ID A0A2K6AJF3_MANLE Unreviewed; 1538 AA.
AC A0A2K6AJF3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Kielin cysteine rich BMP regulator {ECO:0000313|Ensembl:ENSMLEP00000040145.1};
GN Name=KCP {ECO:0000313|Ensembl:ENSMLEP00000040145.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000040145.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000040145.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9568.ENSMLEP00000040145; -.
DR Ensembl; ENSMLET00000063769.1; ENSMLEP00000040145.1; ENSMLEG00000044089.1.
DR GeneTree; ENSGT00940000160243; -.
DR OMA; CQECVVE; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR CDD; cd19941; TIL; 1.
DR Gene3D; 6.20.200.20; -; 14.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 4.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR46698; CROSSVEINLESS 2; 1.
DR PANTHER; PTHR46698:SF4; CROSSVEINLESS 2; 1.
DR Pfam; PF00093; VWC; 11.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00832; C8; 1.
DR SMART; SM00214; VWC; 19.
DR SMART; SM00215; VWC_out; 11.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57603; FnI-like domain; 19.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR PROSITE; PS01208; VWFC_1; 9.
DR PROSITE; PS50184; VWFC_2; 15.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 110..163
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 164..223
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 223..282
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 282..340
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 396..455
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 455..514
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 572..631
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 631..688
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 688..747
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 806..865
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 865..923
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 923..991
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 988..1051
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1051..1115
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1119..1179
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1183..1359
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1519..1538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 34..61
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1538 AA; 164450 MW; 30576767A7BEAE17 CRC64;
GTVPKEPPGQ QTPVHSSAPA GDPQEQWLPL REWLGRLEAA VVELREQNKD LQMRVRRLES
CECHPASPQC WGLGRAWPEG ARWEPDPCTA CVCQDGTAHC GPQAHLPHCR GCSQNGQTYG
NGETFSPDAC TTCRCLEGTI SCTPKPCPRG PCPEPGACCP HCEPGCEYEG QLYEEGSTFL
SSSNPCLQCT CLRSRARCMS LKCPPSPCPQ PVLRPGHCCP TCQGCTEGGS HWEHGQEWTT
PGDPCRICQC LEGHIQCRQR ECASLCPYPA RPLPGTCCPV CDGCFLNGRE HRSGEPVGSG
DPCSHCRCAN GSVQCEPLPC PPVPCRHPGK IPGQCCPVCD GCEYQGHQYQ SQETFRLQER
GLCVRCSCQA GEVSCEEQEC PVTPCALPAS GRQLCPACVL DGEEFAEGVQ WEPDGRPCTT
CVCQDGVPKC GAALCTPAPC QHPTQPPGAC CPSCDSCTYH GQVYANGQNF TDADSPCHVC
RCQDGTVTCS LVDCPLTTCA RPQSGPGQCC PRCPDCILEE EVFVDGESFS HPRDPCQECR
CQEGHARCQP RACLRAPCAH PLPGTCCRND CSGCAFGGKE YASGADFPHP SDPCRLCRCL
SGNVQCLTRR CSPLPCPEPV LLPGDCCPQC PGCLYQGKEF ASGERFPSTT AACHLCLCWE
GSVSCEPKAC APALCPFPAR GDCCPDCDGC EYLGESYLSN QEFPDPREPC NLCTCLGGFV
TCGHRPCEPP GCSHPFIPSG HCCPTCQGCH YHGVTAASGE TLPDPLDPAC SLCTCQEGSM
RCQKKPCPPA LCPHPSPGPC FCPVCHSCVS QGREHQDGEE FEGAAGSCEW CRCQAGQVRC
VRLQCPPLPC QLQVTEPGSC CPRCRGCLVH GEEHPEGSSW VPPDSACSSC VCHEGVITCA
RVQCISSCAQ PHQGPHDCCP RCSDCEHEGR KYEPGESFQP GADPCEVCIC QPQPEGPPSL
RCHRRQCPSL VGCPPSQLLP PGPQHCCPTC AQALSNCSEG LLGSELAPPD PCYTCQCQDL
TWLCIHQTCP ELSCPLSERH TPPGSCCPVC QECVVEAEGR RVADGESWRD PSNACITCTC
RRGHVECHLE ECQALSCPHG WAKVPQADSC CERCQAPTQS CVHQGREVAS GERWTVDACT
SCSCMAGTVR CQSRRCSPLS CGPDKAPALS PGSCCPRCLP RPASCMAFGD PHYRTFDGRL
LHFQGSCSYV LAKDCHSGDF SVHVTNDDRG RSGVAWTQEV AVLLGDVAVR LLQGGAVTVD
GHPVALPFLQ EPLLYVELRG HTVILHTQPG LQVLWDGQSQ VEVSVPGSYQ GRTCGLCGNF
NGFAQDDLQG PEGLLLPTEA AFGNSWQVPE GLGPGRPCSA GREMDPCRAA GYRARREANA
RCGVLKSSPF SRCHAVVPPE PFFAACVYDL CACGPGSSAD ACLCDALEAY ASHCRQAGVT
PTWRGPTLCV VGCPLEHGFV FDECGPPCPR TCFNQHIPLG ELAAHCVRPC MPGCQCPAGL
VEHEAHCIPP EACPQVLLTG DQPLGAPPSP SREPQETP
//
