ID   A0A2K6AJ47_MANLE        Unreviewed;      1086 AA.
AC   A0A2K6AJ47;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Structural maintenance of chromosomes protein 5 {ECO:0000256|ARBA:ARBA00018687};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000040058.1, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000040058.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the SMC family. SMC5 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010171}.
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DR   AlphaFoldDB; A0A2K6AJ47; -.
DR   Ensembl; ENSMLET00000063681.1; ENSMLEP00000040058.1; ENSMLEG00000044051.1.
DR   GeneTree; ENSGT01100000263667; -.
DR   OMA; RFWTSQP; -.
DR   Proteomes; UP000233140; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR027131; SMC5.
DR   PANTHER; PTHR45916; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR   PANTHER; PTHR45916:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT   DOMAIN          53..1038
FT                   /note="RecF/RecN/SMC N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02463"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          236..434
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          652..748
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          875..912
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1086 AA;  127469 MW;  948D28DF53C20FF8 CRC64;
     MATPSKKTST PSPQASKRAL PRDPSSEVPS KRKNPAPQLP LVQSSGPFVE GSIVRISMEN
     FLTYDICEVS PGPHLNMIIG ANGTGKSSIV CAICLGLAGK PAFMGRADKV GFFVKRGCSR
     GMVEIELFRA SGNLVITREI DVAKNQSFWF INKKSTTQKV VEEQVAALNI QVGNLCQFLP
     QDKVGEFAKL SKIELLEATE KSIGPPEMHR YHCELKNFRE KEKQLETSCK EKTEYLQKMV
     QRNERYKQDV ERFYERKRHL DLIEMLEAKR PWVEYENVRQ EYEEVKLVRD RVKEEVRKLK
     EGQIPITRRI EEMENERHNL EARIKEKATD IKEASQKCKQ KQDVIERKDK HIEEIQQALT
     VKQNEELDRQ RRISNTRKMI EDLQNELKTT ENCENLQPQI DAITNDLRRI QDEKALCEGE
     IIDKRRERET LEKEKKSVDD HIVRFDNLMN QKEDKLRQRF RDTYDAVLWL RSNRDKFKQR
     VCEPIMLTIN MKDNKNAKYI ENHIPSNDLR AFVFESQEDM EVFLKEVRDN KKLRVNAVIA
     PRSSYADKAP SRSLNELKQY GFFSYLRELF DAPDPVMSYL CCQYHIHEVP VGTEKTRERI
     ERVIQETRLK QIYTAEEKYV VKTSFYSNKI ISSNTSLKVA QFLTVTVDLE QRRHLEEQLK
     EISRKLQAVD SRLIALRETS KHLEHKDNEL RQKKKELLER KTKKRQLEQK ISSKLGSLKL
     MEQDTCNLEE EERKASTKIK EINVQKAKLV TELTNLIKIC TSLHIQKVDL ILQNTTVISE
     KNKLESDYMA ASSQLRLTEQ HFIELDENRQ RLLQKCKELM KRARQVCNLG AEQTLPQEYQ
     TVFQDLPNTL DEIDALLTEE RSRASCFTGL NPTIVQEYTK REEEIEQLTE ELKGKKVELD
     QYRENISQVK ERWLNPLKEL VEKINEKFSN FFSSMQCAGE VDLHTENEED YDKYGIRIRV
     KFRSSTQLHE LTPHHQSGGE RSVSTMLYLM ALQELNRCPF RVVDEINQGM DPINERRVFE
     MVVNTACKEN TSQYFFITPK LLQNLPYSEK MTVLFVYNGP HMLEPNRWNL KAFQRRRRRI
     TFTQPS
//