ID   A0A2K6A1C2_MANLE        Unreviewed;       944 AA.
AC   A0A2K6A1C2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Sorting nexin 13 {ECO:0000313|Ensembl:ENSMLEP00000033852.1};
GN   Name=SNX13 {ECO:0000313|Ensembl:ENSMLEP00000033852.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000033852.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000033852.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   AlphaFoldDB; A0A2K6A1C2; -.
DR   Ensembl; ENSMLET00000057437.1; ENSMLEP00000033852.1; ENSMLEG00000041046.1.
DR   GeneTree; ENSGT00950000182856; -.
DR   OMA; EWTPTNV; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06873; PX_SNX13; 1.
DR   CDD; cd08719; RGS_SNX13; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037437; SNX13_PX.
DR   InterPro; IPR037896; SNX13_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          92..279
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          368..491
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          546..667
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          519..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..533
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   944 AA;  109709 MW;  33DF638AEF50EE70 CRC64;
     ILSIWGWGSL GIVLFLITFG PFVIFYSTFY ILCFVGGGLV VTLLFGKTNS EKYLEQCEHS
     FLPPTSTGVP KCLEEMKREA RTIKIDRRLT GANIIDEPLQ QVIQFSLRDY VQYWYYTLSD
     DESFLLEIRQ TLQNALIQFA TRSKEIDWQP YFTTRIVDDF GTHLRVFRKA QQKITEKDDQ
     VKGTAEDLVD TFFEVEVEME KEVCRDLVCT SPKDEEGFLR DLCEVLLYLL LPPGDFQNKI
     MRYFVREILA RGILLPLINQ LSDPDYINQY VIWMIRDSNC NYEAFMNIIK LSDNIGELEA
     VRDKAAEELQ YLRSLDTAGD DINTIKNQIN SLLFVKKVCD SRIQRLQSGK EINTVKLAAN
     FGKLCTVPLD SILVDNVALQ FFMDYMQQTG GQAHLFFWMT VEGYRVTAQQ QLEVLLSRQR
     DGKHQTNQTK GLLRAAAVGI YEQYLSEKAS PRVTVDDYLV AKLADTLNHE DPTPEIFDDI
     QRKVYELMLR DERFYPSFRQ NALYVRMLAE LDMLKDPSFR GSDDGDGDKS PLSHDDLSNV
     SSDDSVQLHA YISDTGVCND HGKTYALYAI TVHRRNLNSE EMWKTYRRYS DFHDFHMRIT
     EQFESLSSIL KLPGKKTFNN MDRDFLEKRK KDLNAYLQLL LAPEMMKASP ALAHYVYDFL
     ENKAYSKGKG DFARKMDTFV NPLRNSMRNV SNAVKSLPDS LAEGMTKMSD NMGKMSERLG
     QDIKQSFFKV PPLIPKTDSD PEHRRVSAQL DDNVDDNIPL RVMLLLMDEV FDLKERNQWL
     RRNIKNLLQQ LIRATYGDTI NRKIVDHVDW MTSPEQVADS VKRFRDAFWP NGILAETVPC
     RDKSIRMRTR VAGKTKLLAI MPDELKHIIG AETTRKGILR VFEMFQHNQL NRRMVYVFLE
     GFLETLFPQY KFRELFNKLH SRSKQMQKYK QKLQTTQAPS LQKR
//