ID A0A2K6A394_MANLE Unreviewed; 600 AA.
AC A0A2K6A394;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=FMR1 autosomal homolog 1 {ECO:0000313|Ensembl:ENSMLEP00000034517.1};
GN Name=FXR1 {ECO:0000313|Ensembl:ENSMLEP00000034517.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000034517.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000034517.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule
CC {ECO:0000256|ARBA:ARBA00004331}. Postsynapse
CC {ECO:0000256|ARBA:ARBA00034110}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
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DR AlphaFoldDB; A0A2K6A394; -.
DR Ensembl; ENSMLET00000058105.1; ENSMLEP00000034517.1; ENSMLEG00000041270.1.
DR GeneTree; ENSGT00950000183189; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:UniProtKB-SubCell.
DR GO; GO:0098794; C:postsynapse; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:InterPro.
DR CDD; cd22504; KH_I_FXR1_rpt1; 1.
DR CDD; cd22507; KH_I_FXR1_rpt2; 1.
DR CDD; cd22510; KH_I_FXR1_rpt3; 1.
DR CDD; cd20475; Tudor_Agenet_FXR1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR032172; FXR1_C1.
DR InterPro; IPR032177; FXR_C3.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047494; KH_I_FXR1_rpt1.
DR InterPro; IPR047495; KH_I_FXR1_rpt2.
DR InterPro; IPR047496; KH_I_FXR1_rpt3.
DR InterPro; IPR047427; Tudor_Agenet_FXR1_rpt2.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF6; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN 1; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF12235; FXMRP1_C_core; 2.
DR Pfam; PF16096; FXR_C1; 1.
DR Pfam; PF16097; FXR_C3; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF17904; KH_9; 1.
DR Pfam; PF18336; Tudor_FRX1; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 2.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 1..34
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT DOMAIN 47..99
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 383..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 67609 MW; 4741373406A9BC9F CRC64;
QGFIKDVHED SLTVVFENNW QPERQVPFNE VRLPPPPDIK KEISEGDEVE VYSRANDQEP
CGWWLAKVRM MKGEFYVIEY AACDATYNEI VTFERLRPVN QNKTVKKNTF FKCTVDVPED
LREACANENA HKDFKKAVGA CRIFYHPETT QLMILSASEA TVKRVNILSD MHLRSIRTKL
MLMSRNEEAT KHLECTKQLA AAFHEEFVVR EDLMGLAIGT HGSNIQQARK VPGVTAIELD
EDTGTFRIYG ESADAVKKAR GFLEFVEDFI QVPRNLVGKV IGKNGKVIQE IVDKSGVVRV
RIEGDNENKL PREDGMVPFV FVGTKESIGN VQVLLEYHIA YLKEVEQLRM ERLQIDEQLR
QIASFYRNLI GLYSFLLQGT NSELSNPSET ESERKDELSD WSLAGEDDRD SRHQRDSRRR
PGGRGRSVSG GRGRGGPRGG KSSISSVLKD PDSNPYSLLD NTESDQTADT DASESHHSTN
RRRRSRRRRT DEDAVLMDGM TESDTASVNE NGLVTVADYI SRAESQSRQR NLPRETLAKN
KKEMAKDVIE EHGPSEKAIN GPTSASGDDI SKLQRTPGEE KINTLKEENT QEAAVLNGVS
//
