ID A0A2K6ALJ4_MANLE Unreviewed; 740 AA.
AC A0A2K6ALJ4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Semaphorin 3A {ECO:0000313|Ensembl:ENSMLEP00000040875.1};
GN Name=SEMA3A {ECO:0000313|Ensembl:ENSMLEP00000040875.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000040875.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000040875.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A2K6ALJ4; -.
DR STRING; 9568.ENSMLEP00000040875; -.
DR Ensembl; ENSMLET00000064503.1; ENSMLEP00000040875.1; ENSMLEG00000044454.1.
DR GeneTree; ENSGT00940000158203; -.
DR OMA; RXKECAN; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0021772; P:olfactory bulb development; IEA:Ensembl.
DR GO; GO:0048841; P:regulation of axon extension involved in axon guidance; IEA:Ensembl.
DR CDD; cd05871; Ig_Sema3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR041416; IL-1RAcP-like_ig.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF23; SEMAPHORIN-3A; 1.
DR Pfam; PF18452; Ig_6; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..740
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014336151"
FT DOMAIN 31..482
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 549..633
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 697..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 85668 MW; EA5F32E29F8F5134 CRC64;
MGWLTRIVCL FWGVLLTARA NYQNGKNNVP RLKLSYKEML ESNNVITFNG LANSSSYHTF
LLDEERSRLY VGAKDHIFSF NLVNIKDFQK IVWPVSYTRR DECKWAGKDI LKECANFIKV
LKAYNQTHLY ACGTGAFHPI CTYIEIGHHP EDNIFKLENS HFENGRGKSP YDPKLLTASL
LIDGELYSGT AADFMGRDFA IFRTLGHHHP IRTEQHDSRW LNGTWFMKEN RHITYVTVLS
THHHAQLLFN DFGGHRSLVN KWTTFLKARL ICSVPGPNGI DTHFDELQDV FLMNFKDPKN
PIVYGVFTTS SNIFKGSAVC MYSMSDVRRV FLGPYAHRDG PNYQWVPYQG RVPYPRPGTC
PSKTFGGFDS TKDLPDDVIT FARSHPAMYN PVFPINNRPI MIKTDVNYQF TQIVVDRVDA
EDGQYDVMFI GTDVGTVLKV VSIPKETWHD LEEVLLEEMT VFRVSAQQLY IGSTAGVAQL
PLHRCDIYGK ACAECCLARD PYCAWDGSSC SRYFPTAKRR TRRQDIRNGD PLTHCSDLQH
HDNHHGHSPE ERIIYGVENS STFLECSPKS QQALVYWQFQ RRNEERKEEI RVDDHIIRTD
QGLLLRSLQR KDSGNYLCHA VEHGFIQTLL KVTLEVIDTE HLEELLHKDD DGDGSKTKEM
SNSMTPSQKV WYRDFMQLIN HPNLNTMDEF CEQVWKRDRK QRRQRPGHTQ GNSNKWKHLQ
ENKKGRNRRT HEFERAPRSV
//
