ID A0A2K6A4T8_MANLE Unreviewed; 400 AA.
AC A0A2K6A4T8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Pleckstrin homology domain-containing family O member 1 {ECO:0000256|ARBA:ARBA00019333};
GN Name=PLEKHO1 {ECO:0000313|Ensembl:ENSMLEP00000035084.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000035084.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000035084.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K6A4T8; -.
DR Ensembl; ENSMLET00000058679.1; ENSMLEP00000035084.1; ENSMLEG00000041687.1.
DR GeneTree; ENSGT00530000063760; -.
DR OMA; VQPEKVG; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0036195; C:muscle cell projection membrane; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
DR GO; GO:0072673; P:lamellipodium morphogenesis; IEA:Ensembl.
DR GO; GO:0007520; P:myoblast fusion; IEA:Ensembl.
DR GO; GO:0051451; P:myoblast migration; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR CDD; cd13317; PH_PLEKHO1_PLEKHO2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043448; PKHO1/2.
DR PANTHER; PTHR15871; PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15871:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY O MEMBER 1; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 12..123
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 209..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 45123 MW; 05AD0C80F5D1B464 CRC64;
QGPQDGNQQP APPEKVGWVR KFCGKGIFRE IWKNRYVVLK GDQLYISEKE VKDEKNIQEV
FDLSDYEKCE ELRKSKSRSK KNHSKFTLAH SKQPGNTAPN LIFLAVSPEE KESWISALNS
AITRAKNRIL DEVTVEEDSY LAHPTRDRAK IQHSRRPPTR GHLMAVASTS TSDGMLTLDL
IQEEDPSPEE PTSCAESFRV DLDKSVAQLA GSRRRADSDR IQPSADRASS LSRPWEKPDK
GATYTPQAPK KLTPTEKGRC ASLEEILSQR DAAPARTLQL QAEEPPSPAP PNPGQLSRIQ
DLVARKLEKT QELLAEVQGL GDGKRKAKDP PRSPPDSESE QLLLETERLL GEASSNWNQA
KRVLQEVREL RDLYRQMDLQ TPDSHLRQTT PHSQYRKSLM
//
