ID A0A2K6AEN2_MANLE Unreviewed; 4000 AA.
AC A0A2K6AEN2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=PKHD1 ciliary IPT domain containing fibrocystin/polyductin {ECO:0000313|Ensembl:ENSMLEP00000038521.1};
GN Name=PKHD1 {ECO:0000313|Ensembl:ENSMLEP00000038521.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000038521.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000038521.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9568.ENSMLEP00000038521; -.
DR Ensembl; ENSMLET00000062133.1; ENSMLEP00000038521.1; ENSMLEG00000043301.1.
DR GeneTree; ENSGT00940000160697; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
DR GO; GO:1904054; P:regulation of cholangiocyte proliferation; IEA:Ensembl.
DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
DR CDD; cd00603; IPT_PCSR; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 2.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF1; FIBROCYSTIN; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF01833; TIG; 8.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 6.
DR SMART; SM00710; PbH1; 9.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF81296; E set domains; 7.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..4000
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014326110"
FT TRANSMEM 3791..3814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 322..485
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 1901..2022
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 2716..2842
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT REGION 3821..3856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3840..3856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4000 AA; 437943 MW; 606061E3DFC62BA7 CRC64;
MTAWLISLMG VQALLLAVPH LSLHIEPEEG SLAGGTWITV IFDGLESGVL YPNNGSQLEI
HLVNTNMVAP ALPSIPCDVF PVFLDLPVVT CRTRSLLSEA HEGLYSLEAY FREQLVSSPS
PGSRDSCTFK FSKAQTPIVH QVYPPSGVPG KLIHVYGWIM TGRLETFDFD AEYIDSPVIL
EAQGDKWVTP CSLVNRQTGS CYPIQEDHGL GTLQCHVEGD YIGSQNVSFS VFNKGKSMVH
KKAWLISAKQ DLFLYQTHSE ILSVFPETGS LGGRTDITIT GDFFDNSAQV TIAGIPCDIR
HVSPRKIECT TRAPGKDARL TTPQPGNRGL LFEVGDAVEG LELTEATPGY RWQIVPNASS
PFGFWSKERQ PFRARLSGFF VAPETNNYTF WIQADSQASL HFSWSEEPRT KVKVASISVG
TADWFDSWEQ NRDEGTWQQK TPKLELLGGA KYYLEAEHHG IAPSRGMRIG VQIHNTWLNP
DVVTTYLREK HQIRARAQRL PEVQVLNVSG RGNFFLTWDN VSSQPIPANA TAHLIQTTIE
ELLAVKCKLE PLWANILLRL GFEGGAVPGF THSDCLFHHE CSTLLYSPRH MLGKDPPGLG
TRALTGEDCK CSLRAQFHST LFFSWQFRCT DLWETCVRCS GDLQPPPANS PVLVHQIDLV
PLVQETGLFY VDEIIIADTN VTVSQADSGT ARPGGNLVES VSVVGSPPVY SVTSWLAGCG
TELPLITARS VPTEGTEEGS GLVLATTQRQ QRPSPPLGGH FRIQLPNTVI SEVPVQISAH
HLHQLLQNNA DDFTSRYLNA SDFSVKEDLY TCYERVWTLS WSTQIGDLPN FIRVSDENLT
GVNPAAAMRV VYDGGVFLGP IFGDMLATAN QHSQVVVRVN DVPAHCPGSC SFQYLQGSTP
CVHSVWYSVD GDVNLMIYIT GTGFSGDSQF LQVTVNKMNC KVSFSNQTNV VCQTDLLPVG
VHRILMLVRP SGLAISATGE DLFLNVEPRL DTVEPSTAAD IGGLWATIRG SSLEGVSLVL
FGSYSCAINV TTSNSSRIQC KVPPRGKDGH VVNVTVIRGN HSAVLPRAFT YVSSLNPVIV
TLSRNTSNIA GGETLVIGVA RLVNYTDLDV EVHIQDALAL VHTQSAWGLE VALPALPAGL
HRISVSINGI SIHSQGVDLH IQYLTEVFSI EPCCGSLLGG TILSISGIGF SRDPALVWVL
