ID A0A2K6AD80_MANLE Unreviewed; 4012 AA.
AC A0A2K6AD80;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Fraser extracellular matrix complex subunit 1 {ECO:0000313|Ensembl:ENSMLEP00000038000.1};
GN Name=FRAS1 {ECO:0000313|Ensembl:ENSMLEP00000038000.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000038000.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000038000.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR RefSeq; XP_011821612.1; XM_011966222.1.
DR STRING; 9568.ENSMLEP00000038000; -.
DR Ensembl; ENSMLET00000061609.1; ENSMLEP00000038000.1; ENSMLEG00000043062.1.
DR GeneID; 105529136; -.
DR KEGG; mleu:105529136; -.
DR CTD; 80144; -.
DR GeneTree; ENSGT00940000162130; -.
DR OMA; NSGMRVQ; -.
DR OrthoDB; 5470912at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0003338; P:metanephros morphogenesis; IEA:Ensembl.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR CDD; cd00064; FU; 12.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 5.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00261; FU; 14.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 5.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS01208; VWFC_1; 4.
DR PROSITE; PS50184; VWFC_2; 6.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..4012
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014353809"
FT TRANSMEM 3906..3926
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..88
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 93..153
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 157..217
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 219..279
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 283..343
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 347..417
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 1102..1197
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1217..1308
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1329..1438
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1463..1559
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1595..1689
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1710..1810
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1833..1936
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1957..2057
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2078..2177
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2199..2291
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2311..2404
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2439..2536
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 4012 AA; 443593 MW; 789814758056C2AA CRC64;
MGVLKVWLGL ALALAEFAVL PHHSEGACVY QGSLLADATI WKPDSCQNCR CHGDIVICKP
AVCRNPQCAF EKGEVLQIAA NQCCPECVLR TPGSCHYEKK IHEHGTEWAS SPCSVCSCNH
GEVRCTPQPC PPLSCGHQEL AFIPEGSCCP VCVGPGKPCS YEGRVFQDGE DWQLSRCAKC
LCRNGVAQCF TAQCQPLFCN QDETVVRVPG KCCPQCSARS CSAAGQVYEH GEQWSENACT
TCICDRGEVR CHKQACLPLR CGKGQSRARR HGQCCEECVS PAGSCSYDGV VRYQDEMWKG
SACEFCMCDH GQVTCQTGEC AKVECAQGEE LIHLDGKCCP ECISRNGYCV YEGNGKFMSS
NASEVKRIPE GEKWEDGPCK VCECRGTQVT CYKPSCPPCP VGTLALEVKG RCCPDCTSVH
CHPDCLTCSH SPDHCDLCQD PTKLLQNGRC VHSCGLGFYQ AGSLCLACQP QCSTCTSGLE
CSSCQPPLLM RHGQCVSTCG DGFYQDHHSC AVCHESCAGC WGPAEKHCLA CRDPLHVLRD
GRCDSSCGKG FYNRRGTCSA CDQSCETCGP SSPRCLTCTE KTVLHDGKCM SECPGGYYAD
AIGRCKVCHN SCASCSGPTA SHCTACSPPK ALRQGHCLPH CGEGFYSDYG ICKACHFSCL
ACMGPAPSHC TGCKKPEEGL QVEQLSGAGI PSGECLAQCR AHFYLESTGI CEACHQSCFR
CAGKSPRNCT DCGPSHVLLD GQCLSQCPDG YFHQEGSCTE CHPTCRQCRG PLESDCISCY
PHVSLTNGNC RTSCREEQFL NLVGYCADCH PLCQHCAADL HNTGSICLRC HNARYLLLGD
