ID   A0A2K6AI14_MANLE        Unreviewed;       349 AA.
AC   A0A2K6AI14;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Ion channel TACAN {ECO:0000256|ARBA:ARBA00039635};
DE   AltName: Full=Transmembrane protein 120A {ECO:0000256|ARBA:ARBA00041456};
GN   Name=TMEM120A {ECO:0000313|Ensembl:ENSMLEP00000039699.1};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000039699.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000039699.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Nucleus inner membrane
CC       {ECO:0000256|ARBA:ARBA00004473}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004473}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family.
CC       {ECO:0000256|ARBA:ARBA00009700}.
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DR   AlphaFoldDB; A0A2K6AI14; -.
DR   Ensembl; ENSMLET00000063318.1; ENSMLEP00000039699.1; ENSMLEG00000043854.1.
DR   GeneTree; ENSGT00390000007848; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433:SF1; ION CHANNEL TACAN; 1.
DR   PANTHER; PTHR21433; TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        136..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        167..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   349 AA;  41129 MW;  6CB6B39A5DCC46FA CRC64;
     MQPPPPGPLG DCLRDWEDLQ QDFQNIQETH RLYRLKLEEL TKLQNNCTSS ITRQKKRLQE
     LALTLKKCKP SLPAEAEGAA QELENQMKER QGLFFDMEAY LPKKNGLYLS LVLGNVNVTL
     LSKQAKFAYK DEYEKFKLYL TIILILISFT CRFLLNSRVT DATFNFLLVW YYCTLTIRES
     ILINNGSRIK GWWVFHHYVS TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY
     QSGCLYRLRA LGERHTMDLT VEGFQSWMWR GLTFLRASVS LPVCLSSAPF WQLFNALTLF
     NLARDPQCKE WQVLMCGFPF LLLFLGNFFT TLRVVHQKFH SQWHGSKKD
//