VGNRSCDIVN LTEASIWCET LPAPQIPDAG APTVPAAVEV WAGNRSFAHG PSPSLVGNGF
TFMYEAAATP VVTAMQGEIT NSSLSLRVGG SNLSNSVILL GNLNCDAETQ SFQGNSSLSG
CSVPLHSLEA GIYPLQVRQK QMGFANMSAV PQQFAVTPRI MAIFPSQGSA CGGTILTVRG
LLLNSRTRSV RVDLSGPFTC EILSLGDHTI LCQVSLEGDP LPGASFSLNV TVLVNGITSE
CHGNCTLFIR EEASPVMDTL STNTSGSLTT VLIRGERLGT TADEPMVFVD DQLLCNVTFF
NASHVVCQTR DLAPGPHYLS VFYTRNGYAC SGNVSRHFYI MPQVFHYFPK NFSIHGGSLL
TIEGTGLRGQ NTTSVYIDQQ ACLMVNIGAE LIRCIVPTGN GSAALEIEVD GPRYHIGVIG
YSNAFTPELI SISQSDGILT FAVAQISGAA NIDIFIGMSP CVGVSGNHTV LQCVVPSLPA
GEYHVRGYDC IRGWASSVLV FTSRVIITAV KENFGCLGGR LVHVFGAGFS PGNVSAAVCG
APCRVLANAT VSAFSCLVLP LDVSLAFLCG LKHEEDSCEA ARHTYVQCDL TVAVGTERML
ESWPYLYICE ESSQCLFVPD HWAESMFPSF SGLFVSPKVE RDEVLIYNSS CNITMETEAE
MECETPNQPI TVKITEIRKR WGQNTQGNFS LQFCRRWSRT HSWFPERLPQ DGDNVTVENG
QSLLLDTNTS VLNLLLIKGG KLIFMAPGPI ELRAHAILVS DGGELRIGSE DKPFQGRAQI
TLYGSSHSTP FFPYGVKFLA VRNGTLSLHG SLPEVIVTRL RATAHARDTV LALEDAVDWH
PGDEVVIISG TGVEGAKPME EIVTVETVQD TDVYLKSPLR YSHNFTENWV AGEHHILKAT
VALLSRSITI QGNLTNEREK LLLSCQEANA PEGNLQHCLY SMSEKMLGSR DMGARVIIQS
FPEEPSQVQL KGVQFQVLGQ AFHKHLSSLT LVGAMRESFI QGCTVRSSFS RGLSMCGTLG
LKVDSNVFYN ILGHALLVGT CMEMRYISWE AIHGRKYDWS GHGNIIRNNV IIQVSGAEGL
SNPEMLTPSG IYIRSPTNVI EGNRVWGAGY GYFFHLVTNQ TSQAPLLSFT QNIAHSCTRY
GLFVYPKFQP PWDNVTGITL FQSFTVWESA GGAQIFRSSN LRLKNFQVYS CRDFGIDILE
SDANTSVTDS LLLGHFAHKG SLCMSSGIKT PKRWELMVSN TTFVNFDLIN CVAIRTCSDC
FQGQGGFTVK TSQLKFINSS NLVAFPFPHA AILEDLDGSL SGKNRSHILA SMETLSASCL
VNASFGRVVH GSACGGGVLF HRMSIGLANA PEVSYDLTMT DSRNKTTTVN YVRDTLSNPH
GWMALLLDQE TYSLRSENLW INRSLQYSAT FDNFAPGNYL LLVHTDLPPY PDILLRCGSR
VGLSFPFLPS PGQNQGCDWF FNSQLRQLTY LVSGEGRVRV ILWVKEGMPP TISASTSAPE
SALKWSLPET WQGVEEGWGG YNNSLPGPGD DVLILPNRTV LVDTDLPFFK GLYVMGTLDF
PVDRSNVLSV ACMVIAGGEL KVGTLENPLE KEQKLLILLR ASEGVFCDRL NGIHIDPGTI
GVYGKVQLYS AYSKNSWTHL GADIASGNER IIVEDAVDWR PHDKIVLSSS SYEPHEAEVL
TVKEVKGHHV RIHERLKHRH IGSVHVTEDG RHIRLAAEVG LLTRNIQIQP DVSCRGRLFV
GPLRKSSREE FSGVLQLLNV EIQNFGSPLY SSVEFSNVSE GSWIISSTLH QSCGGGIHAT
ASHGVLLNDN IVFGTAGHGI DLEGQAYTVT NNLVVLMTQP AWSTIWVAGI KVNQAKDINL
HGNVVAGSER IGFHIRGHKC SCGLLWSDNV AHSSLHGLHL YKESGLDNCT RISGFLAFKN
FDYGAMLHIE NSVEIENITL VDNTIGLLAV VYVFSAPQNS IKKVQIVLRN SIIVATSSSF
DCIQDKVKPL SANLTSTDRA PSNPRGGRIG ILWPVFTSEP NQWPQEPWHK VRNDHSISGI
MKLQDVTFSS FVKSCYSDDL DVCILPNAEN TGIMHPITAE RTRMLKIKDK NKFYFPSLQP
RKDLGKVVCP ELDCASPRKY LFKDLDGRAL GLPPPVSIFP KTEAEWTTSF FNAGTYREEQ
KCTYRFLMQG FVCKQTDQVV LILDGADATW AIQKLYPVVS VTSGFVDIFS SVNANIPCST
SGSVSTFYSI LPTRQITKVC FMDQTPQVLR FFLLGNKSTS KLLLAVFYHE LQNPHVFLGE
SFIPPTLVQS ASLLLNESIG ANYFNIMDNL LYVVLQGEEP IEIRSSVSIN LALTVMVSVL
EKGWEIVILE RLTNFLQIGQ NQIRFLREIP GHEETLKAIA DSRAKRKRNC PTVTCASHYR
RVSQRRPLMM EMNSYRSSPP TTVETMSKVI VIEIGDSPTV RSTGMISSLS SNKLQNLAHQ
VITAQQTGVL ENILNMTIGA LLVTQSKGVI GYGNSSSFKT GNLIYIRPYV LSVLVQPSDG
EVGNELPVQP QLVFLDEQNR RVESLGPPSE PWTISASLEG ASDSVLKGVN FTARSQSFAV
LPVTRKEKST IILAASLSSV ASWLALSCLV CCWLKRSKSR KTKPEEIPES QTNNENNHIH
TSSKCRESQG PKKEDTVVAE DMRMKVMLGR LNQCPHQLMN GVSRRKVSRH IVREEEAAVP
APGTTGITSH EHTCAPGAPA QQVYLQETGN WKEGQEQLLR YQLAGQDQLL LQERQQLPGQ
SWLSKQSGSL GLSQEKKASC GATEAFCLHS VHLEAIQEQL
//