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Database: UniProt
Entry: A0A2K6AEN2_MANLE
LinkDB: A0A2K6AEN2_MANLE
Original site: A0A2K6AEN2_MANLE 
ID   A0A2K6AEN2_MANLE        Unreviewed;      4000 AA.
AC   A0A2K6AEN2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=PKHD1 ciliary IPT domain containing fibrocystin/polyductin {ECO:0000313|Ensembl:ENSMLEP00000038521.1};
GN   Name=PKHD1 {ECO:0000313|Ensembl:ENSMLEP00000038521.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000038521.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000038521.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 9568.ENSMLEP00000038521; -.
DR   Ensembl; ENSMLET00000062133.1; ENSMLEP00000038521.1; ENSMLEG00000043301.1.
DR   GeneTree; ENSGT00940000160697; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
DR   GO; GO:1904054; P:regulation of cholangiocyte proliferation; IEA:Ensembl.
DR   GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
DR   CDD; cd00603; IPT_PCSR; 5.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR   Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 2.
DR   InterPro; IPR019316; G8_domain.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR037524; PA14/GLEYA.
DR   InterPro; IPR006626; PbH1.
DR   InterPro; IPR012334; Pectin_lyas_fold.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   PANTHER; PTHR46769:SF1; FIBROCYSTIN; 1.
DR   PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR   Pfam; PF10162; G8; 2.
DR   Pfam; PF01833; TIG; 8.
DR   SMART; SM01225; G8; 2.
DR   SMART; SM00429; IPT; 6.
DR   SMART; SM00710; PbH1; 9.
DR   SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR   SUPFAM; SSF81296; E set domains; 7.
DR   SUPFAM; SSF51126; Pectin lyase-like; 2.
DR   PROSITE; PS51484; G8; 2.
DR   PROSITE; PS51820; PA14; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..4000
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014326110"
FT   TRANSMEM        3791..3814
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          322..485
FT                   /note="PA14"
FT                   /evidence="ECO:0000259|PROSITE:PS51820"
FT   DOMAIN          1901..2022
FT                   /note="G8"
FT                   /evidence="ECO:0000259|PROSITE:PS51484"
FT   DOMAIN          2716..2842
FT                   /note="G8"
FT                   /evidence="ECO:0000259|PROSITE:PS51484"
FT   REGION          3821..3856
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3840..3856
