ID A0A2K5ZYH2_MANLE Unreviewed; 1082 AA.
AC A0A2K5ZYH2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Integrin subunit alpha D {ECO:0000313|Ensembl:ENSMLEP00000032848.1};
GN Name=ITGAD {ECO:0000313|Ensembl:ENSMLEP00000032848.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000032848.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000032848.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A2K5ZYH2; -.
DR STRING; 9568.ENSMLEP00000032848; -.
DR Ensembl; ENSMLET00000056426.1; ENSMLEP00000032848.1; ENSMLEG00000040618.1.
DR GeneTree; ENSGT00940000160953; -.
DR OMA; EHRYHVN; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034113; P:heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF132; INTEGRIN ALPHA-D; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 3.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 18..1082
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5014209633"
FT TRANSMEM 1021..1044
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 19..76
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 150..328
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 339..390
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 427..485
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 490..550
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1082 AA; 118333 MW; 943FA5ADEE94FA0B CRC64;
MTFGTVLLLS VLASFHGFNL DVEEPTIFQE DAGGFGQSVV QFGGSRLVVA APLEVVAANQ
TGRLYDCTAA TGVCQSIPLH IHPEAVNMSL GLTLAASTNR SWLLACGPTL HRVCGENSYS
KGSCLLLGSH WEIIQTVPDA LPECPHQEMD IVFLIDGSGS INQNDFNQMK GFVQAVMDQF
AGTDTLFALM QYSNFPKIHF TFTQFRTSRS QQSLVDPIVQ LKGQTFTATG ILQVVTQLFH
HKNGARKSAK KILIVITDGQ KYKDPLEYRD VIPQAEKAGI IRYAIGVGRA FQKPTARQEL
NTIGSAPPQD HVFKVDNFAA LSSIQKQLQE KIYAVEGTQS RASSSFQHEM SQEGFSAALT
MDGLVLGAVG SFSWSGGAFL YSPNMSPIFI NMSQENVDMR DSYLEQTRGG QVSVCPLPRG
RVQWQCEAVL CGEQSHPWGR FGAALTVLGD VNGDKLSDVA IGAPGEQENR GAVYLFHGAS
ESSISPSHSQ RIAGSQLSPR LQYFGQALSG GQDLTQDGLM DLAVGARGQV LLLRSLPVLK
VGVTMRFSPG EVAKSVYWCW EEGPSALEAG DATICLTIQK SSLDQLGDVQ SSVRFDLALD
PGRLTSRAIF DETKNPTLTR RKTLGLGVHC EILKLLLKDC VEDVVSPIIL HLNFSLVREP
IPSPQNLRPV LAMGSQDLFT ASLPFEKNCG QDGLCEGDLG VTLSFSGLKI LIVGSSLELN
VIVTVWNAGE DSYGTVVSLY YPAGLSHRRV LGAQKQPHQR ALRLACETVP TEDEGLRSSR
CSVNHPIFRE GSNGTFIVTF DVSYKATLGD RMLMRASASS ENNKASGSKA TFQLELPVKY
AVHTVISRQE ESTKYFNFTT SDEKKMKEAE HRYRVNNLSQ RDLSISITFW VPVLLNGVAV
WDVVVEAPSQ SLPCVSERKP PQHSDFLTQI SRSPVLDCSI AGCLRFRCDI PSFSVQEELD
FTLKGNLSFG WVRQTSQKKV SVVSVAEITF DTSVYSQLPG QEAFMRAQME MVLEEYEVYN
AIPIIMGSSV GALLLLALIT AALYKLGFFK RHYKEMLEDK LEETATFSGE DFSCGAPNVP
LS
//