ID A0A2K6AMX3_MACNE Unreviewed; 1618 AA.
AC A0A2K6AMX3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=ATP binding cassette subfamily A member 6 {ECO:0000313|Ensembl:ENSMNEP00000000510.1};
GN Name=ABCA6 {ECO:0000313|Ensembl:ENSMNEP00000000510.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000000510.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000000510.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_011717931.1; XM_011719629.1.
DR RefSeq; XP_011717932.1; XM_011719630.1.
DR STRING; 9545.ENSMNEP00000000510; -.
DR Ensembl; ENSMNET00000002639.1; ENSMNEP00000000510.1; ENSMNEG00000002396.1.
DR GeneID; 105469060; -.
DR KEGG; mni:105469060; -.
DR CTD; 23460; -.
DR GeneTree; ENSGT00940000162244; -.
DR OMA; ITSQIVF; -.
DR OrthoDB; 6951at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000002396; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF13; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 6; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1019..1037
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1058..1083
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1095..1117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1129..1149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1155..1175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1196..1215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 479..714
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1289..1514
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1235..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1618 AA; 184326 MW; 34B28AFC8F6192B4 CRC64;
MNMKQKSVYQ QTKALLCKNF LKKWRMKRES LLEWGLSILL GLCIALFSSS MRNVQFPGMA
PQNLGRVDKF NSSSLKVVYT PISNLTQQIM NKTALAPLLK GTSVIGAPNK TYMNEILLEN
FPYAMGIIFN ETFSYKLTFF QGYSIPLWKE EDFSAHCWDG YGEFPCKLTK YWNRGFVALQ
TAINTAIIEI TTNHPVMEEL MSVTAITMKT LPFISKNLLH NEIFIFFFLL HFSPLVYFIS
LNVTKERKKS KNLMKVMGLQ DSAFWLSWGL IYAGFIFIIS IFITIVITFT EIIVMTGFMV
IFILFFLYGL SLVALVFLMS VLLKKAVLTN LVVFLLTLFW GCLGFTVFYE QLPSSLEWIL
SICSPFAFTA GMTQIIKLDY NLNGVIFPDP SGDSYTMIAT FSILLLDGFI YLLLALYFDK
ILPYGGERRY SPLFFLNSSS CFQHQGTDNK VIEKEIDVEH PSDDYFEPVA PEFQGKEAIR
IRNVKKEYKG KSGKVEALKG LLFDIYEGQI TAILGHSGAG KSSLLNILNG LSVPTEGSVT
IYNKNLSEMQ DLEEIRKITG VCPQFNVQFD ILTVKENLSL FAKIKGIHPQ EVEQEVQRIL
LELDMQNIQD NLAKHLSEGQ KRKLTFGIAI LGDPQILLLD EPTTGLDPFS RDQVWSLLRE
HRADHVILFS TQSMDEADIL ADRKVIMSNG RLKCAGSSIF LKRRWGLGYH LSLHRNEICN
PEQITSFITH HIPDAKLKTK NKEKLVYTLP LERTNIFPDL FSNLDKCSDQ GVTGYDISMS
TLNEIFMKLE GQSTIEQDFK QVEMIRDSES LNEMELAHPS FSEMQTAVSD MHLWRMQVFA
MARLRFLKLK RQTKVLLTLL LVFGIAMFPL IVENIMYAML NEKIDWEFKT ELYFLSPGQL
PQEPRTSLLI INNTESNIED FIKSLKHQNI LLEVDDFENR NGTDGLSYNG AIIVSGKQKD
YRFSVVCNTK RLHCFPILMN IISNGLLRML NHTQHIRIES SPFPLSHIGL WTGLPDGSFF
LFLVLCSISP YFTMGSISDY KKNAKSQLWI SSLYTSAYWC GQALVDVSFF ILILLAMYLI
FYIENMQYLL ITSQIVFALV IVTPGYAASL VFLIYMISFI FRKRRKNSAL WSFYFFFASI
IMFVTALISN FDLSILITTM VLVPSYTLLG FKTFLEMRDQ QHYRESPEAN FKLSATDFLV
CFIPYFQTLL FIFVLRCMEL KYGKKRMRKD PVFRISPQSR DAKPNPEEPI DEDEDVQAER
IRTATALTTS ILDEKPVIIA SCLHKEYAGQ KKSCFSKRKK KIAARNISFC VQEGEILGLL
GPNGAGKSSS IRMISGITKP TAGEVELKGC SSVLGHLGYC PQENVLWPML TAREHLEVYA
AVKGLRKVDA RLAITRLVSA FKLHEQLNVP VQKLTTGTMR KLCFVLSLLG NSPVLLLDEP
STGIDPTGQQ QMWQAIQAVV KNTERGVLLT THNLAEAEAL CDRVAIMVSG RLRCIGSIQH
LKNKLGKDYI LELKVKEPSQ VTLVHTEILK LFPQAAGQER YSSLLTYKLP VADVYPLSQA
FHKLEAVKHN FNLEEYSLSQ CTLEKVFLEL SKEQEVGNFD EEVDTTMRWK LLPHSDEP
//
