ID   A0A2K6ANW4_MACNE        Unreviewed;       526 AA.
AC   A0A2K6ANW4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Zinc finger CCCH-type containing 12D {ECO:0000313|Ensembl:ENSMNEP00000000834.1};
GN   Name=ZC3H12D {ECO:0000313|Ensembl:ENSMNEP00000000834.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000000834.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000000834.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the ZC3H12 family.
CC       {ECO:0000256|ARBA:ARBA00010922}.
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DR   RefSeq; XP_011751860.1; XM_011753558.1.
DR   RefSeq; XP_011751861.1; XM_011753559.1.
DR   RefSeq; XP_011751862.1; XM_011753560.1.
DR   RefSeq; XP_011751863.1; XM_011753561.1.
DR   STRING; 9545.ENSMNEP00000000834; -.
DR   Ensembl; ENSMNET00000004370.1; ENSMNEP00000000834.1; ENSMNEG00000004043.1.
DR   Ensembl; ENSMNET00000004379.1; ENSMNEP00000000838.1; ENSMNEG00000004043.1.
DR   GeneID; 105489003; -.
DR   KEGG; mni:105489003; -.
DR   CTD; 340152; -.
DR   GeneTree; ENSGT00940000161388; -.
DR   OrthoDB; 180910at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000004043; Expressed in lymph node and 5 other cell types or tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000932; C:P-body; IEA:Ensembl.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd18729; PIN_Zc3h12-like; 1.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   InterPro; IPR040546; Rege-1_UBA-like.
DR   InterPro; IPR021869; RNase_Zc3h12_NYN.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR   PANTHER; PTHR12876:SF11; RIBONUCLEASE ZC3H12D-RELATED; 1.
DR   Pfam; PF11977; RNase_Zc3h12a; 1.
DR   Pfam; PF18039; UBA_6; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}.
FT   DOMAIN          248..279
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50103"
FT   ZN_FING         248..279
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT   REGION          297..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..412
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..442
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  57634 MW;  34138AE4842906C7 CRC64;
     MEHPSKMEFF QKLGYDREDV LRVLGKLGEG ALVNDVLQEL IRTGSRPGAL EYPAAPRLVP
     RGSCGALDSA QRGPGTALEE DFGALASSLR PIVIDGSNVA MSHGNKETFS CRGIKLAVDW
     FRDRGHTYIK VFVPSWRKDP PRADTPIKEQ HVLAELERQA VLVYTPSRKV HGKRLVCYDD
     RYIVKVAYEQ DGVIVSNDNY RDLQSENPEW KWFIEQRLLM FSFVNDRFMP PDDPLGRHGP
     SLSNFLSRKP KPPEPSWQHC PYGKKCTYGI KCKFYHPERP HHAQLAVADE LRAKTGARPG
     AGAEEQLPPR APGGLAGARA APREPVAHSL PLARGSPDLV ALQGSFSRLA FSDDPGPLGP
     PPPGHACGLT PRLGGPDWVS EGCQVPGPLS LPSPESQFSP GDLPPPPGLQ LQPRGEQRPR
     DLHGDLLSSR RLPDDPWARL PRSDRFPGRS AWAEPAWGDG ATGGLSGYAA ENEGEARARA
     RIALYSVFPR DQVDRVMAAF PALSDLARLI LLVQRSQSAG APLGKP
//