLLYSVHEGI RGIPLDPNDK SDALVPVSGT
SLAVGIDFHA ENDTIYWVDM GLSTISRAKR DQTWREDVVT NGIGRVEGIA VDWIAGNIYW
TDQGFDVIEV ARLNGSFRYV VISQGLDKPR AITVHPEKGY LFWTEWGQYP RIERSRLDGT
ERVVLVNVSI SWPNGISVDY QDGKLYWCDA RTDKIERIDL ETGENREVVL SSNNMDMFSV
SVFEDFIYWS DRTHANGSIK RGSKDNATDS VPLRTGIGVQ LKDIKVFNRD RQKGTNVCAV
ANGGCQQLCL YRGRGQRACA CAHGMLAEDG ASCREYAGYL LYSERTILKS IHLSDERNLN
APVQPFEDPE HMKNVIALAF DYRAGTSPGT PNRIFFSDIH FGNIQQINDD GSRRITIVEN
VGSVEGLAYH RGWDTLYWTS YTTSTITRHT VDQTRPGAFE RETVITMSGD DHPRAFVLDE
CQNLMFWTNW NEQHPSIMRA ALSGANVLTL IEKDIRTPNG LAIDHRAEKL YFSDATLDKI
ERCEYDGSHR YVILKSEPVH PFGLAVYGEH IFWTDWVRRA VQRANKHVGS NMKLLRVDIP
QQPMGIIAVA NDTNSCELSP CRINNGGCQD LCLLTHQGHV NCSCRGGRIL QDDLTCRAVN
SSCRAQDEFE CANGECINFS LTCDGVPHCK DKSDEKPSYC TQVLLPQLMK GRTTVSLYWA
FGLGGGSPFP VPMKTFRQCS NGRCVSNMLW CNGADDCGDG SDEIPCNSAT DCSSYFRLGV
KGVLFQPCER TSLCYAPSWV CDGANDCGDY SDERDCPGVK RPRCPLNYFA CPSGRCIPMS
WTCDKEDDCE HGEDETHCNK FCSEAQFECQ NHRCISKQWL CDGSDDCGDG SDEAAHCEGK
TCGPSSFSCP GTHVCVPERW LCDGDKDCAD GADESIAAGC LYNSTCDDRE FMCQNRQCIP
KHFVCDHDRD CADGSDESPE CEYPTCGPSE FRCANGRCLS SRQWECDGEN DCHDQSDEAP
KNPHCTSPEH KCNASSQFLC SSGRCVAEVL LCNGQDDCGD GSDERGCHIN ECLSHKLSGC
SQDCEDLKIG FKCRCRPGFR LKDDGRTCAD VDECSTTFPC SQRCINTHGS YKCLCVEGYA
PRGGDPHSCK AVTDEEPFLI FANRYYLRKL NLDGSNYTLL KQGLNNAVAL DFDYREQMIY
WTDVTTQGSM IRRMHLNGSN VQVLHRTGLS NPDGLAVDWV GGNLYWCDKG RDTIEVSKLN
GAYRTVLVSS GLREPRALVV DVQNGYLYWT DWGDHSLIGR IGMDGSSRSV IVDTKITWPN
GLTLDYVTER IYWADAREDY IEFASLDGSN RHVVLSQDIP HIFALTLFED YVYWTDWETK
SINRAHKTTG TNKTLLISTL HRPMDLHVFH ALRQPDVPNH PCKVNNGGCS NLCLLSPGGG
HKCACPTNFY LGSDGRTCVS NCTASQFVCK NDKCIPFWWK CDTEDDCGDH SDEPPDWCPA
VSEFKCRPGQ FQCSTGICTN PAFICDGDND CQDNSDEANC DIHVCLPSQF KCTNTNRCIP
GIFRCNGQDN CGDGEDERDC PEVTCAPNQF QCSITKRCIP RVWVCDRDND CVDGSDEPAN
CTQMTCGVDE FRCKDSGRCI PARWKCDGED DCGDGSDEPK EECDERTCEP YQFRCKNNRC
VPGRWQCDYD NDCGDNSDEE SCTPRPCSES EFSCANGRCI AGRWKCDGDH DCADGSDEKD
CTPRCDMDQF QCKSGHCIPL RWRCDADADC MDGSDEEACG TGVRTCPLDE FQCNNTLCKP
LAWKCDGEDD CGDNSDENPE ECARFVCPPN RPFRCKNDRV CLWIGRQCDG MDNCGDGTDE
EDCEPPTAQT THCKDKKEFL CRNQRCLSSS LRCNMFDDCG DGSDEEDCSI DPKLTSCATN
ASICGDEARC VRTEKAAYCA CRSGFHTVPG QPGCQDINEC LRFGTCSQLC NNTKGGHLCS
CARNFMKTHN TCKAEGSEYQ VLYIADDNEI RSLFPGHPHS AYEQAFQGDE SVRIDAMDVH
VKAGRVYWTN WHTGTISYRS LPPAAPPTTS NRHRRQIDRG VTHLNISGLK MPRGIAIDWV
AGNVYWTDSG RDVIEVAQMK GENRKTLISG MIDEPHAIVV DPLRGTMYWS DWGNHPKIET
AAMDGTLRET LVQDNIQWPT GLAVDYHNER LYWADAKLSV IGSIRLNGTD PIVAADSKRG
LSHPFSIDVF EDYIYGVTYI NNRVFKIHKF GHSPLVNLTG GLSHASDVVL YHQHKQPEVT
NPCDRKKCEW LCLLSPSGPV CTCPNGKRLD NGTCVPVPSP TPPPDAPRPG TCNLQCFNGG
SCFLNARRQP KCRCQPRYTG DKCELDQCWE HCRNGGTCAA SPSGMPTCRC PTGFTGPKCT
QQVCAGYCAN NSTCTVNQGN QPQCRCLPGF LGDRCQYRQC SGYCENFGTC QMAADGSRQC
RCTAYFEGLR CEVNKCSRCL EGACVVNKQS GDVTCNCTDG RVAPSCLTCI GHCSNGGSCT
MNSKMMPECQ CPPHMTGPRC EEHVFSQQQP GHIASILIPL LLLLLVLLVA GVVFWYKRRV
QGAKGFQHQR MTNGAMNVEI GNPTYKMYEG GEPDDAVGGL TKGRWGWGDL AIPEPSVTLQ
PTNFTNPVYA TLYMGGHGSR HSLASTDEKR ELLGRGPEDE IGDPLA
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