ID   A0A2K6A4C8_MANLE        Unreviewed;       692 AA.
AC   A0A2K6A4C8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=EPS8 like 2 {ECO:0000313|Ensembl:ENSMLEP00000034919.1};
GN   Name=EPS8L2 {ECO:0000313|Ensembl:ENSMLEP00000034919.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000034919.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000034919.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the EPS8 family.
CC       {ECO:0000256|ARBA:ARBA00006197}.
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DR   AlphaFoldDB; A0A2K6A4C8; -.
DR   STRING; 9568.ENSMLEP00000034919; -.
DR   Ensembl; ENSMLET00000058512.1; ENSMLEP00000034919.1; ENSMLEG00000041593.1.
DR   GeneTree; ENSGT00940000160990; -.
DR   OMA; RNTMALY; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
DR   GO; GO:0032426; C:stereocilium tip; IEA:Ensembl.
DR   GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR   GO; GO:1900029; P:positive regulation of ruffle assembly; IEA:Ensembl.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:Ensembl.
DR   GO; GO:0007266; P:Rho protein signal transduction; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   CDD; cd01210; PTB_EPS8; 1.
DR   CDD; cd09540; SAM_EPS8-like; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR039801; EPS8-like.
DR   InterPro; IPR033928; EPS8_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR013625; PTB.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041418; SAM_3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12287:SF20; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2; 1.
DR   PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR   Pfam; PF08416; PTB; 1.
DR   Pfam; PF18016; SAM_3; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT   DOMAIN          47..197
FT                   /note="PID"
FT                   /evidence="ECO:0000259|SMART:SM00462"
FT   REGION          195..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..480
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   692 AA;  77781 MW;  267DA765088B5EF8 CRC64;
     MSQSGAVSCC PGATNGSLGR SDSVARMSPK DLFEQRKKYS NSNVIMHETS QYHVQHLATF
     IMDKSEAITS VEDAIRKLVQ LSSKEKIWTQ EMLLQVNDQS LRLLDIESQV GGACAPGVST
     VPEELENFPL PTVQRSQTVL NQLRYPSVLL LVCQDSEQSK PDVHFFHCDE VEAELVHEDI
     ESALADCRLG KKMRPQTLKG HQEKIRQRQS ILPPPQGPAP IPFQHRSGDS PQAKNRVGPQ
     VPLSEPGFRR RESQEEEPRA VLAQKIEKET QILNCALDDI EWFVARLQKA AEAFKQLNQR
     KKGKKKGKKG PAEGVLTLRA RPPSEGEFVD CFQKIKLAIN LLAKLQKHIQ NPSAAELVHF
     LFGPLDLIVN TCGGPDIARS VSCPLLSQDA VDFLRGHLVP KEMSLWESLG ESWMRPRSEW
     PREPQVPLYV PKFHSGWEPP VDVLQEAPWE VEGLASAPIE VSPVSRQSVR NSQKHSPASE
     PTPTGDALPP VSSPHTHRGY QPTPAMAKYV KILYDFTARN ANELSVLKDE VLEVLEDGRQ
     WWKLPTHKLP PSFPGNKDGE SCCFQHMDEV NDELIRKISN IRAQPQRHFR VERSQPVSQP
     LTYESGPDEV RAWLEAKAFS ARIVENLGIL TGPQLFSLNK EELKKVCGEE GVRVYSQLTV
     QKAFLEKQQS GSELEELMNK FHSMNQRRGE DS
//