ID A0A2K6A2J7_MANLE Unreviewed; 744 AA.
AC A0A2K6A2J7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Semaphorin 3E {ECO:0000313|Ensembl:ENSMLEP00000034290.1};
GN Name=SEMA3E {ECO:0000313|Ensembl:ENSMLEP00000034290.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000034290.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000034290.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A2K6A2J7; -.
DR STRING; 9568.ENSMLEP00000034290; -.
DR Ensembl; ENSMLET00000057877.1; ENSMLEP00000034290.1; ENSMLEG00000041316.1.
DR GeneTree; ENSGT00940000158437; -.
DR OMA; ASECANF; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0048018; F:receptor ligand activity; IEA:Ensembl.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:Ensembl.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0021828; P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR CDD; cd05871; Ig_Sema3; 1.
DR CDD; cd11253; Sema_3E; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015513; Semaphorin_3E_Sema.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF22; SEMAPHORIN-3E; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 32..516
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 563..638
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 710..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 86008 MW; EC636C923F9EF69C CRC64;
YVYQLLSFTL PLSPYIKNIN THTHTHTHTH THDLLPLLNL NRTSVFHSPF GFLDLHTMLL
DEYQERLFVG GRDLVYSLSL ERISDGYKEI HWPSTALKME ECIMKGKDAG ECANYVRVLH
HYNRTHLLTC GTGAFDPVCA FIRVGYHLED PLFHLESPRS ERGRGRCPFD PSSSFISTLI
GSELFAGLYS DYWSRDAAIF RSMGRLAHIR TEHDDERLLK EPKFVGSYMI PDNEDRDDNK
VYFFFTEKAL EAENNAHAIY TRVGRLCAND VGGQRILVNK WSTFLKARLV CSVPGMNGID
THFDELEDIF LLPTRDHKNP VIFGLFNTTS NIFRGHAICV YHMSSIRAAF NGPYAHKEGP
EYHWSVYEGK VPYPRPGSCA SNVNGGRYGT TKDYPDDAIR FARSHPLMYQ AIKPAHKKPI
LVKTDGKYNL KQIAVDRVEA EDGQYDVLFI GTDNGIVLKV ITIYNQEMES MEEVILEELQ
IFKDPVPIIS MEISSKRVSC LCVYVCERYD TKCSATCSIN REIYMRFRRQ DVRHGNAAQQ
CFGQQFVGDA LDKTEEHLAY GIENNSTLLE CTPRSLQAKV IWFVQKGRET RKEEVKTNDR
VVKMDLGLLF LRLHKSDAGT YFCQTVEHSF VHTVRKITLE VVEEEKVDDM FNKDDEEDKH
HRMPCPAQSS VSQGAKPWYK EFLQLIGYSN FQRVEEYCEK VWCTDRKRKK LKMSPSKWKY
ANPQEKKLRS KPEHYRLPRH TLDS
//
