ID A0A2K6AH06_MANLE Unreviewed; 662 AA.
AC A0A2K6AH06;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=E74 like ETS transcription factor 4 {ECO:0000313|Ensembl:ENSMLEP00000039313.1};
GN Name=ELF4 {ECO:0000313|Ensembl:ENSMLEP00000039313.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000039313.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000039313.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_011844230.1; XM_011988840.1.
DR AlphaFoldDB; A0A2K6AH06; -.
DR STRING; 9568.ENSMLEP00000039313; -.
DR Ensembl; ENSMLET00000062929.1; ENSMLEP00000039313.1; ENSMLEG00000043693.1.
DR GeneID; 105545800; -.
DR KEGG; mleu:105545800; -.
DR CTD; 2000; -.
DR GeneTree; ENSGT00940000161870; -.
DR OMA; DDQEGHC; -.
DR OrthoDB; 4245771at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001787; P:natural killer cell proliferation; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0001866; P:NK T cell proliferation; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR022084; TF_Elf_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF170; ETS-RELATED TRANSCRIPTION FACTOR ELF-4; 1.
DR Pfam; PF12310; Elf-1_N; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 208..290
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 139..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 70718 MW; FED973C3D9003942 CRC64;
MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS GLELDDHNGI
ITDGTLCMTQ DQILEGSFLL TDDNEATSHT MSTTEVLLNM ESPSDILDEK QIFNTSEMLP
DSDPAPAVTL PNYLFPASEP DALNRAGDTS DQEGHSLEEK ASREESAKKT GKSKKRIRKT
KGNRSTSPVT DPSIPIRKKS KDGKGSTIYL WEFLLALLQD RNTCPKYIKW TQREKGIFKL
VDSKAVSKLW GKQKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLVVIE
DEDESSEATA APPQASTASV ASASTTRRTS SRVSSRSAPQ VKGSSSWEKP KIQHVGLQPS
ASLELGLSLD EEIPTTSTML VSPAEGQVKL TKAVSATSVP SNIHLGVAPV GSGSALTLQT
IPLTTVLTNG PPANTTAPTQ LVLQSVPAAS TFKDTFTLQA SFPLNASFQD SQVAAPGAPL
ILSGLPQLLA GANRPTNPAP PTVTGAGPAG PSSQPPGTVI AAFIRTSGTT AAPGVKEGPL
RPSSYVQGMV TGAPMEGLLV PEETLRELLR DQAHLQPLPT QVVSRGSHNP SLLGNQTLPP
PSRPTVGLTP VAELELSSGP GSLLMAEPSV TTSGSLLTRS PTPAPFSPFN PTSLIKMEPH
DI
//