ID   A0A2K6A712_MANLE        Unreviewed;      1837 AA.
AC   A0A2K6A712;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=NLR family CARD domain containing 5 {ECO:0000313|Ensembl:ENSMLEP00000035798.1};
GN   Name=NLRC5 {ECO:0000313|Ensembl:ENSMLEP00000035798.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000035798.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000035798.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSMLET00000059397.1; ENSMLEP00000035798.1; ENSMLEG00000041990.1.
DR   GeneTree; ENSGT00940000160652; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.533.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 8.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041210; NLRC5_atypical_Card.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF281; PROTEIN NLRC5; 1.
DR   Pfam; PF18461; Atypical_Card; 1.
DR   Pfam; PF13516; LRR_6; 4.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   SMART; SM00367; LRR_CC; 10.
DR   SMART; SM00368; LRR_RI; 18.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 4.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          222..349
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          112..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1837 AA;  201725 MW;  E5ACF98B84B58DE3 CRC64;
     MDPVDLQLGN KNLWSCLVRL LSKDPEWLNA KMKFFLPNTD LDSRNETLDP EQRVILQLNK
     LHVQGSATWQ SFIHCVCMQL EVPLELEVLL LSTFGCDDGF TSQLGAEGKS LPQSQLHQGL
     KRPHQSCGSS PRRKQCRKQQ LELAKKYLQL LRTSAQQRYG SRIPGSGQPH AFHQVYVPPI
     LRRATASLDT QEGAIMGDLK VEDGTDVSIS DLFNTRVNKG PRVTVLLGKA GMGKTTLAHR
     LCQKWAEGHL DCFQALFLFE FRQLNLITRF LTLSQLLFDL YLSPESDPDA VFQYLEKNAD
     QVLLIFDGLD EALQPMGPDG PGSVLTLFSR LCRGTLLPGC RVMATSRPGK LPACLPAEAA
     MVYMLGFDGP RVEEYVNHFF SAQPLQEGAL AELQTNGRLR SLCAVPALCQ VACLCLHHLL
     PDHAPGQSVA LLPTMTQLYM QMVLALSPRG HLPTTSLLDL GEVALRGLET GKVIFYAKDI
     APPLIAFGAT HSLLTSFCVR TGPGHQQTGY AFTHVSLQEF LAALHLMASP KVDKDTLTQH
     VTLHSRWVQR TKARLDLSDH LPTFLAGLAS CTCRPFLSHL AQGNEDCVGT KQAAVVQVLK
     KLATRKLTGP KVVELCHCVN ETQEPELASL TAQSLPYQLP FHNFPLTCTD LATLTNILEH
     REAPIHLDFD GCPLEPHCPE ALVGCGQIEN LSFKSRKCGD AFAEALSRSL PTMGRLQMLG
     LAGSKITARG ISHLVKALPL CPQLEEVSFR DNQLSDQVVL HIVEVLPHLP RLRKLDLSGN
     SVCVSTLLCL ARVAVTCPTI RTLQARKADL IFLLSPPTET TAELQRAPDL QESDGQRKGA
     QSRSLTLRLQ KCQLQVHDAE TLIALLQEGP HLEEVDLSGN QLEDEGCRLM AEAASQLHIT
     RKLDLSDNGL SLAGVHCVLR AVSACWTLAE LHISLRHKTV VFMFAQEPEE QEGPQERAAF
     LDSLMLQMPS ELPLSSRRMR LTHCGLQAKH LEQLCKALGG SCHLGHLHLD FSGNALGDEG
     ATRLAQLLPG LGALQSLNLS ENGLSLDAVL DLARCFSTLQ WLFHLDISFE SQHILLRGDK
     TGRDIWTTGS SPDFPAGAEF LGFRRRCIPR SLRLSECPLE PPSLTHLCAT LKECPGPLEL
     QLSCEFLSDQ SLETLLDCLP RLPQLSLLQL SQTGLSPKSP FLLANTLSLC PRVKKVDLRS
     LHHATLHFRS NEEQEGVCCG LSANLLGDSG LRCLLECLPQ VPISGSLDLS HNSVSQESAL
     YLVETLPSCP RVREASVNLG SEQSFRIHFS KEDQAGKTLR LSECSFRPEH VSRLATGLSQ
     SLQLTELTLT QCCLDQEQLA ILLSLVGRPA GLFSLRVQEP WADRAGILSL LEVCAQASGS
     VTEISISKTQ QQLCVQLEFP RQEENPEAVA LRLTHCDLGT HHSLLVGQLM ETCARLQQLS
     LSQVNLCEDN DDSSLLLQNL LLSLSELKTF RLTSSCVSTE GLAHLASGLG HCHHLEELDL
     SNNQFDEEGT KALMRALEGK WMLKRLDLGH LLLNSSALTL LTHGLSHMTR LQSLRLKRNS
     IGDVGCCHLS EALRAATSLE ELDLSHNQIG DAGVLHLATI LPGLPELRKI DLSVNSISPA
     GGMQLAESLI LCRHLEELML GCNALGDPTA LGLARELPQH LRVLHLPFSH LGPGGALSLT
     QALDGSPHLE EISLAENNLA GGVLRFCKEL PLLRQIDLVS CKIDNQTVKL LTSSFTRCPA
     LEVILLSWNL LGDEAAAELA QVLPQMGRLK RVDLEKNQIT AFGAWLLAEG LAQGSSIQVI
     RLWNNPIPCD MAQRLKSQEP RLDFAFFDNQ SQAPWGT
//