ID A0A2K6A9W8_MANLE Unreviewed; 1799 AA.
AC A0A2K6A9W8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Kinesin family member 1B {ECO:0000313|Ensembl:ENSMLEP00000036842.1};
GN Name=KIF1B {ECO:0000313|Ensembl:ENSMLEP00000036842.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000036842.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000036842.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR Ensembl; ENSMLET00000060447.1; ENSMLEP00000036842.1; ENSMLEG00000041753.1.
DR GeneTree; ENSGT00940000157445; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22727; FHA_KIF1B; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR PANTHER; PTHR47117:SF1; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 5..355
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 531..587
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1622..1720
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1471..1492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1539..1581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 650..706
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1471..1491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1799 AA; 202247 MW; 5C18BF498EAE8DCB CRC64;
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT
SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP
QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED
LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKVCKKKK
KTDFIPYRDS VLTWLLRENL GGNSRTAMVA ALSPADINYD ETLSTLRYAD RAKQIKCNAV
INEDPNAKLV RELKEEVTRL KDLLRAQGLG DIIDIDPLID DYSGSGSKSS MGSLTSSPSS
CSLNSQVGLT SVTSIQERIM STPGGEEAIE RLKESEKIIA ELNETWEEKL RKTEAIRMER
EALLAEMGVA IREDGGTLGV FSPKKTPHLV NLNEDPLMSE CLLYYIKDGI TRVGQADAER
RQDIVLSGAH IKEEHCIFRS ERNNSGEVIV TLEPCERSET YVNGKRVSQP VQLRSGNRII
MGKNHVFRFN HPEQARAERE KTPSAETPSE PVDWTFAQRE LLEKQGIDMK QEMEKRLQEM
EILYKKEKEE ADLLLEQQRL DYESKLQALQ KQVETRSLAA ETTEEEEEEE EVPWTQHEFE
LAQWAFRKWK SHQFTSLRDL LWGNAVYLKE ANAISVELKK KVQFQFVLLT DTLYSPLTPE
LLPTEMEKTH EDRPFPRTVV AVEVQDLKNG ATHYWSLEKL KQRLDLMREM YDRAGEMASS
AQDESETTVT GSDPFYDRFH WFKLVGSSPI FHGCVNERLA DRTPSPTFST ADSDITELAD
EQQDEMEDFD DEAFVDDAGS DAGTEEGSDL FSDGHDPFYD RSPWFILVGR AFVYLSNLLY
PVPLIHRVAI VSEKGEVRGF LRVAVQAIAA DEEAPDYGSG IRQSGTAKIS FDNEYFNQSD
FSSVAMTRSG LSLEELRIVE GQGQSSEVIT PPEEINRMND LDLKSSTLLD GKMVMEGFSE
EIGNHLKLGS AFTFRVTVLQ ASGILPEYAD IFCQFNFLHR HDEAFSTEPL KNNGRGSPLG
FYHVQNIAVE ITESFVDYIK TKPIVFEVFG HYQQHPLHLQ GQELNSPPQP CRRFFPPPMP
LSKPETSLGT MAKPHLYKKM YIPAVVDHTA GLPCQGTFLL HQGIQRRITV TIIHEKGSEL
HWKDVRELVV GRIRNKPEVD EAAVDAILSL NIISAKYLKS SHNSSRLRWE DHLSPGTLVT
VLCLHFISTY PVCFQLDHCI QPAVITKDVC MVFYSRDAKI SPPRSLRSLF GSGYSKSPDS
RRRKILDTSV AYVRGEENLA GWRPRGDSLI LEHQWELEKL ELLHEVEKTR HFLLLRERLG
DSIPKSMSDS LSPSLSSGTL STSTSISSQI STTTFESAIT PSESSGYDST DIESLVDREK
ELATKCLQLL THTFNREFSQ VHGSISDCKL SDISPIGRDP SESSFSSATL TPSSTCPSLV
DSRSNSLDQK TPEANSRASS PCPEFEQFQI VPAVETPYLA RAGKNEFLNL VPDIEEIRPG
SVVSKKGYLH FKEPLYSNWA KHFVVVRRPY VFIYNSDKDP VERGIINLST AQVEYSEDQQ
AMVKTPNTFA VCTKHRGVLL QALNDKDMND WLYAFNPLLA GTIRPGHLAS ETIREDKSVS
FSCQQVFQDK RGKGKPPETS VALPVVLGLF YTILYFPCSD LSVAPSLRHS GKYLLAPTW
//