HCVPDCPSGY YAERGACKKC HSSCRTCQGR GPFSCSSCDT NLVLSHTGTC STTCFPGHYL
DDNHVCQSCN THCGSCDSQA SCTSCRDPNK VLLFGECQYE SCAPQYYLDF STNTCKECDW
SCSACSGPLK TDCLQCMDGY ILQDGACVEQ CRSSFYQDSG LCKNCDSYCL QCQGPHECTR
CEGPFLLLEA QCVQECGKGY FADHVKHKCT ACPRGCLQCS HRDRCHLCDH GFFLKSGLCV
YNCVPGFSAH SSNETCSGKI HTPSLHVNGS LILPIGSIKP LDFSLLNVQD QEGRVEDLLF
HVVSAPTNGQ LVLSRNGKEV QLDKAGRFSW NDVNEKKVRF VHSKEKLRKG YFFLKISDQQ
FFSEPQLINI QAFSTQAPYV LRNEVLHISR GERATITTQL LDIRDDDNPQ DVVVEVIDPP
LHGQLLQTLQ SPAAPTYQFQ LDELSRGLLH YVHDGSDSTS DVAVLQANDG HSFHNILFQV
KTVPQNDRGL QLVANSMVWV PEGGMLQITN RILQAEAPGA SAEEIIYKIT QDYPQFGEVV
LLVNMPADSP ADEGQHLPDG RTATPTSTFT QQDINEGIVW YRHSGAPAQS DSFRFQVSSA
SDAQTHLESR MFNIAILPQT PEAPKLSLEA SLHMTAREDG LTVIQPHSLS FINSERPSGK
IVYNITLPLH PNQGIIEHRD HPHSPIRYFT QEDINQGKVM YRPPPAAPHL QELMAFSFAG
LPESVKFHFT VSDGEHTSPE MVLTIHLLPS DQQLPVFQVT APRLAVSPGG STSVGLQVVV
RDAETAPEEL FFELRRPPQH GVLLKHTAEF RRPMATGDTF TYEDIEKNAL QYIHDGSSAR
EDSMEISVTD GLTVTMLEVR VEVSLSEDQG PRLAAGSSLS ITVASKSTAI ITRSHLAYVD
DSSPDPEIWI RLNYLPTYGT LLRTSGPEVE ELSEFSNFTM EDINNKKIRY SAVFETDGHL
VTDSFYFSVS DMDHNHLDNQ MFTIMITPAE NPPPVIAFAD LITVDEGGRA PLSFHHFFAT
DDDDNLQGDA IIKLSALPKY GCIENTGTGD RFGPETTSDL EASFPVQDVL ENYIYYFQSV
HESIEPTHDI FSFYVSDGTS RSEIHSINIT IERKNDEPPR MTLQPLRVQL SSGVVISNSS
LSLQDMDTPD NELIFALTRK PDHGHLLQRQ TASEPLENGR VLAQGSTFTY QDILTGLVGY
VPGVPGMAVD EFQFSLTDGL HVDTGRMKIY IELPTSDTPH LAINRGLQLS AGSVAHITEQ
HLKVTDIDSD DRQVMYIMKE DPGAGHLQMV KHGNLEQISV KGPVRSFTQA DISQGHVEYS
HGTGEPGGSF AFKFDVVDGE GNRLIDQSFS ISVLEDKSPP VIITNKGLVL DENSVKKITT
LQLSATDQDS GPTELIYRIT RQPQLGHLEH ATSPGIQISS FTQADLTSRN VQYVHSSEAE
KHSDAFSFTL SDGVNEVTQT FRITLHPVDD LLPIVQNSGM RVQEGVRKTI TEFELKAVDA
DTEAESVTFT IVQPPRHGTI ERTSNGQHFH LTSTFTMEDI YQNRVSYSHD SSNSLKDWFT
FTVSDGTNPF FIIEEGGKEI MTAAPQSFWV DILPVDDGTP RIVTNLGLQW LEYMGGKATN
LITKKELLTV DPDTEDAQLV YEITTSPKHG FVENKLQPSR AAATFTQEDV NLGLIRYVLH
EEKIHEMMDS FQFLVKDSKP NVVSDNVFHI QWSLISFKYT SYNVSEKAGS VSVTVQRTGN
LNQYAIVLCR TEQGTASSSS RVSSQPGQQD YVEYAGQVQF DEREDTKSCT IVINDDDVFE
NVESFTVELS MPAYALLGEF TRAKVIINDT EDEPTLEFDK KIYRVNESAG FLFAPIERKG
DASSIVSAVC YTVPKSAMGS SLYALESGSD FKSRGMSAAS RVIFGPGVTM STCDVMLIDD
SEYEEEEEFE IALADASDNA RIGRVATAKV LISGPNDAST VSLGNTAFTV SEDAGTVKIP
VIRHGTDLST FTSVWCATRP SDPASATPGV DYVPSSRKVE FGPGVTEQYC TLTILDDTQY
PVIEGLETFV VFLSSAQGAE LTKPFQAVIA INDTFQDVPS MQFAKDLLLV KEKEGILHVP
ITRSGDLSYE SSVRCYTQSH SAQVMEDFEE RRNADSSRIT FLKGDKVKNC TVYIHDDSMF
EPDEQFRVYL GLPLGNHWSG ARIGKNNMAT ITISNDEDAP TIEFEEAAYQ IREPAGPDAI
AILNIKVIRR GDQNRTSKVR CSTRDGSAQS GVDYYPKSRV LKFSPGVDHI FFKVEILSNE
DREWHESFSL VLGPDDPVEA VLGDVTTATV TILDQEAAGS LILPAPPIVV TLADYDHVEE
VTKEGVKKSP SPGYPLVCVT PCDPHFPRYA VMKERCSEAG INQTSVQFSW EVAAPTDGNG
ARSPFETITD NTPFTSVNHM VLDSIYFSRR FHVRCVAKAV DKVGHVGTPL RSNIVTIGTD
SAICHTPVVA GTSRGFQAQS FIATLKYLDV KHKEHPNRIH ISVQIPHQDG MLPLISTMPL
HNLHFLLSES IYRHQHVCSN LVTTYDLRGI SEAGFLDDVV YDSTALGPGY DRPFQFDPSV
REPKTIQLYK HLNLKSCVWT FDAYYDMTEL IDVCGGSVTA DFQVRDSAQS FLTVHVPLYV
SYIYVTAPRG WASLEHHTEM EFSFFYDTVL WRTGIQTDSV LSARLQIIRI YIREDGRLVI
EFKTHAKFRG QFVMEHHTLP DVKSFILTPD HLGGIEFDLQ LLWSAQTFDS PHQLWRATSS
YNRKDYSGEY TIYLIPCTVQ PTQPWVDPGE KPLACTAHAP ERFLIPIAFQ QTNRPVPVVY
SLNTEFQLCN NEKVFLMDPN TSDMSLAEMD YKGAFSKGQI LYGRVLWNPE QNLNSAYKLQ
LEKVYLCTGK DGYVPFFDPT GTIYNEGPQY GCIQPNKHLK HRFLLLDRNQ PEVTDKYFHD
VPFEAHFASE LPDFHVVSSM PGVDGFTLKV DALYKVEAGH QWYLQVIYII GPDTISGPRV
QRSLTAPLRR NRRDLVEPSG RLTLDDSLIY DNEGDQVKNG TNMKSLNLEM QEPAVAASLS
QTGASIGSAL AAIMLLLLVF LVACFINRKC QKQRKKKPAE DILEEYPLNT KVEVPKRHPD
RVEKNVNRQY CTVRNVNILS EPEAAYMFKG AKVKRLNLEV RVHNNLQDGT EV
//
