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Database: UniProt
Entry: A0A2K6A622_MANLE
LinkDB: A0A2K6A622_MANLE
Original site: A0A2K6A622_MANLE 
ID   A0A2K6A622_MANLE        Unreviewed;       790 AA.
AC   A0A2K6A622;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Solute carrier family 26 member 9 {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Anion transporter/exchanger protein 9 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A9 {ECO:0000313|Ensembl:ENSMLEP00000035520.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000035520.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000035520.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Ion transporter that can act both as an ion channel and anion
CC       exchanger. Mainly acts as a chloride channel, which mediate uncoupled
CC       chloride anion transport in an alternate-access mechanism where a
CC       saturable binding site is alternately exposed to either one or the
CC       other side of the membrane. Also acts as a DIDS- and
CC       thiosulfate- sensitive anion exchanger the exchange of chloride for
CC       bicarbonate ions across the cell membrane.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR   RefSeq; XP_011845782.1; XM_011990392.1.
DR   AlphaFoldDB; A0A2K6A622; -.
DR   STRING; 9568.ENSMLEP00000035520; -.
DR   Ensembl; ENSMLET00000059119.1; ENSMLEP00000035520.1; ENSMLEG00000041895.1.
DR   GeneID; 105547029; -.
DR   KEGG; mleu:105547029; -.
DR   CTD; 115019; -.
DR   GeneTree; ENSGT01100000263544; -.
DR   OMA; WKDMMGT; -.
DR   OrthoDB; 1067648at2759; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0005254; F:chloride channel activity; IEA:Ensembl.
DR   GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF17; SOLUTE CARRIER FAMILY 26 MEMBER 9; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        90..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        174..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        211..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        252..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        337..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        376..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        409..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        465..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          519..736
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          627..651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   790 AA;  86778 MW;  86356CE00DAF71FF CRC64;
     MSQPRPRYVV DRAAYSLTLF DDEFEKKDRT YPVGEKLRNT FRCSSAKIKA VVFGLLPVLS
     WLPKYKIKDY IVPDLLGGLS GGSIQVPQGM AFALLANLPA VNGLYSSFFP LLTYFFLGGV
     HQMVPGTFAV ISILVGNICL QLAPESKFQV FNNATNESYV DTAAMEAERL HVSATLACLT
     AIIQIGLGFM QFGFVAIYLS ESFIRGFMTA AGLQILISVL KYIFGLTIPS YAGPGSIVFT
     FIDICKNLPH TNIASLIFAL ISGVFLVLVK ELNARYMHKI RFPIPTEMIV VVVATAISGG
     CKMPKKYHMQ IVGEIQRGFP TPVSPVVSQW KDMIGTAFSL AIVGYVINLA MGRTLANKHG
     YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA GGKSQVASLC VSLVVMITML
     VLGTYLYPLP KSVLGALIAV NLKNSLKQLT DPYYLWRKSK LDCCIWVVSF LSSFFLSLPY
     GVAVGVAFSV LVVVFQTQFR NGYALAQVMD TDIYVNPKTY SRAQDIQGIK IITYCSPLYF
     ANSEIFRQKV IAKTGMDPQK VLLAKQKYLK KQKRRMRPTQ QRRSLFMKTK TVSLQELQQD
     FENASPTDPN NNQTQANGTS VSYITFSPDS SSAAQSEPPA SAEAPGEPSD TLASVPPFVT
     FHTLILDMSG VSFVDLMGIK TLAKLSSTYG KIGVKVFLVN IHAQVYNDIS HGGVFEDGSL
     ECKHVFPSIH DAVLFAQANA RDVTPGHNFQ GAPGDPELSL YDSEEDIPSY WDLEQEMFGS
     MFHTETLTAL
//
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