ID   A0A2K6A8R2_MANLE        Unreviewed;       854 AA.
AC   A0A2K6A8R2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=A-kinase anchoring protein 4 {ECO:0000313|Ensembl:ENSMLEP00000036435.1};
GN   Name=AKAP4 {ECO:0000313|Ensembl:ENSMLEP00000036435.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000036435.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000036435.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the AKAP110 family.
CC       {ECO:0000256|ARBA:ARBA00005764}.
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DR   AlphaFoldDB; A0A2K6A8R2; -.
DR   STRING; 9568.ENSMLEP00000036435; -.
DR   Ensembl; ENSMLET00000060037.1; ENSMLEP00000036435.1; ENSMLEG00000042338.1.
DR   GeneTree; ENSGT00940000153313; -.
DR   OMA; VMKLCMI; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0097224; C:sperm connecting piece; IEA:Ensembl.
DR   GO; GO:0097229; C:sperm end piece; IEA:Ensembl.
DR   GO; GO:0035686; C:sperm fibrous sheath; IEA:Ensembl.
DR   GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR   GO; GO:0097228; C:sperm principal piece; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0051018; F:protein kinase A binding; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0045184; P:establishment of protein localization; IEA:Ensembl.
DR   GO; GO:0120316; P:sperm flagellum assembly; IEA:Ensembl.
DR   GO; GO:0007178; P:transmembrane receptor protein serine/threonine kinase signaling pathway; IEA:Ensembl.
DR   InterPro; IPR020799; AKAP_110.
DR   InterPro; IPR018292; AKAP_110_C.
DR   InterPro; IPR018459; RII-bd_1.
DR   InterPro; IPR008382; SPHK1-interactor_AKAP_110.
DR   PANTHER; PTHR10226; A KINASE ANCHOR PROTEIN; 1.
DR   PANTHER; PTHR10226:SF8; A-KINASE ANCHOR PROTEIN 4; 1.
DR   Pfam; PF05716; AKAP_110; 3.
DR   Pfam; PF10522; RII_binding_1; 1.
DR   SMART; SM00807; AKAP_110; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          215..232
FT                   /note="RII binding"
FT                   /evidence="ECO:0000259|Pfam:PF10522"
FT   DOMAIN          292..519
FT                   /note="A-kinase anchor 110kDa C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05716"
FT   DOMAIN          523..731
FT                   /note="A-kinase anchor 110kDa C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05716"
FT   DOMAIN          756..854
FT                   /note="A-kinase anchor 110kDa C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05716"
FT   REGION          185..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          648..676
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   854 AA;  94657 MW;  4C00D0653A277675 CRC64;
     LMAYSDTTTM SDDIDWLRSH RGVCKVDLYN PAGQQDQDRK VICFVDVSTL NVEDKDYKDA
     AGSSSEGKLN LGNLEEKEII VIKDTEKKDQ SKTEGSVCLF KQAPSDPVSV LNWLLSDLQK
     YALGFQHALS PSASTCKHKV GDTEGEYHTA SSENCYSVYA DQVNIDYLMN RPQNLRLEIA
     AAKNTNNNQS PSAPPAKPPS TQRAVISPDG ECSIDDLSFY VNRLSSLVIQ MAHKEIKEKL
     EGRSKCLHHS IYPSPGNKER ISSRTAVSKI ASEMAHEAVE LTAAEMRGTE EESREGGQKS
     FLYSELSNKS KSGDKQMSQR DSKEFADSIS KGLMVYANQV ASDMMVSVMK TLKVHSSGKP
     IPACVVLKRV LLRHTKEIVS DLIDSCMKNL HNITGVLMTD SDFVSAVKRN LFNQWKQNAA
     DIMEAMLKRL VSALIGEEKE TKSQSLSYAS LKAGSHDPKC RNQSLEFSTM KAEMKGRDKG
     KMKSDPYKTL TSAEKVGEHI LKEGLTIWNQ KQGNPCKVAT KACSNKDEKG EKINASTDSL
     AKDLIVSALK LIQYHLTQQT NGKDTCEEDC PGSTMGYMAQ STQYEKCGGG QSAKALSVKH
     LESHRAPGPS TCQKEDQPLD SQKMDMSNIV LMLIQKLLNE NPFKCEDPCE GENKHSEPRA
     SKATYMSKRS DKGEEQCQDH QELDFISGMK QVNWQFIDKL VESVMKLCLI MAKYSNDGAA
     LAELEEQAAS ADKPNFRGTR CIHSGAMPQN YQDSLGHEVI VNNQCSTNSL QKQLQAVLQW
     IAASQFNVPM LYFMGDKDGQ LEKLPQVSAK AAEKGYSVGG LLQEVMKFAK ERQLDEAVGK
     VARKQLLDWL LANL
//