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4000 AA;  437943 MW;  606061E3DFC62BA7 CRC64;
     MTAWLISLMG VQALLLAVPH LSLHIEPEEG SLAGGTWITV IFDGLESGVL YPNNGSQLEI
     HLVNTNMVAP ALPSIPCDVF PVFLDLPVVT CRTRSLLSEA HEGLYSLEAY FREQLVSSPS
     PGSRDSCTFK FSKAQTPIVH QVYPPSGVPG KLIHVYGWIM TGRLETFDFD AEYIDSPVIL
     EAQGDKWVTP CSLVNRQTGS CYPIQEDHGL GTLQCHVEGD YIGSQNVSFS VFNKGKSMVH
     KKAWLISAKQ DLFLYQTHSE ILSVFPETGS LGGRTDITIT GDFFDNSAQV TIAGIPCDIR
     HVSPRKIECT TRAPGKDARL TTPQPGNRGL LFEVGDAVEG LELTEATPGY RWQIVPNASS
     PFGFWSKERQ PFRARLSGFF VAPETNNYTF WIQADSQASL HFSWSEEPRT KVKVASISVG
     TADWFDSWEQ NRDEGTWQQK TPKLELLGGA KYYLEAEHHG IAPSRGMRIG VQIHNTWLNP
     DVVTTYLREK HQIRARAQRL PEVQVLNVSG RGNFFLTWDN VSSQPIPANA TAHLIQTTIE
     ELLAVKCKLE PLWANILLRL GFEGGAVPGF THSDCLFHHE CSTLLYSPRH MLGKDPPGLG
     TRALTGEDCK CSLRAQFHST LFFSWQFRCT DLWETCVRCS GDLQPPPANS PVLVHQIDLV
     PLVQETGLFY VDEIIIADTN VTVSQADSGT ARPGGNLVES VSVVGSPPVY SVTSWLAGCG
     TELPLITARS VPTEGTEEGS GLVLATTQRQ QRPSPPLGGH FRIQLPNTVI SEVPVQISAH
     HLHQLLQNNA DDFTSRYLNA SDFSVKEDLY TCYERVWTLS WSTQIGDLPN FIRVSDENLT
     GVNPAAAMRV VYDGGVFLGP IFGDMLATAN QHSQVVVRVN DVPAHCPGSC SFQYLQGSTP
     CVHSVWYSVD GDVNLMIYIT GTGFSGDSQF LQVTVNKMNC KVSFSNQTNV VCQTDLLPVG
     VHRILMLVRP SGLAISATGE DLFLNVEPRL DTVEPSTAAD IGGLWATIRG SSLEGVSLVL
     FGSYSCAINV TTSNSSRIQC KVPPRGKDGH VVNVTVIRGN HSAVLPRAFT YVSSLNPVIV
     TLSRNTSNIA GGETLVIGVA RLVNYTDLDV EVHIQDALAL VHTQSAWGLE VALPALPAGL
     HRISVSINGI SIHSQGVDLH IQYLTEVFSI EPCCGSLLGG TILSISGIGF SRDPALVWVL
     VGNRSCDIVN LTEASIWCET LPAPQIPDAG APTVPAAVEV WAGNRSFAHG PSPSLVGNGF
     TFMYEAAATP VVTAMQGEIT NSSLSLRVGG SNLSNSVILL GNLNCDAETQ SFQGNSSLSG
     CSVPLHSLEA GIYPLQVRQK QMGFANMSAV PQQFAVTPRI MAIFPSQGSA CGGTILTVRG
     LLLNSRTRSV RVDLSGPFTC EILSLGDHTI LCQVSLEGDP LPGASFSLNV TVLVNGITSE
     CHGNCTLFIR EEASPVMDTL STNTSGSLTT VLIRGERLGT TADEPMVFVD DQLLCNVTFF
     NASHVVCQTR DLAPGPHYLS VFYTRNGYAC SGNVSRHFYI MPQVFHYFPK NFSIHGGSLL
     TIEGTGLRGQ NTTSVYIDQQ ACLMVNIGAE LIRCIVPTGN GSAALEIEVD GPRYHIGVIG
     YSNAFTPELI SISQSDGILT FAVAQISGAA NIDIFIGMSP CVGVSGNHTV LQCVVPSLPA
     GEYHVRGYDC IRGWASSVLV FTSRVIITAV KENFGCLGGR LVHVFGAGFS PGNVSAAVCG
     APCRVLANAT VSAFSCLVLP LDVSLAFLCG LKHEEDSCEA ARHTYVQCDL TVAVGTERML
     ESWPYLYICE ESSQCLFVPD HWAESMFPSF SGLFVSPKVE RDEVLIYNSS CNITMETEAE
     MECETPNQPI TVKITEIRKR WGQNTQGNFS LQFCRRWSRT HSWFPERLPQ DGDNVTVENG
     QSLLLDTNTS VLNLLLIKGG KLIFMAPGPI ELRAHAILVS DGGELRIGSE DKPFQGRAQI
