ID A0A2K6ADI0_MANLE Unreviewed; 716 AA.
AC A0A2K6ADI0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=LDL receptor related protein 10 {ECO:0000313|Ensembl:ENSMLEP00000038124.1};
GN Name=LRP10 {ECO:0000313|Ensembl:ENSMLEP00000038124.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000038124.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000038124.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR RefSeq; XP_011846019.1; XM_011990629.1.
DR AlphaFoldDB; A0A2K6ADI0; -.
DR STRING; 9568.ENSMLEP00000038124; -.
DR Ensembl; ENSMLET00000061733.1; ENSMLEP00000038124.1; ENSMLEG00000043127.1.
DR GeneID; 105547170; -.
DR KEGG; mleu:105547170; -.
DR CTD; 26020; -.
DR GeneTree; ENSGT00940000160783; -.
DR OMA; PSATACY; -.
DR OrthoDB; 2916406at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:Ensembl.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR GO; GO:0006869; P:lipid transport; IEA:Ensembl.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF17; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 10; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 4.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..716
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014447473"
FT TRANSMEM 444..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..308
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 593..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 143..155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 150..168
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 162..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 341..356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 384..399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 402..414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 409..427
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 421..436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 716 AA; 76377 MW; A88C0CA78508AB0C CRC64;
MLLATLLLLL LLLLGGALAH PDRIIFPNLA CEDPPAVLLE VQGTLQRPLV RDSRSSPANC
TWLILGSKEQ TVTVRFQKLH LACGSEHLTL RSPLQPPISL CEAPPSPLQL PGGNVTITYS
YAGARAPMGQ GFLLSYSQDW LMCLQEEFQC LNHRCVSAVQ RCDGIDACGD GSDEAGCSSD
PFPGLTPRPI PSLPCNLTLE DFYGVFSSPG YAHLASVSHP QSCHWLLDPH DGRRLAVRFT
ALDLGFGDAV HVFDGPGPPE SSRLLRSLTH FSNGKAVTVE TLSGQAVVSY HTVAWSNGRG
FNATYHVRGY CLPWDRPCGL GSGLGAGEGL GERCYSEAQR CDGSWDCADG TDEEDCPGCP
PGHFPCGAAG TSGATACYLP ADRCNYQTFC ADGADERRCR HCQPGNFRCR DEKCVYETWV
CDGQPDCADG SDEWDCSYVL PRKVITAAVI GSLVCGLLLV IALGCTCKLY AIRTQEYSIF
APLSRMEAEI VQQQAPPSYG QLIAQGAIPP VEDFPTENPN DNSVLGNLRS LLQILRQDMT
PGGGSGARRR QRGRLMRRLV RRLRRWGLLP RTNTPARASE ARSQVTHSAA PLEALDGGTG
PACEGGAVGG QDGEQAPPLP IKAPLPSAST SPAPTTVPEA PGPLPSLPLE PSLLSGVVQA
LRGRLLPSLG PPGPTRSPAG PHTAVLAPED EDDVLLVPLA EPGVWVAEAE DEPLLT
//
