ID A0A2K6ALF1_MANLE Unreviewed; 2783 AA.
AC A0A2K6ALF1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Neurofibromin 1 {ECO:0000313|Ensembl:ENSMLEP00000040835.1};
GN Name=NF1 {ECO:0000313|Ensembl:ENSMLEP00000040835.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000040835.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000040835.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSMLET00000064463.1; ENSMLEP00000040835.1; ENSMLEG00000044436.1.
DR GeneTree; ENSGT00550000074797; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140}.
FT DOMAIN 1179..1395
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1524..1682
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2731..2783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2746..2775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2783 AA; 313094 MW; 801725B7A09B58A0 CRC64;
MCRIFGEAAE KNLYLSQLII LDTLEKCLAG QPKDTMRLDE TMLVKQLLPE ICHFLHTCRE
GNQHAAELRN SASGVLFSLS CNNFNAVFSR ISTRLQELTV CSEDNVDVHD IELLQYINVD
CAKLKRLLKE TAFKFKALKK VAQLAVINSL EKAFWNWVEN YPDEFTKLYQ IPQTDMAECA
EKLFDLVDGF AESTKRKAAV WPLQIILLIL CPEIIQDISK DVVDENNMNK KLFLDSLRKA
LAGHGGSRQL TESAAISCVK LCKASTYINW EDNSVIFLLV QSMVVDLKNL LFNPSKPFSR
GSQPADVDLM IDCLVSCFRI SPHNNQHFKI CLAQNSPSTF HYVLVNSLHR IITNSTFKHG
LGTASALDWW PKIDAVYCHS VELRNMFGET LHKAVQGCGA HPAIRMAQTL TFKEKVTSLK
FKEKPTDLET RSYKYLLLSM VKLIHADPKL LLCNPRKQGP ETQGSTAELI TGLVQLVPQS
HMPEIAQEAM EALLVLHQLD SIDLWNPDAP VETFWEISSQ MLFYICKKLT SHQMLSSTEI
LKWLREILIC RNKFLLKNKQ ADRSSCHFLL FYGVGCDIPS SGNTSQMSID HEELLHTPRD
SLQKGKGNSS MDSAAGCSGT PPICRQAQTK LEVALYMFLW NPDTEAVLVA MSCFRHLCEE
ADIRCGVDEV SVHNLLPNYN TFMEFASVSN MMSTGRAALQ KRVMALLRRI EHPTAGNTEA
WEDTHAKWEQ ATKLILNYPK AKMEDGQAAE SLHKTIVKRR MSHVSGGGSI DLSDTDSLQE
WINMTGFLCA LGGVCLQQRS NSGLATYSPP MGPVNERKGS MISVMSSEGN ADTPVSKFMD
RLLSLMVCNH EKVGLQIRTN VKDLVGLELS PALYPMLFNK LKNTISKFFD SQGQVLLTDT
NTQFVEQTIA IMKNLLDNHT EGSSEHLGQA SIETMMLNLV RYVRVLGNMV HAIQIKTKLC
QLVEVMMARR DDLSFCQEMK FRNKMVEYLT DWVMGTSNQA ADDDVKCLTR DLDQASMEAV
VSLLAGLPLQ PEEGDGVELM EAKSQLFLKY FTLFMNLLND CSEVEDENAQ TGGRKRGMSR
RLASLRHCTV LAMSNLLNAN VDSGLMHSIG LGYHKDLQTR ATFMEVLTKI LQQGTEFDTL
AETVLADRFE RLVELVTMMG DQGELPIAMA LANVVPCSQW DELARVLVTL FDSRHLLYQL
LWNMFSKEVE LADSMQTLFR GNSLASKIMT FCFKVYGATY LQKLLDPLLR IVITSSDWQH
VSFEVDPTRL EPSESLEENQ RNLLQMTEKF FHAIISSSSE FPPQLRSVCH CLYQATCHSL
LNKATVKEKK ENKKSVVSQR FPQNSIGAVG SAMFLRFINP AIVSPYEAGI LDKKPPPRIE
RGLKLMSKIL QSIANHVLFT KEEHMRPFND FVKTNFDAAR RFFLDIASDC PTSDAVNHSL
SFISDGNVLA LHRLLWNNQE KIGQYLSSNR DHKAVGRRPF DKMATLLAYL GPPEHKPVAD
THWSSLNLTS SKFEEFMTRH QVHEKEEFKA LKTLSIFYQA GTSKAGNPIF YYVARRFKTG
QINGDLLIYH VLLTLKPYYA KPYEIVVDLT HTGPSNRFKT DFLSKWFVVF PGFAYDNVSA
VYIYNCNSWV REYTKYHERL LTGLKGSKRL VFIDCPGKLA EHIEHEQQKL PAATLALEED
LKVFHNALKL AHKDTKVSIK VGSTAVQVTS AERTKVLGQS VFLNDIYYAS EIEEICLVDE
NQFTLTIANQ GTPLTFMHQE CEAIVQSIIH IRTRWELSQP DSIPQHTKIR PKDVPGTLLN
IALLNLGSSD PSLRSAAYNL LCALTCTFNL KIEGQLLETS GLCIPANNTL FIVSISKTLA
ANEPHLTLEF LEECISGFSK SSIELKHLCL EYMTPWLSNL VRFCKHNDDA KRQRVTAILD
KLITMTINEK QMYPSIQAKI WGSLGQITDL LDVVLDSFIK TSATGGLGSI KAEVMADTAV
ALASGNVKLV SSKVIGRMCK IIDKTCLSPT PTLEQHLMWD DIAILARYML MLSFNNSLDV
AAHLPYLFHV VTFLVATGPL SLRASTHGLV INIIHSLCTC SQLHFSEETK QVLRLSLTEF
SLPKFYLLFG ISKVKSAAVI AFRSSYRDRS FSPGSYERET FALTSLETVT EALLEIMEAC
MRDIPTCKWL DQWTELAQRF AFQYNPSLQP RALVVFGCIS KRVSHGQIKQ IIRILSKALE
SCLKGPDTYN SQVLIEATVI ALTKLQPLLN KDSPLHKALF WVAVAVLQLD EVNLYSAGTA
LLEQNLHTLD SLRIFNDKSP EEVFMAIRNP LEWHCKQMDH FVGLNFNSNF NFALVGHLLK
GYRHPSPAIV ARTVRILHTL LTLVNKHRNC DKFEVNTQSV AYLAALLTVS EEVRSRCSLK
HRKSLLLTDV SMENVPMDTY PIHHGDPTYR TLKETQPWSS PKGSEGYLAA TYPTVGQTSP
RARKSMSLDM GQPSQANTKK LLGTRKSFDH LISDTKAPKR QEMESGITTP PKMRRVAETD
YEMETQRISS SQQHPHLRKV SVSESNVLLD EEVLTDPKIQ ALLLTVLATL VKYTTDEFDQ
RILYEYLAEA SVVFPKVFPV VHNLLDSKIN TLLSLCQDPN LLNPIHGIVQ SVVYHEESPP
QYQTSYLQSF GFNGLWRFAG PFSKQTQIPD YAELIVKFLD ALIDTYLPGI DEETSEESLL
TPTSPYPPAL QSQLSITANL NLSNSMTSLA TSQHSPGIDK ENVELSPTTG HCNSGRTRHG
SASQVQKQRS AGSFKRNSIK KIV
//