     TLYGSSHSTP FFPYGVKFLA VRNGTLSLHG SLPEVIVTRL RATAHARDTV LALEDAVDWH
     PGDEVVIISG TGVEGAKPME EIVTVETVQD TDVYLKSPLR YSHNFTENWV AGEHHILKAT
     VALLSRSITI QGNLTNEREK LLLSCQEANA PEGNLQHCLY SMSEKMLGSR DMGARVIIQS
     FPEEPSQVQL KGVQFQVLGQ AFHKHLSSLT LVGAMRESFI QGCTVRSSFS RGLSMCGTLG
     LKVDSNVFYN ILGHALLVGT CMEMRYISWE AIHGRKYDWS GHGNIIRNNV IIQVSGAEGL
     SNPEMLTPSG IYIRSPTNVI EGNRVWGAGY GYFFHLVTNQ TSQAPLLSFT QNIAHSCTRY
     GLFVYPKFQP PWDNVTGITL FQSFTVWESA GGAQIFRSSN LRLKNFQVYS CRDFGIDILE
     SDANTSVTDS LLLGHFAHKG SLCMSSGIKT PKRWELMVSN TTFVNFDLIN CVAIRTCSDC
     FQGQGGFTVK TSQLKFINSS NLVAFPFPHA AILEDLDGSL SGKNRSHILA SMETLSASCL
     VNASFGRVVH GSACGGGVLF HRMSIGLANA PEVSYDLTMT DSRNKTTTVN YVRDTLSNPH
     GWMALLLDQE TYSLRSENLW INRSLQYSAT FDNFAPGNYL LLVHTDLPPY PDILLRCGSR
     VGLSFPFLPS PGQNQGCDWF FNSQLRQLTY LVSGEGRVRV ILWVKEGMPP TISASTSAPE
     SALKWSLPET WQGVEEGWGG YNNSLPGPGD DVLILPNRTV LVDTDLPFFK GLYVMGTLDF
     PVDRSNVLSV ACMVIAGGEL KVGTLENPLE KEQKLLILLR ASEGVFCDRL NGIHIDPGTI
     GVYGKVQLYS AYSKNSWTHL GADIASGNER IIVEDAVDWR PHDKIVLSSS SYEPHEAEVL
     TVKEVKGHHV RIHERLKHRH IGSVHVTEDG RHIRLAAEVG LLTRNIQIQP DVSCRGRLFV
     GPLRKSSREE FSGVLQLLNV EIQNFGSPLY SSVEFSNVSE GSWIISSTLH QSCGGGIHAT
     ASHGVLLNDN IVFGTAGHGI DLEGQAYTVT NNLVVLMTQP AWSTIWVAGI KVNQAKDINL
     HGNVVAGSER IGFHIRGHKC SCGLLWSDNV AHSSLHGLHL YKESGLDNCT RISGFLAFKN
     FDYGAMLHIE NSVEIENITL VDNTIGLLAV VYVFSAPQNS IKKVQIVLRN SIIVATSSSF
     DCIQDKVKPL SANLTSTDRA PSNPRGGRIG ILWPVFTSEP NQWPQEPWHK VRNDHSISGI
     MKLQDVTFSS FVKSCYSDDL DVCILPNAEN TGIMHPITAE RTRMLKIKDK NKFYFPSLQP
     RKDLGKVVCP ELDCASPRKY LFKDLDGRAL GLPPPVSIFP KTEAEWTTSF FNAGTYREEQ
     KCTYRFLMQG FVCKQTDQVV LILDGADATW AIQKLYPVVS VTSGFVDIFS SVNANIPCST
     SGSVSTFYSI LPTRQITKVC FMDQTPQVLR FFLLGNKSTS KLLLAVFYHE LQNPHVFLGE
     SFIPPTLVQS ASLLLNESIG ANYFNIMDNL LYVVLQGEEP IEIRSSVSIN LALTVMVSVL
     EKGWEIVILE RLTNFLQIGQ NQIRFLREIP GHEETLKAIA DSRAKRKRNC PTVTCASHYR
     RVSQRRPLMM EMNSYRSSPP TTVETMSKVI VIEIGDSPTV RSTGMISSLS SNKLQNLAHQ
     VITAQQTGVL ENILNMTIGA LLVTQSKGVI GYGNSSSFKT GNLIYIRPYV LSVLVQPSDG
     EVGNELPVQP QLVFLDEQNR RVESLGPPSE PWTISASLEG ASDSVLKGVN FTARSQSFAV
     LPVTRKEKST IILAASLSSV ASWLALSCLV CCWLKRSKSR KTKPEEIPES QTNNENNHIH
     TSSKCRESQG PKKEDTVVAE DMRMKVMLGR LNQCPHQLMN GVSRRKVSRH IVREEEAAVP
     APGTTGITSH EHTCAPGAPA QQVYLQETGN WKEGQEQLLR YQLAGQDQLL LQERQQLPGQ
     SWLSKQSGSL GLSQEKKASC GATEAFCLHS VHLEAIQEQL
//
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