ID A0A2K6AF51_MANLE Unreviewed; 1007 AA.
AC A0A2K6AF51;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=DENN domain containing 1A {ECO:0000313|Ensembl:ENSMLEP00000038691.1};
GN Name=DENND1A {ECO:0000313|Ensembl:ENSMLEP00000038691.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000038691.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000038691.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6AF51; -.
DR STRING; 9568.ENSMLEP00000038691; -.
DR Ensembl; ENSMLET00000062304.1; ENSMLEP00000038691.1; ENSMLEG00000043396.1.
DR GeneTree; ENSGT00940000156261; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0032456; P:endocytic recycling; IEA:Ensembl.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; IEA:Ensembl.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 6.10.140.1000; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR040032; DENND1A/B/C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13196; DENN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR13196:SF22; DENN DOMAIN-CONTAINING PROTEIN 1A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 7..372
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 447..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..955
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 110380 MW; 51E04CF2349CBC2C CRC64;
QNPETTFEVY VEVAYPRTGG TLSDPEVQRQ FPEDYSDQEV LQTLTKFCFP FYMDSLTVSQ
VGQNFTFVLT DIDSKQRFGF CRLSSGAKSC FCILSYLPWF EVFYKLLNIL ADYTTKRQEN
QWNELLETLH KLPIPDPGVS VHLSVHSYFT VPDTRELPSI PENRNLTEYF VAVDVNNMLH
LYASMLYERR ILIICSKLST LTACIHGSAA MLYPMYWQHV YIPVLPPHLL DYCCAPMPYL
IGIHLSLMEK VRNMALDDVV ILNVDTNTLE TPFDDLQSLP NDVISSLKNR LKKVSTTTGD
GVARAFLKAQ AAFFGSYRNA LKIEPEEPIT FCEEAFVSHY RSGAMRQFLQ NATQLQLFKQ
FIDGRLDLLN SGEGFSDVFE EEINMGEYAG SDKLYHQWLS TVRKGSGAIL NTVKTKANPA
MKTVYKFAKD HAKMGIKEVK NRLKQKDIAE NGCAPTPEEQ LPKTAPSPLV EAKDPKLRED
RRPITVHFGQ VRPPRPHVVK RPKSNITVEG RRTSVPSPEQ PQPYRTLKES DSAEGDEAES
PEQQVRKPAG PVPAPTDRAA SIDLLEDVFN NLDMEAALQP LGQAKSLEDL RAPKDLREQP
GTFDYQRLDL GGSERSRGVT VALKLTHPYN KLWSLGQDDM AIPSKPPAAS PEKPSALLGN
SLALPRRPQN RDSILNPSDK EEVPTPTLGS ITIPRPQGRK TPELGIVPPP PIPRPAKLQA
AGAALGDVSE RLQVDRDRRA ALSPGLLPGG VPQGPTELLQ PLSPSPGAAG TSSDALLALL
DPLSTAWSGS TLPPRHATPN VATPFTPQFS FPPAGTPAPF PQPPLNPFVP SMPAAPPTLS
LVSTPAGPFG VPPASLGPAF ASGLLLSSAG FCAPHRSQPN LSALSMPNLF GQMPMGTHTS
PLQPLGPPAV APSRIRTLPL ARSSARAAEA KQGLALRPAD PPLLPPRPPQ GLEPTLRPSA
PQQTRDPFED LLQKTKQDVS PSPVLAPAPA PAPDSVEQLR KQWETFE
//