ID A0A2K6A7V3_MANLE Unreviewed; 1252 AA.
AC A0A2K6A7V3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSMLEP00000036141.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSMLEP00000036141.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000036141.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000036141.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR AlphaFoldDB; A0A2K6A7V3; -.
DR STRING; 9568.ENSMLEP00000036141; -.
DR Ensembl; ENSMLET00000059741.1; ENSMLEP00000036141.1; ENSMLEG00000042188.1.
DR GeneTree; ENSGT00940000154127; -.
DR OMA; IFFAQIK; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 246..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 407..434
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 651..678
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 951..985
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1022..1056
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1252 AA; 142072 MW; C4FA7E5F3B1FA97F CRC64;
GPGLRTPPGR SGVGPESSTQ DLPCMVWPKV ECCHFKTAVG APLGMKLYKK MEVFIPLSTS
AASSGPWAHS LFAFIPSWPK KNLFKRESPI THRLYGDISR EVQGTSENGV IFQKCALVSG
PSEAQTAHIW LLVNNTKTPS SANLSELLLL DSIAGLTVLE SIGNRTSEGF QAFSKKFLQV
GDAFAVSYAA TLQAGDLGNG ESLKLPAQLT FQSSSQNRTQ LKALFSITAE ENITVLPHHG
LHAAGFFIAF LLSLMLTWAA LFLMVHYQCL KGSMLTRHRV WQYDSKLEPL PFTSADGVNE
DLSLNDQMID ILSSEDPGSM LQALEELEIA TLNRADADLE ACRTQISKDI IALLLKNLTS
SGHLSPQVER KMSDVFKKQF MLLENEIQEE YDRKMVALTA ECDLETRKKM ENQYQREMMA
MEEAEELLKR ASERSAVECN SLLRTLHGLE QERLRKSLAL QQEEDFAKAH RQLAVFQRNE
LHRIFFTQIK SAILKGELKP EAAKTLLQNY SKIQENVEEL MDFFQASKRY HLSKRFGHRE
YLVQNLQSSE TRVQGLLSTA AAQLTHLIQK HERAGYLDED QMEMLLERAQ TEVFSIKQKL
DNDLKQEKKK LQQKLITKRR RELLQKHREQ RREQLSISEA FQAVEDAGQY LRQWRSLMEE
QGAALEELQE RLDQAALDDL RALTLSLFEK ATDELRRLQN SAMTQELLKR SVPWLFLQQI
LEEHSKEMAV RAEQLEGEER DRDQEGVQSV RQRLKDDAPE AATEEQAELR RWEHLVFMKL
CSSVFSLSEE ELLRMRQEVH GCFAQMDRSL ALPKIRARVL LQQFQTAWRE AEFLKLDQAL
AAPELQQQSK VRKSRSKSKS KGELLKKCIE DKIHLCEEQA SEDLVEKVRG ELLRERVQRL
EAQEGGFAQS LVALQFQKVA RITETLSAYT ALLSIQDLLL EELSASEMLT KSACTQILES
HSRELQELER KLEDQLVQQE AAQQQQALAS WQQWVADGPG ILSEPGEVDS ERQVSTVLQQ
ALSKSQTLLE QHQQSLREEQ QNSVVLEDLL ENMEADTFAT LCSQELRLAS YLARMAVVPG
ATLRRLLSVV LPTASQPQLL ALLDSGSERH PDHAAEGDGG GEQADVGRRR KHQSWWQAFD
SKLRGDLISR GLEKMLWARK RKQSVLKKSC LPLRERMIFS GKGSWPHLSL EPIGELAPVP
VVGAETIDVL NTGEKLFIFR NPKEPEISLH VPPRKKKNFL NAKKATRALG MD
//