ID A0A2K6A622_MANLE Unreviewed; 790 AA.
AC A0A2K6A622;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Solute carrier family 26 member 9 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Anion transporter/exchanger protein 9 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A9 {ECO:0000313|Ensembl:ENSMLEP00000035520.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000035520.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000035520.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Ion transporter that can act both as an ion channel and anion
CC exchanger. Mainly acts as a chloride channel, which mediate uncoupled
CC chloride anion transport in an alternate-access mechanism where a
CC saturable binding site is alternately exposed to either one or the
CC other side of the membrane. Also acts as a DIDS- and
CC thiosulfate- sensitive anion exchanger the exchange of chloride for
CC bicarbonate ions across the cell membrane.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_011845782.1; XM_011990392.1.
DR AlphaFoldDB; A0A2K6A622; -.
DR STRING; 9568.ENSMLEP00000035520; -.
DR Ensembl; ENSMLET00000059119.1; ENSMLEP00000035520.1; ENSMLEG00000041895.1.
DR GeneID; 105547029; -.
DR KEGG; mleu:105547029; -.
DR CTD; 115019; -.
DR GeneTree; ENSGT01100000263544; -.
DR OMA; WKDMMGT; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0005254; F:chloride channel activity; IEA:Ensembl.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF17; SOLUTE CARRIER FAMILY 26 MEMBER 9; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 90..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 174..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 211..232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 252..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 376..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 409..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 465..495
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 519..736
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 627..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 86778 MW; 86356CE00DAF71FF CRC64;
MSQPRPRYVV DRAAYSLTLF DDEFEKKDRT YPVGEKLRNT FRCSSAKIKA VVFGLLPVLS
WLPKYKIKDY IVPDLLGGLS GGSIQVPQGM AFALLANLPA VNGLYSSFFP LLTYFFLGGV
HQMVPGTFAV ISILVGNICL QLAPESKFQV FNNATNESYV DTAAMEAERL HVSATLACLT
AIIQIGLGFM QFGFVAIYLS ESFIRGFMTA AGLQILISVL KYIFGLTIPS YAGPGSIVFT
FIDICKNLPH TNIASLIFAL ISGVFLVLVK ELNARYMHKI RFPIPTEMIV VVVATAISGG
CKMPKKYHMQ IVGEIQRGFP TPVSPVVSQW KDMIGTAFSL AIVGYVINLA MGRTLANKHG
YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA GGKSQVASLC VSLVVMITML
VLGTYLYPLP KSVLGALIAV NLKNSLKQLT DPYYLWRKSK LDCCIWVVSF LSSFFLSLPY
GVAVGVAFSV LVVVFQTQFR NGYALAQVMD TDIYVNPKTY SRAQDIQGIK IITYCSPLYF
ANSEIFRQKV IAKTGMDPQK VLLAKQKYLK KQKRRMRPTQ QRRSLFMKTK TVSLQELQQD
FENASPTDPN NNQTQANGTS VSYITFSPDS SSAAQSEPPA SAEAPGEPSD TLASVPPFVT
FHTLILDMSG VSFVDLMGIK TLAKLSSTYG KIGVKVFLVN IHAQVYNDIS HGGVFEDGSL
ECKHVFPSIH DAVLFAQANA RDVTPGHNFQ GAPGDPELSL YDSEEDIPSY WDLEQEMFGS
MFHTETLTAL
//