ID A0A2K6AHX4_MANLE Unreviewed; 1553 AA.
AC A0A2K6AHX4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Dynamin-binding protein {ECO:0000256|ARBA:ARBA00018186};
DE AltName: Full=Scaffold protein Tuba {ECO:0000256|ARBA:ARBA00032587};
GN Name=DNMBP {ECO:0000313|Ensembl:ENSMLEP00000039651.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000039651.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000039651.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi apparatus, Golgi stack
CC {ECO:0000256|ARBA:ARBA00004348}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR Ensembl; ENSMLET00000063269.1; ENSMLEP00000039651.1; ENSMLEG00000043828.1.
DR GeneTree; ENSGT00950000183088; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07589; BAR_DNMBP; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11798; SH3_DNMBP_C1; 1.
DR CDD; cd12141; SH3_DNMBP_C2; 1.
DR CDD; cd11795; SH3_DNMBP_N2; 1.
DR CDD; cd11796; SH3_DNMBP_N3; 1.
DR CDD; cd11797; SH3_DNMBP_N4; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 6.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035820; DNMBP_SH3_C1.
DR InterPro; IPR035818; DNMBP_SH3_N2.
DR InterPro; IPR035819; DNMBP_SH3_N3.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22834:SF19; DYNAMIN-BINDING PROTEIN; 1.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00499; P67PHOX.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 6.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50044; SH3-domain; 6.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 6.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..37
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 42..102
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 121..180
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 219..278
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 760..943
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 984..1193
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 1261..1324
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1489..1552
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 187..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1324..1462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 674..731
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 566..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1328..1423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1553 AA; 173958 MW; E61235C9029D80D0 CRC64;
VGDVIEVLAV VDEFWLLGKK EDVTGQFPSS FVEIVTIPSL KEGERLFVCI CEFTSQELDS
LPLHRGDLVI LDGVPTAGWL QGRSCWGARG FFPSSCVREL CLSSQSRQWH SQSALFQIPE
YSMGQARALM GLSAQLDEEL DFREGDVITI IGVPEPGWFE GELEGRRGIF PEGFVELLGP
LRTVDESVSS GNPDDCIVNG EVDTPVGEEE TGPDEDEEEP GTYGVALYRF QALEPNELDF
EVGDKIRILA TLEDGWLEGS LKGRTGIFPY RFVKLHPDTQ VEETMALPQE GSLSRIPETS
LDCLENSLGV EEQRHETSDH VAEEPDCIIS EAPTSPLGHL TSEYEADRNS YQDEGTAAGP
RRSPGVEWEM PLATDSPTSD PTEVVNGISS QPQVPFHPSL QRSQYYSTAG GSHPHSDQHP
DLLPLEARNR DYASLPPKRM HSQLKTLQKP VLPLYRGSSL SASGVVKPSQ SSPQLHDIAS
YAKKHHTSSV YSVSERSEMK PGPQAQGLVM EAATHSQGDG STDLDSKLTQ QLIEFEKSLA
GPGTEPDKIL RHFSITDFNS EKDIVRGSSK LITEQELPER RKALRPPPPR PCTPVSASPH
LLVDQNLKPA PPLVVRPSRP APLPPSAQQR TNAVSPKLLS RHHPTCETLE KEGHGHMGRS
LDQTSPCPLV LVRIEEMEQD LDMYSRAQEE LNLMLEEKQD ESSRAETLKD LKFCESNIES
LNMELQQLRE MTLLSSQSSS LVAPSGSVST ENPEQRMLEK RAKVVEELLQ TERDYIRDLE
MCIERIMVPL QQAQVANIDF EGLFGNMQMV IKVSKQLLAA LEISDAVGPV FLGHRDELEG
TYKIYCQNHD EAIALLEIYE KDEKIQKHLQ DSLADLKSLY NEWGCTNYIN LGSFLIKPVQ
RVMRYPLLLM ELLNSTPESH PDKVPLTNAV LAVKEINVNI NEYKRRKDLV LKYRKGDEDS
LMEKISKLNI HSIIKKSNRV SSHLKHLTGF APQIKDEVFE ETEKNFRMQE RLIKSFIRDL
SLYLQHIRES ACVKVVAAVS MWDVCMERGH RDLEQFEKVH RYISDQLFTN FKERTERLVI
SPLNQLLSMF TGPHKLVQKR FDKLLDFYNC TERAEKLKDK KTLEELQSAR NNYEALNAQL
LDELPKFHQY AQGLFTNCVH GYAEAHCDFV HQALEQLKPL LSLLKVAGRE GNLIAIFHEE
HSRVLQQLQV FTFFPESLPA PKKPFERKTV DRQSARKSLV GLPSYMLQSE ELRASLLARY
PPEKLFQAER NFNAAQDLDV SLLEGDLVGV IKKKDPMGSQ NRWLIDNGVT KGFVYSSFLK
PYNPRRSHSD ASVGSHSSTE SEHGSSSPRF PRQNSGSTLT FNPSSMAVSF TSGSCQKQPQ
DISSPLKEGD QGTLSASLNP GSSESGPSGC PSEPDSTSQP RSGDAPDVAR DVNQPTATPR
SYRNFRHPEM VGYSVPGRNG QGQDLVKGCA RTAQAPEDRS AEPESSEAEG NQVYFAVYTF
KARNPNELSV SANQKLKILE FKDVTGNTEW WLAEVNGKKG YVPSNYIRKT EYT
//
