ID A0A2K6A8B3_MANLE Unreviewed; 386 AA.
AC A0A2K6A8B3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Fli-1 proto-oncogene, ETS transcription factor {ECO:0000313|Ensembl:ENSMLEP00000036306.1};
GN Name=FLI1 {ECO:0000313|Ensembl:ENSMLEP00000036306.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000036306.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000036306.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_011820823.1; XM_011965433.1.
DR AlphaFoldDB; A0A2K6A8B3; -.
DR Ensembl; ENSMLET00000059907.1; ENSMLEP00000036306.1; ENSMLEG00000042237.1.
DR GeneID; 105528623; -.
DR CTD; 2313; -.
DR GeneTree; ENSGT00940000158261; -.
DR OMA; AXSLLAY; -.
DR OrthoDB; 2882052at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd08541; SAM_PNT-FLI-1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR035573; SAM_PNT-FLI-1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF161; FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 46..132
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 215..295
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 142..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 43649 MW; E27AB7E4A8E9A24A CRC64;
MEGGLAGEWA RESPVDCSVS KCSKLVGGGE SNPMNYNSYM DEKNGPPPPN MTTNERRVIV
PADPTLWTQE HVRQWLEWAI KEYGLMEIDT SFFQNMDGKE LCKMNKEDFL RATTLYNTEV
LLSHLSYLRE SSLLAYNTTS HTDQSSRLSV KEDPSYDSVR RGAWGNNMNS GLNKSPPLGG
AQTISKNTEQ RPQPDPYQIL GPTSSRLANP GSGQIQLWQF LLELLSDSAN ASCITWEGTN
GEFKMTDPDE VARRWGERKS KPNMNYDKLS RALRYYYDKN IMTKVHGKRY AYKFDFHGIA
QALQPHPTES SMYKYPSDIS YMPSYHAHQQ KVNFVPPHPS SMPVTSSSFF GAASQYWTSP
TGGIYPNPNV PRHPNTHVPS HLGSYY
//
