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Database: UniProt
Entry: A0A2K6AH06_MANLE
LinkDB: A0A2K6AH06_MANLE
Original site: A0A2K6AH06_MANLE 
ID   A0A2K6AH06_MANLE        Unreviewed;       662 AA.
AC   A0A2K6AH06;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=E74 like ETS transcription factor 4 {ECO:0000313|Ensembl:ENSMLEP00000039313.1};
GN   Name=ELF4 {ECO:0000313|Ensembl:ENSMLEP00000039313.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000039313.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000039313.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC       ECO:0000256|RuleBase:RU004019}.
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DR   RefSeq; XP_011844230.1; XM_011988840.1.
DR   AlphaFoldDB; A0A2K6AH06; -.
DR   STRING; 9568.ENSMLEP00000039313; -.
DR   Ensembl; ENSMLET00000062929.1; ENSMLEP00000039313.1; ENSMLEG00000043693.1.
DR   GeneID; 105545800; -.
DR   KEGG; mleu:105545800; -.
DR   CTD; 2000; -.
DR   GeneTree; ENSGT00940000161870; -.
DR   OMA; DDQEGHC; -.
DR   OrthoDB; 4245771at2759; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0016605; C:PML body; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001787; P:natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:0001866; P:NK T cell proliferation; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR022084; TF_Elf_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; ETS; 1.
DR   PANTHER; PTHR11849:SF170; ETS-RELATED TRANSCRIPTION FACTOR ELF-4; 1.
DR   Pfam; PF12310; Elf-1_N; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW   Nucleus {ECO:0000256|RuleBase:RU004019};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          208..290
FT                   /note="ETS"
FT                   /evidence="ECO:0000259|PROSITE:PS50061"
FT   REGION          139..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          492..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        582..602
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  70718 MW;  FED973C3D9003942 CRC64;
     MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS GLELDDHNGI
     ITDGTLCMTQ DQILEGSFLL TDDNEATSHT MSTTEVLLNM ESPSDILDEK QIFNTSEMLP
     DSDPAPAVTL PNYLFPASEP DALNRAGDTS DQEGHSLEEK ASREESAKKT GKSKKRIRKT
     KGNRSTSPVT DPSIPIRKKS KDGKGSTIYL WEFLLALLQD RNTCPKYIKW TQREKGIFKL
     VDSKAVSKLW GKQKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLVVIE
     DEDESSEATA APPQASTASV ASASTTRRTS SRVSSRSAPQ VKGSSSWEKP KIQHVGLQPS
     ASLELGLSLD EEIPTTSTML VSPAEGQVKL TKAVSATSVP SNIHLGVAPV GSGSALTLQT
     IPLTTVLTNG PPANTTAPTQ LVLQSVPAAS TFKDTFTLQA SFPLNASFQD SQVAAPGAPL
     ILSGLPQLLA GANRPTNPAP PTVTGAGPAG PSSQPPGTVI AAFIRTSGTT AAPGVKEGPL
     RPSSYVQGMV TGAPMEGLLV PEETLRELLR DQAHLQPLPT QVVSRGSHNP SLLGNQTLPP
     PSRPTVGLTP VAELELSSGP GSLLMAEPSV TTSGSLLTRS PTPAPFSPFN PTSLIKMEPH
     DI
//
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