ID A0A2K5ZZ48_MANLE Unreviewed; 518 AA.
AC A0A2K5ZZ48;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ankyrin repeat and SOCS box containing 3 {ECO:0000313|Ensembl:ENSMLEP00000033079.1};
GN Name=ASB3 {ECO:0000313|Ensembl:ENSMLEP00000033079.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000033079.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000033079.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
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DR RefSeq; XP_011822470.1; XM_011967080.1.
DR RefSeq; XP_011822471.1; XM_011967081.1.
DR AlphaFoldDB; A0A2K5ZZ48; -.
DR Ensembl; ENSMLET00000056659.1; ENSMLEP00000033079.1; ENSMLEG00000040731.1.
DR GeneID; 105529839; -.
DR CTD; 51130; -.
DR GeneTree; ENSGT00940000159080; -.
DR OMA; DCRSPMC; -.
DR OrthoDB; 662654at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03722; SOCS_ASB3; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037329; ASB3_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT REPEAT 9..41
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 145..177
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 178..210
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 211..243
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 441..504
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 518 AA; 57832 MW; 7525FCA62C03D943 CRC64;
MDFTEAYADT CSTVGLAARE GNVKVLRKLL KKGRSVDVAD NRGWMPIHEA AYHNSVECLQ
MLINADSSEN YIKMKTFEGF CALHLAASQG HWKIVQILLE AGADPNATTL EETTPLFLAV
ENGQIDVLKL LLQHGANVNG SHSMCGWNSL HQASFQENAE IIKLLLKKGA NKECQDDFGI
TPLFVAAQYG KLESLSILIS SGANVNCQAL DKATPLFIAA QEGHTKCVEL LLSSGADPDL
YCNEDNWQLP IHAAAQMGHT KILDLLIPLT NRACDTELNK VSPVYSAVFG GHEDCLEILL
RNGYSPDAQA CLVFGFSSPV CMAFQKDCEF FGIVNILLKY GARINELHLA YCLKYEKFSI
FRYFLRKGCS LGPWNHIYEF VNHAVKAQAK YKEWLPHLLV AGFDPQVLLC NSWIDSVSID
TLTFTLEFTN WKTLPPAVER MLSARASNAW ILQQHIATIP SLTHLCRLEI RSSLKSERLR
SDSYISELPL PRSLHNYLLY EDVLRMYEVP ELAAIQDG
//
