ID A0A2K6A732_MANLE Unreviewed; 1902 AA.
AC A0A2K6A732;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=SET binding factor 1 {ECO:0000313|Ensembl:ENSMLEP00000035875.1};
GN Name=SBF1 {ECO:0000313|Ensembl:ENSMLEP00000035875.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000035875.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000035875.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR STRING; 9568.ENSMLEP00000035875; -.
DR Ensembl; ENSMLET00000059474.1; ENSMLEP00000035875.1; ENSMLEG00000041820.1.
DR GeneTree; ENSGT00940000155263; -.
DR OMA; FQHWEVV; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd13340; PH-GRAM_MTMR5; 1.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF43; MYOTUBULARIN-RELATED PROTEIN 5; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 13..453
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1129..1631
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1796..1900
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 96..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1640..1665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1717..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1758..1784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1097
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1902 AA; 211536 MW; E7FF875C6B137172 CRC64;
MASPHPDCDE LAAFLSPIYC PHPRSGEGQG QILQRFPEKD WEDNPFPQGI ELFCQPSGWQ
LCPERNPPTF FVAVLTDINS ERHYCACLTF WEPVEPSQET TREEDATERE EEEDEGGQTH
LSPTAPAPSA QLFAPKTLVL VSRLDHTEVF RNSLGLIYAI HVEGLNVCLE NVIGNLLTCT
VPLAGGSQLD SVEEGARTIS LGAGDRQVIQ TPLADSLPVS RCSVALLFRQ LGITNVLSLF
CAALTEHKVL FLSRSYQRLA DACRGLLALL FPLRYSFTYV PILPAQLLEV LSTPTPFIIG
VNAAFQAETQ ELLDVIVADL DGGTVAIPEC VHIPPLPEPL QSQTHSVLSM VLDPELELAD
LAFPPPTTST SSLKMQDKEL RAVFLRLFAQ LLQGYRWCLH VVRIHPEPVI RFHKVGHLVA
GGGVGDKCSL PGPAWAGAGG HGLSWGPVPP HRPLVAHEVA RMRADENHPQ RVLRHVQELA
EQLYKNENPY PAVAMHKVQR PGESSHLRRV PRPFPRLDEG TVQWIVDQAA AKMQGAPPAV
KAERRTTVPS GPPMTAILER CSGLHVNSAR RLEVVRNCIS YVFEGKMLEA KKLLPAVLRA
LKGRAARRCL AQELHLHVQQ NRAVLDHQQF DFVVRMMNCC LQDCTSLDEH GIAAALLPLV
TAFCRKLSPG VTQFAYSCVQ EHVVWSTPQF WEAMFYGDVQ THIRALYLEP TEDLAPAQEV
GEAPSQEDER SALDVASEQR RLWPTLSREK QQELVQKEES TVFSQAIHYA NRMSYLLLPL
DSSKSRLLRE RAGLGDLESA SNSLVTNSMA GSVAESYDTE SGFEDAETCD VAGAVVRFIN
RFVDKVCTES GVTSDHLKGL HVMVPDIVQM HIETLEAVQR ESRRLPPIQK PKLLRPRLLP
GEECVLDGLR VYLLPDGREE GAGGSAGGPA LLPAEGAVFL TTYRVIFTGM PTDPLVGEQV
VVRSFPVAAL TKEKRISVQT PVDQLLQDGL QLRSCTFQLL KMAFDEEVGS DSAELFRKQL
HKLRYPPDVR ATFAFTLGSA HTPGRPPRVT KDKGPSLRTL SRNLVKNAKK TIGRQHVTRK
KYNPPSWEHR GQPPPEDQED EISVSEELEP STLTPSSALK PSDRMTMSSL VERACCRDYQ
RLGLGTLSSS LSRAKSEPFR ISPVNRMYAI CRSYPGLLIV PQSVQDNALQ RVSRCYRQNR
FPVVCWRSGR SKAVLLRSGG LHGKGVVGLF KAQNAPSPGQ SQADSSSLEQ EKYLQAVVSS
MPRYADASGR NTLSGFSSAH MGSHVPSPRA RVTTLSNPMA ASASRRTAPR GKWGSVRTSG
RSSGLGTDVG SRLAGRDTLA PPQANGGPPD PGFLRPQRAA LYILGDKAQL KGVRPDPLQQ
WELVPIEVFE ARQVKASFKK LLKACVPGCP AAEPSPASFL RSLEDSEWLI QIHKLLQVSV
LVVELLDSGS SVLVGLEDGW DITTQVVSLV QLLSDPFYRT LEGFRLLLEK EWLSFGHRFS
HRGAHTLAGQ SSGFTPIFLQ FLDCVHQVHL QFPMEFEFSQ FYLKFLGYHH VSRRFRTFLL
DSDYERIELG LLYEEKGERR GQLPCRSVWE YVDRLSKRTP VFYNYMYAPE DTEVLRPYSN
VSNLKVWDFY TEETLAEGPP YDWELAQGPP EPPEEERSDG GAPQSRRRVV WPCYDSCPRA
QPDAISRLLE ELQRLETELG RPAERWKDTW DRVKAAQRLE GRPDGRGTPS SLLVSTAPHH
RRSLGVYLQE GPVGSTLSLS LDSDQSSGST ASGSRQAARR STSTLYSQFQ TAESENRSYE
GTLYKKGAFM KPWKARWFVL DKTKHQLRYY DHRVDTECKG VIDLAEVEAV APGTPTMGAP
KTVDEKAFFD VKTTRRVYNF CAQDVPSAQQ WVDRIQSCLS DA
//
